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Identification of genetic mechanisms underlying lipid metabolism-mediated tumor immunity in head and neck squamous cell carcinoma
ObjectiveTo identify the genetic mechanisms underlying lipid metabolism-mediated tumor immunity in head and neck squamous carcinoma (HNSC).
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A meta-validated immune infiltration-related gene model predicts prognosis and immunotherapy sensitivity in HNSCC
BackgroundTumor microenvironment (TME) is of great importance to regulate the initiation and advance of cancer. The immune infiltration patterns of...
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Identifying Novel Drug Targets for Epilepsy Through a Brain Transcriptome-Wide Association Study and Protein-Wide Association Study with Chemical-Gene-Interaction Analysis
Epilepsy is a severe neurological condition affecting 50–65 million individuals worldwide that can lead to brain damage. Nevertheless, the etiology...
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WIPF1 antagonizes the tumor suppressive effect of miR-141/200c and is associated with poor survival in patients with PDAC
BackgroundAberrant expression of Wiskott–Aldrich syndrome protein interacting protein family member 1 (WIPF1) contributes to the invasion and...
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The regulatory role of LncRNA HCG18 in various cancers
As a member of long non-coding RNAs (lncRNAs), LncRNA HLA complex group 18 (HCG18) has recently become the focus of cancer research. As outlined in...
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RNA sequencing reveals dynamic expression of spleen lncRNAs and mRNAs in Beagle dogs infected by Toxocara canis
BackgroundToxocara canis is a cosmopolitan parasite with a significant adverse impact on the health of humans and animals. The spleen is a major...
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Epithelial–Mesenchymal Transition and Cancer Stem Cells
Epithelial–mesenchymal transition (EMT), a cellular phenotypic change from epithelial to mesenchymal-like features, is related to the resistance and...
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Transgelin interacts with PARP1 in human colon cancer cells
BackgroundTransgelin, an actin-binding protein, is associated with cytoskeleton remodeling. Findings from our previous studies demonstrated that...
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Genomic approaches to identify and investigate genes associated with atrial fibrillation and heart failure susceptibility
Atrial fibrillation (AF) and heart failure (HF) contribute to about 45% of all cardiovascular disease (CVD) deaths in the USA and around the globe....
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The interplay between noncoding RNA and YAP/TAZ signaling in cancers: molecular functions and mechanisms
The Hippo signaling pathway was found coordinately modulates cell regeneration and organ size. Its dysregulation contributes to uncontrolled cell...
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Involvement of immune system and Epithelial–Mesenchymal-Transition in increased invasiveness of clustered circulatory tumor cells in breast cancer
BackgroundCirculating tumor cells (CTCs) are the critical initiators of distant metastasis formation. In which, the reciprocal interplay among...
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Unraveling the dynamic mechanisms of natural killer cells in viral infections: insights and implications
Viruses pose a constant threat to human well-being, necessitating the immune system to develop robust defenses. Natural killer (NK) cells, which play...
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Inborn Errors of Immunity in Hidradenitis Suppurativa Pathogenesis and Disease Burden
Hidradenitis suppurativa (HS), also known as Verneuil’s disease and acne inversa, is a prevalent, debilitating, and understudied inflammatory skin...
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High-plex spatial transcriptomic profiling reveals distinct immune components and the HLA class I/DNMT3A/CD8 modulatory axis in mismatch repair-deficient endometrial cancer
PurposeTumors bearing mismatch repair deficiency (MMRd) are characterized by a high load of neoantigens and are believed to trigger immunogenic...
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MicroRNA-130b Suppresses Malignant Behaviours and Inhibits the Activation of the PI3K/Akt Signaling Pathway by Targeting MET in Pancreatic Cancer
There has been interested in the microRNAs’ roles in pancreatic cancer (PC) cell biology, particularly in regulating pathways related to...
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MiR-200/183 family-mediated module biomarker for gastric cancer progression: an AI-assisted bioinformatics method with experimental functional survey
BackgroundGastric cancer (GC) is a major cancer burden throughout the world with a high mortality rate. The performance of current predictive and...
