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Design and Development of Gastro-retentive Drug Delivery System for Trazodone Hydrochloride: a Promising Alternative to Innovator’s Controlled-Release Tablet
Trazodone hydrochloride (TZN) is a serotonin reuptake inhibitor that treats a major depressive disorder. It exhibits a short plasma half-life of 4.1...
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Feasibility and outcomes of supplemental gait training by robotic and conventional means in acute stroke rehabilitation
IntroductionPracticality of implementation and dosing of supplemental gait training in an acute stroke inpatient rehabilitation setting are not well...
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Incidence and pattern of childhood cancer in Addis Ababa, Ethiopia (2012–2017)
BackgroundCancer is becoming a major public health problem globally and a leading cause of death in children in developed countries. However, little...
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Basal ganglia engagement during REM sleep movements in Parkinson’s disease
To elucidate the role of the basal ganglia during REM sleep movements in Parkinson’s disease (PD) we recorded pallidal neural activity from four PD...
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The Effects of Micro-vessel Curvature Induced Elongational Flows on Platelet Adhesion
The emerging profile of blood flow and the cross-sectional distribution of blood cells have far reaching biological consequences in various diseases...
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Development and Evaluation of Controlled and Simultaneous Release of Compound Danshen Based on a Novel Colon-Specific Osmotic Pump Capsule
In the study, we developed a novel oral dosage form of Compound Danshen to resolve the problems of low bioavailability, disequilibrium in drug...
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A novel Posaconazole oral formulation using spray dried solid dispersion technology: in-vitro and in-vivo study
SD (solid dispersion) technology is one of the well-recognized solubility enhancement methods; but the use of versatile carriers in ASD (amorphous...
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Self-regulated Anti-Overdose Crush and Extraction-Resistant Drug Delivery System to Combat Opioid Overdose Crisis
Pharmaceutical opioid dosage forms are commonly misused via an oral route in non-manipulated form, i.e., overdose in intact form, or manipulated...
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A Chewing Study of Abuse-Deterrent Tablets Containing Polyethylene Oxide Using a Robotic Simulator
Abuse-deterrent formulations (ADFs) refer to formulation technologies aiming to deter the abuse of prescription drugs by making the dosage forms...
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Molecular response to induction chemotherapy and its correlation with treatment outcome in head and neck cancer patients by means of NMR-based metabolomics
BackgroundThe aim of this prospective study is to identify the biomarkers associated with the effects of induction chemotherapy (iCHT) in terms of...
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Quantitative Meta-analyses of Cognitive Abilities in Children With Pediatric-onset Multiple Sclerosis
Pediatric-onset multiple sclerosis (POMS), is the manifestation of multiple sclerosis in individuals before 18 years of age. About a third of...
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Autism spectrum disorder diagnosis based on deep unrolling-based spatial constraint representation
AbstractAccurate diagnosis of autism spectrum disorder (ASD) is crucial for effective treatment and prognosis. Functional brain networks (FBNs)...
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Three-Dimensional (3D)–Printed Zero-Order Released Platform: a Novel Method of Personalized Dosage Form Design and Manufacturing
In 2017, there are 451 million people with diabetes worldwide. These figures were expected to increase to 693 million by 2045. The research and...
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Human rs75776403 polymorphism links differential phenotypic and clinical outcomes to a CLEC18A p.T151M-driven multiomics
BackgroundHuman traits, diseases susceptibility, and clinical outcomes vary hugely among individuals. Despite a fundamental understanding of genetic...
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In vitro susceptibility of Neisseria gonorrhoeae to netilmicin and etimicin in comparison to gentamicin and other aminoglycosides
PurposeSingle doses of gentamicin have demonstrated clinical efficacy in the treatment of urogenital gonorrhea, but lower cure rates for...
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Qualitative Interviews to Add Patient Perspectives in Colorectal Cancer Screening: Improvements in a Learning Health System
Health systems are interested in increasing colorectal cancer (CRC) screening rates as CRC is a leading cause of preventable cancer death. Learning...
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Designing, Preparation, and Evaluation of Orodispersible Chitosan Anionic Salt Tablets
IntroductionOral dispersible tablets (ODTs) are promising pharmaceutical dosage forms and, theoretically, could be used for many active...
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Capsule and Tablet Dosage Forms
This chapter provides an overview of the design, manufacturing, and formulation of capsule and tablet-based drug products. Manufacturing methods for...
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Development of a long-acting tablet with ticagrelor high-loaded nanostructured lipid carriers
Ticagrelor (TCG), an antiplatelet agent, has low solubility and permeability; thus, there are many trials to apply the pharmaceutical technology for...
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Dynamic Coronary Blood Flow Velocity and Wall Shear Stress Estimation Using Ultrasound in an Ex Vivo Porcine Heart
PurposeWall shear stress (WSS) is a critically important physical factor contributing to atherosclerosis. Map** the spatial distribution of local,...
