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Epigenetic age acceleration is associated with blood lipid levels in a multi-ancestry sample of older U.S. adults
BackgroundDyslipidemia, which is characterized by an unfavorable lipid profile, is a key risk factor for cardiovascular disease (CVD). Understanding...
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Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalization
BackgroundAging has been reported as a major risk factor for severe symptoms and higher mortality rates in COVID-19 patients. Molecular hallmarks...
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How to activate the glutes best? Peak muscle activity of acceleration-specific pre-activation and traditional strength training exercises
PurposeIsometric training and pre-activation are proven to enhance acceleration performance. However, traditional strength training exercises do not...
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Effects of iron homeostasis on epigenetic age acceleration: a two-sample Mendelian randomization study
BackgroundEpigenetic clocks constructed from DNA methylation patterns have emerged as excellent predictors of aging and aging-related health...
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Choosing Optimal Cutoff Frequencies for Filtering Linear Acceleration and Angular Velocity Signals Associated with Head Impacts Measured by Instrumented Mouthguards
Head impact sensors worn in the mouth are popular because they couple directly to the teeth and provide six-degree-of-freedom head measurements....
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Effects of epigenetic age acceleration on kidney function: a Mendelian randomization study
BackgroundPrevious studies have reported cross-sectional associations between measures of epigenetic age acceleration (EAA) and kidney function...
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Characterizing Head Acceleration Events in Law Enforcement Cadets During Subject Control Technique Training
Law enforcement cadets (LECs) complete weeks of subject control technique training. Similar sport-related combat training has been shown to expose...
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Development of a Head Acceleration Event Classification Algorithm for Female Rugby Union
Instrumented mouthguards have been used to detect head accelerations and record kinematic data in numerous sports. Each recording requires validation...
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Kinematics and Activation of Hamstring Muscles During the Initial Acceleration Phase of Sprinting in Soccer Players: A Biomechanical Investigation
PurposeSprinting is the most common activity associated with hamstring strain injuries in soccer. However, the potential mechanisms for hamstring...
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Characterizing Exposure to Head Acceleration Events in Youth Football Using an Instrumented Mouthpiece
Understanding characteristics of head acceleration events (HAEs) in youth football is vital in develo** strategies to improve athlete safety. This...
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Healthy lifestyle, DNA methylation age acceleration, and incident risk of coronary heart disease
BackgroundDNA methylation clocks emerged as a tool to determine biological aging and have been related to mortality and age-related diseases. Little...
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Epigenetic age acceleration and risk of aortic valve stenosis: a bidirectional Mendelian randomization study
BackgroundAortic valve stenosis (AVS) is the most prevalent cardiac valve lesion in developed countries, and pathogenesis is closely related to...
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American Football On-Field Head Impact Kinematics: Influence of Acceleration Signal Characteristics on Peak Maximal Principal Strain
Recorded head kinematics from head-impact measurement devices (HIMd) are pivotal for evaluating brain stress and strain through head finite element...
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Approaching object acceleration differentially affects the predictions of neuronal collision avoidance models
The processing of visual information for collision avoidance has been investigated at the biophysical level in several model systems. In...
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Consensus Head Acceleration Measurement Practices (CHAMP): Origins, Methods, Transparency and Disclosure
The use of head kinematic measurement devices has recently proliferated owing to technology advances that make such measurement more feasible. In...
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Head Impacts in the Top 1% by Peak Linear Acceleration and/or Work Cause Immediate Concussion Signs and ‘Check Engine’ Responses in Military Service Members and Civilian Athletes
PurposeHistorically, head impact monitoring sensors have suffered from single impact measurement errors, leading to their data described by clinical...
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Head Impact Sensor Triggering Bias Introduced by Linear Acceleration Thresholding
Contact sports players frequently sustain head impacts, most of which are mild impacts exhibiting 10–30 g peak head center-of-gravity (CG) linear...
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Gestational age acceleration is associated with epigenetic biomarkers of prenatal physiologic stress exposure
BackgroundPhysiological maternal stress response, such as imbalance in the glucocorticoid pathway and immune system seems to be mediated by DNA...
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Defining Velocity and Acceleration Ranges for Time–Motion Analysis from a 7-Sided Game in U11 Soccer Players Using Global Positioning System Devices: A Case Study
The aims of this study were (1) to define speed and acceleration thresholds from youth match activity of soccer players and (2) to analyze the...
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Epigenetic age acceleration and cardiovascular outcomes in school-age children: The Generation R Study
BackgroundHypertension and atherosclerosis may partly originate in early life. Altered epigenetic aging may be a mechanism underlying associations of...