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Whole-brain Optical Imaging: A Powerful Tool for Precise Brain Map** at the Mesoscopic Level
The mammalian brain is a highly complex network that consists of millions to billions of densely-interconnected neurons. Precise dissection of neural...
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Propensity score-matched analysis comparing hippocampus-avoidance whole-brain radiotherapy plus simultaneous integrated boost with hippocampus‑avoidance whole-brain radiotherapy alone for multiple brain metastases-a retrospective study in multiple institutions
BackgroundThe optimal treatment for multiple brain metastases has been recently controversially discussed.This study was aimed to explore the...
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In Vivo Whole-Cell Recording from the Mouse Brain
Measuring the membrane potential dynamics of neurons offers a comprehensive understanding of the molecular and cellular mechanisms that form their...
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Whole-brain gray matter maturation trajectories associated with autistic traits from adolescence to early adulthood
A growing number of evidence supports a continued distribution of autistic traits in the general population. However, brain maturation trajectories...
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Delineation of recurrent glioblastoma by whole brain spectroscopic magnetic resonance imaging
BackgroundGlioblastoma (GBM) cellularity correlates with whole brain spectroscopic MRI (sMRI) generated relative choline to N -Acetyl-Aspartate ratio...
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Adding simultaneous integrated boost to whole brain radiation therapy improved intracranial tumour control and minimize radiation-induced brain injury risk for the treatment of brain metastases
BackgroundBrain metastases (BMs) are the most frequent intracranial tumours associated with poor clinical outcomes. Radiotherapy is essential in the...
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Whole-brain connections of glutamatergic neurons in the mouse lateral habenula in both sexes
BackgroundThe lateral habenula (LHb) is an epithalamus nucleus that is evolutionarily conserved and involved in various physiological functions, such...
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Effects of whole-brain radiation therapy on the blood–brain barrier in immunocompetent and immunocompromised mouse models
BackgroundApproximately 20% of all cancer patients will develop brain metastases in their lifespan. The standard of care for patients with multiple...
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3D Visualization of Whole Brain Vessels and Quantification of Vascular Pathology in a Chronic Hypoperfusion Model Causing White Matter Damage
Chronic cerebral hypoperfusion is an important pathological factor in many neurodegenerative diseases, such as cerebral small vessel disease (CSVD)....
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Multimodal tract-based MRI metrics outperform whole brain markers in determining cognitive impact of small vessel disease-related brain injury
In cerebral small vessel disease (cSVD), whole brain MRI markers of cSVD-related brain injury explain limited variance to support individualized...
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Patient reported outcomes following whole brain radiotherapy in patients with brain metastases in NSIA-LUTH Cancer Center
BackgroundBrain metastases (BM) are a common complication in advanced cancer patients, and extremely challenging to treat. Consequently, whole brain...
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Retrospective study of hypofractionated stereotactic radiotherapy combined with whole brain radiotherapy for patients with brain metastases
Background and purposeTo evaluate the clinical outcomes of hypofractionated stereotactic radiotherapy (HFSRT) combined with whole brain radiotherapy...
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Glasgow prognostic score for assessing the efficacy of whole-brain radiation therapy in cases of recursive partitioning analysis class 2 and class 3 multiple brain metastases: a retrospective study
PurposeWhole-brain radiotherapy (WBRT) may not be beneficial for patients with brain metastases (BMs). The Glasgow Prognostic Score (GPS) is a...
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May we routinely spare hippocampal region in primary central nervous system lymphoma during whole brain radiotherapy?
PurposeOne of the main limiting factors of whole-brain radiation therapy (WBRT) for primary central nervous system lymphoma (PCNSL) is the impairment...
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Interaction between childhood trauma experience and TPH2 rs7305115 gene polymorphism in brain gray matter volume
BackgroundChildhood trauma is one of the most extensively studied and well-supported environmental risk factors for the development of mental health...
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Application of piecewise VMAT technique to whole-brain radiotherapy with simultaneous integrated boost for multiple metastases
PurposeThis study implemented a piecewise volumetric modulated arc therapy (P-VMAT) for realizing whole-brain radiation therapy (WBRT) with...
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Cortical pain induced by optogenetic cortical spreading depression: from whole brain activity map**
BackgroundCortical spreading depression (CSD) is an electrophysiological event underlying migraine aura. Traditional CSD models are invasive and...
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Association between the Pittsburgh sleep quality index and white matter integrity in healthy adults: a whole-brain magnetic resonance imaging study
To disclose possible associations between poorer sleep quality and structural brain alterations in a non-psychiatric healthy population, this study...
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Whole-Brain Modelling: Past, Present, and Future
Whole-Brain Modelling is a scientific field with a short history and a long past. Its various disciplinary roots and conceptual ingredients extend...
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Brain (Yakovlevian) torque direction is associated with volume asymmetry of the intracranial transverse sinuses: evidence from situs inversus totalis
Previous research reported reversal of the prototypical brain torque in individuals with mirrored visceral topology (situs inversus totalis, SIT)....
