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AD Blank Spot Model for Evaluation of Alzheimer’s Disease
The discovery of biomarkers that confer high confidence of Alzheimer’s disease (AD) diagnosis and disease management would be a valuable tool to...
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AD Blank Spot Model for Evaluation of Alzheimer’s Disease
The discovery of biomarkers that confer high confidence of Alzheimer’s disease (AD) diagnosis and disease management would be a valuable tool to...
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Shrimp classification for white spot syndrome detection through enhanced gated recurrent unit-based wild geese migration optimization algorithm
The major dangerous viral infection for cultivated shrimps is WSSV. The virus is extremely dangerous, spreads swiftly, and may result in up to 100%...
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3D Visualization of Whole Brain Vessels and Quantification of Vascular Pathology in a Chronic Hypoperfusion Model Causing White Matter Damage
Chronic cerebral hypoperfusion is an important pathological factor in many neurodegenerative diseases, such as cerebral small vessel disease (CSVD)....
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Finding the sweet spot: a qualitative study exploring patients’ acceptability of chatbots in genetic service delivery
Chatbots, web-based artificial intelligence tools that simulate human conversation, are increasingly in use to support many areas of genomic...
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Burden and predictors of diabetic kidney disease in an adult Ugandan population with new-onset diabetes
BackgroundDespite the growing evidence of diabetic kidney disease (DKD) in adult patients with long-standing diabetes in sub-Saharan Africa, data on...
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Spatiotemporal characterization of glial cell activation in an Alzheimer’s disease model by spatially resolved transcriptomics
The molecular changes that occur with the progression of Alzheimer’s disease (AD) are well known, but an understanding of the spatiotemporal...
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Quantitative imagery analysis of spot patterns for the three-haplogroup classification of Triatoma dimidiata (Latreille, 1811) (Hemiptera: Reduviidae), an important vector of Chagas disease
BackgroundSpots and coloring patterns evaluated quantitatively can be used to discriminate and identify possible cryptic species. Species included in...
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Apolipoprotein E ɛ2 Is Associated with the White Matter Hyperintensity Multispot Pattern in Spontaneous Intracerebral Hemorrhage
The white matter hyperintensity (WMH) multispot pattern, as multiple punctate subcortical foci, could differentiate cerebral amyloid angiopathy (CAA)...
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Molecular, histopathologic and electron microscopic analysis of white spot syndrome virus in wild shrimp (Fenneropenaeus indicus) in the coastal waters of Iran
So far, there have been no studies on the distribution of viral white spot syndrome in wild Indian white shrimp ( Fenneropenaeus indicus ) brooders at...
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Mitochondrial genetic variation and risk of chronic kidney disease and acute kidney injury in UK Biobank participants
Experimental models suggest an important role for mitochondrial dysfunction in the pathogenesis of chronic kidney disease (CKD) and acute kidney...
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IgG4 Disease-Related Ataxia
We describe a male patient presenting with cerebellar ataxia and behavioural frontotemporal dementia in whom imaging showed cerebellar atrophy. He...
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Expanding the Australian Newborn Blood Spot Screening Program using genomic sequencing: do we want it and are we ready?
Since the introduction of genome sequencing in medicine, the factors involved in deciding how to integrate this technology into population screening...
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Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer’s disease
Human middle temporal gyrus (MTG) is a vulnerable brain region in early Alzheimer’s disease (AD), but little is known about the molecular mechanisms...
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Preclinical safety assessment of the suction-assisted intradermal injection of the SARS-CoV-2 DNA vaccine candidate pGO-1002 in white rabbit
pGO-1002, a non-viral DNA vaccine that expresses both spike and ORF3a antigens of SARS-CoV-2, is undergoing phase 1 and phase 2a clinical trials in...
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In vivo probabilistic atlas of white matter tracts of the human subthalamic area combining track density imaging and optimized diffusion tractography
The human subthalamic area is a region of high anatomical complexity, tightly packed with tiny fiber bundles. Some of them, including the...
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Characterization of a reassortant H11N9 subtype avian influenza virus isolated from spot-billed duck in China
H11N9 viruses in wild birds might have provided the NA gene of human H7N9 virus in early 2013 in China, which evolved with highly pathogenic strains...
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Machine Learning in Plant Disease Research
Biotic agents including virus, viroids, fungi, bacteria, mollicutes, protozoa, and nematodes and adverse environmental conditions can affect the...
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Late-onset fabry disease due to the p.Phe113Leu variant: the first italian cluster of five families
BackgroundThe GLA c.337T > C (p.Phe113Leu) is a known pathogenic variant associated to late-onset Fabry disease phenotype with predominant cardiac...
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Proteomic features of gray matter layers and superficial white matter of the rhesus monkey neocortex: comparison of prefrontal area 46 and occipital area 17
In this novel large-scale multiplexed immunofluorescence study we comprehensively characterized and compared layer-specific proteomic features within...
