Search
Search Results
-
Unraveling psilocybin’s therapeutic potential: behavioral and neuroplasticity insights in Wistar-Kyoto and Wistar male rat models of treatment-resistant depression
RationaleOur study aimed to unravel the unknown mechanisms behind the exceptional efficacy of Psilocybin (PSI) in treating treatment-resistant...
-
Imiquimod-induced pruritus in female wild-type and knockin Wistar rats: underscoring behavioral scratching in a rat model for antipruritic treatments
ObjectivesAnimal models of skin disease are used to evaluate therapeutics to alleviate disease. One common clinical dermatological complaint is...
-
Establishment of a 6-OHDA Induced Unilaterally Lesioned Male Wistar Rat Model of Parkinson’s Disease
Robust preclinical models of Parkinson’s disease (PD) are valuable tools for understanding the biology and treatment of this complex disease....
-
The Search for Diagnostic Criteria to Divide the Wistar Rat Population into Phenotypes during Modeling of Post-Traumatic Stress Disorder
The levels of circulating hormones (corticosterone, testosterone, and leptin) and interleukins were studied in sexually mature male Wistar rats...
-
Thiacloprid impairs reproductive functions of male Wistar rats
Global male infertility correlated to the rise of endocrine-disrupting chemicals, including insecticides, has grown into a pressing problem....
-
Sodium acetate abates lead-induced sexual dysfunction by upregulating testosterone-dependent eNOS/NO/cGMP signaling and activating Nrf2/HO-1 in male Wistar rat
Oxidative stress has been linked with lead toxicity, including lead-induced sexual dysfunction. On the contrary, sodium acetate has been proven to...
-
Evaluating Motor Dysfunction and Oxidative Stress Induced by Trichloroethylene in Wistar Rats
Trichloroethylene, a chlorinated solvent widely used as a degreasing agent, is a common environmental contaminant. Emerging evidence suggests that...
-
Impact of infrasound exposure and streptozotocin-induced glucose intolerance on bone composition in Wistar rats
The elemental composition of chemical elements can vary between healthy and diseased tissues, providing essential insights into metabolic processes...
-
Evaluation of the therapeutic potential of cerebrolysin and/or lithium in the male Wistar rat model of Parkinson’s disease induced by reserpine
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease worldwide and represents a challenge for clinicians. The present...
-
Melatonin counteracts aluminum-induced affective and cognitive disorders and oxidative damage in male wistar rats
Aluminum (Al) is a potentially toxic element causing many neuropathological and behavioral alterations such as affective and cognitive disorders....
-
Polymeric micelle gel with luliconazole: in vivo efficacy against cutaneous candidiasis in Wistar rats
The objective of this research was focused on the design and development of luliconazole-loaded polymeric micelle hydrogel (LUL-PM-CHG) using quality...
-
Effect of Short PSG Peptides on Inflammatory Markers in Allogeneic Bone Marrow Cell Transplantation in Wistar Rats
Short linear peptide fragments of placental trophoblastic β1-glycoprotein (PSG) (YECE, YQCE, YVCS, and YACS) were studied in the context of their...
-
Comparative Molecular and Biological Characteristic of the Systemic Inflammatory Response in Adult and Old Male Wistar Rats with Different Resistance to Hypoxia
Morphological, molecular, and biological features of the systemic inflammatory response induced by LPS administration were assessed in adult and old...
-
Habenula as a Possible Target for Treatment-Resistant Depression Phenotype in Wistar Kyoto Rats
The mechanisms of treatment-resistant depression (TRD) are not clear and are difficult to study. An animal model resembling human TRD is the Wistar...
-
Differential Effects of Neonatal Ventral Hippocampus Lesion on Behavior and Corticolimbic Plasticity in Wistar–Kyoto and Spontaneously Hypertensive Rats
Dysfunction of the corticolimbic system, particularly at the dendritic spine level, is a recognized core mechanism in neurodevelopmental disorders...
-
Hypothyroidism Modeling in Wistar Rats: Comparison of Two Surgical Methods
In this study we present 2 surgical models of hypothyroidism in male Wistar rats ( n =80) based on total thyroidectomy. Animals weighing 180-200 g were...
-
Parameters of Heart Rate Variability in Male Wistar Rats under Conditions of Different Motor Activity
We studied heart rate variability indexes in freely moving male Wistar rats at rest and under conditions of increased motor activity (treadmill...
-
Idelalisib, a Selective Phosphatidylinositol-3-Kinase Inhibitor, Suppresses Pentylenetetrazole-Induced Convulsions in Wistar Rats
AbstractEpilepsy results from abnormal brain function and is one of the most common neurological diseases in the world. The...
-
Berberine attenuates brain aging via stabilizing redox homeostasis and inflammation in an accelerated senescence model of Wistar rats
Aging is a multifacetedand progressive physiological change of the organism categorized by the accumulation of deteriorating processes, which...
-
Effects of lipopolysaccharide administration at different postnatal periods on behavioral and biochemical assessments in Wistar rats
Rodent model systems using lipopolysaccharide (LPS) administration have been developed to examine the effect of postnatal inflammation on...
