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Production of Neutralizing Antibody
Techniques employing monoclonal antibodies (mAbs) are widely used in the initial development phase of biologics. The usefulness of mAbs in basic RA...
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Production of Secreted Antibody in Baculovirus Expression Vector System
Monoclonal antibodies have widespread applications in disease treatment and antigen detection. They are traditionally produced using mammalian cell...
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B Cells and Antibody Production in Cancer
B cells and their products play a key role in the development and progression of cancers, with pro- and antitumoral functions in the tumor...
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One-dose intradermal rabies booster enhances rabies antibody production and avidity maturation
The incidence of rabies in Thailand reached its peak in 2018 with 18 human deaths. Preexposure prophylaxis (PrEP) vaccination is thus recommended for...
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An Overview of Mouse Monoclonal Antibody Production
Antibodies are an important tool in the field of diagnostics and therapeutics owing to their affinity to bind with specific antigen. These can be of...
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IL-4-secreting CD40L+ MAIT cells support antibody production in the peripheral blood of Heonch–Schönlein purpura patients
ObjectiveHere, we explored the phenotype and function of MAIT cells in the peripheral blood of patients with HSP.
MethodsBlood samples from HSP...
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Production of an interleukin-10 blocking antibody by genetically engineered macrophages increases cancer cell death in human gastrointestinal tumor slice cultures
Although it can promote effector T-cell function, the summative effect of interleukin-10 (IL-10) in the tumor microenvironment (TME) appears to be...
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Antigen–Antibody Reactions
The interactions between antigens and antibodies are known as antigen–antibody reactions. The reactions are highly specific, and an antigen reacts...
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Production of Anti-sperm Antibody (ASA) in Women
The factors that affect production of anti-sperm antibodies (ASAs) in some women are not fully understood. Moreover, the reasons why majority of...
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Comparison of different transient gene expression systems for the production of a new humanized anti-HER2 monoclonal antibody (Hersintuzumab)
BackgroundProducing therapeutic proteins can be done quickly and on a large scale through Transient Gene Expression (TGE). Chinese hamster ovary...
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Antibody production and characterization of the nucleoprotein of sever fever with thrombocytopenia syndrome virus (SFTSV) for effective diagnosis of SFTSV
BackgroundSevere fever with thrombocytopenia syndrome (SFTS) is an infectious disease caused by the Dabie bandavirus , [or SFTS virus (SFTSV)] that...
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PI3Kγ in B cells promotes antibody responses and generation of antibody-secreting cells
The differentiation of naive and memory B cells into antibody-secreting cells (ASCs) is a key feature of adaptive immunity. The requirement for...
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Antibody Glycosylation
This book summarizes recent advances in antibody glycosylation research. Covering major topics relevant for immunoglobulin glycosylation - analytical...
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Antibody-Based Biotherapeutics in Inflammatory Diseases
Inflammatory diseases encompass a broad and diverse spectrum of serious chronic disorders, many of which have significant need for safe and effective...
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Circulating extracellular vesicle microRNAs associated with adverse reactions, proinflammatory cytokine, and antibody production after COVID-19 vaccination
mRNA-based vaccines have been used globally to eradicate the coronavirus-disease 2019 (COVID-19) pandemic. Vaccine efficacy and adverse reactions...
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Exercise 24: Monoclonal Antibody Production
Monoclonal antibodies recognize and react with a single epitope on an antigen. Monoclonal antibodies are produced by a single B cell lineage i.e. a...
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Comparison of the Euroimmun Borrelia ‘antibody index’ with Virotech immunoblot-based detection of intrathecal Borrelia antibody production for the diagnosis of Lyme neuroborreliosis
For diagnosis of neuroborreliosis, calculation of the antibody index, based on Euroimmun Anti-Borrelia plus VlsE ELISA was compared to Virotech...
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Production of Anti-sperm Antibody (ASA) in Men
The blood-testis barrier (BTB) creates favorable conditions for the spermatogenesis and sperm survival in the testicular fluid. It prevents the...
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Romidepsin (FK228) improves the survival of allogeneic skin grafts through downregulating the production of donor-specific antibody via suppressing the IRE1α-XBP1 pathway
Antibody-mediated rejection (AMR) is one of the major causes of graft loss after transplantation. Recently, the regulation of B cell differentiation...