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Colorectal cancer screening: results from the World Trade Center Health Registry cohort
PurposeLittle is known about colorectal cancer screening in 9/11 World Trade Center (WTC)-exposed populations. We utilized survey data from the WTC...
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World Trade Center Site Exposure Duration Is Associated with Hippocampal and Cerebral White Matter Neuroinflammation
Responders to the World Trade Center (WTC) attacks on 9/11/2001 inhaled toxic dust and experienced severe trauma for a prolonged period. Studies...
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Myeloma precursor disease (MGUS) among rescue and recovery workers exposed to the World Trade Center disaster
An elevated risk of myeloma precursor disease, monoclonal gammopathy of undetermined significance (MGUS), was identified among Fire Department of the...
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High burden of clonal hematopoiesis in first responders exposed to the World Trade Center disaster
The terrorist attacks on the World Trade Center (WTC) created an unprecedented environmental exposure to aerosolized dust, gases and potential...
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Subjective cognitive concerns, APOE ε4, PTSD symptoms, and risk for dementia among older veterans
BackgroundPosttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) are associated with self-reported problems with cognition as well as...
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Functional dissection of human cardiac enhancers and noncoding de novo variants in congenital heart disease
Rare coding mutations cause ∼45% of congenital heart disease (CHD). Noncoding mutations that perturb cis -regulatory elements (CREs) likely contribute...
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Myoscaffolds reveal laminin scarring is detrimental for stem cell function while sarcospan induces compensatory fibrosis
We developed an on-slide decellularization approach to generate acellular extracellular matrix (ECM) myoscaffolds that can be repopulated with...
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The development of a Biobank of cancer tissue samples from World Trade Center responders
BackgroundWorld Trade Center (WTC) responders were exposed to mixture of dust, smoke, chemicals and carcinogens. Studies of cancer incidence in this...
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DNA-Based Human Identification in Mass-Disaster Cases
Mass disasters are sudden and unpredictable incidents causing catastrophic damage, serious injuries, and/or deaths. Disasters may be natural or...
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Segmental Variations in the Peel Characteristics of the Porcine Thoracic Aorta
Aortic dissection occurs predominantly in the thoracic aorta and the mechanisms for the initiation and propagation of the tear in aortic dissection...
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Endurance Exercise Training in Young Adults with Barth Syndrome: A Pilot Study
Background: Barth syndrome (BTHS) is a rare X-linked disorder that is characterized by mitochondrial abnormalities, cardio-skeletal myopathy,...
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Evaluation of non-response bias in a cohort study of World Trade Center terrorist attack survivors
BackgroundFew longitudinal studies of disaster cohorts have assessed both non-response bias in prevalence estimates of health outcomes and in the...
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Incomplete lung recovery following sub-acute inhalation of combustion-derived ultrafine particles in mice
BackgroundParticulate matter (PM) is one of the six criteria pollutant classes for which National Ambient Air Quality Standards have been set by the...
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Intergenerational Effects of PTSD on Offspring Glucocorticoid Receptor Methylation
Posttraumatic stress disorder is precipitated by the experience of extreme stress in a subset of vulnerable individuals. Data now suggest that PTSD...
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BDNF in Lower Brain Parts Modifies Auditory Fiber Activity to Gain Fidelity but Increases the Risk for Generation of Central Noise After Injury
For all sensory organs, the establishment of spatial and temporal cortical resolution is assumed to be initiated by the first sensory experience and...
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