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The Cannabinoid WIN 55,212-2 Reduces Delayed Neurologic Sequelae After Carbon Monoxide Poisoning by Promoting Microglial M2 Polarization Through ST2 Signaling
Delayed neurologic sequelae (DNS) are among the most serious complications of carbon monoxide (CO) poisoning caused partly by elevated...
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Gut Microbiota-Mediated Alterations of Hippocampal CB1R Regulating the Diurnal Variation of Cognitive Impairment Induced by Hepatic Ischemia–Reperfusion Injury in Mice
Patients suffering from hepatic ischemia–reperfusion injury (HIRI) frequently exhibit postoperative cognitive deficits. Our previous observations...
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Endocannabinoid System Attenuates Oxaliplatin-Induced Peripheral Sensory Neuropathy Through the Activation of CB1 Receptors
Oxaliplatin-induced neurotoxicity is expressed as a dose-limiting peripheral sensory neuropathy (PSN). Cannabinoid substances have been investigated...
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Modulation of the CB1 cannabinoid receptor has potential therapeutic utility in the 3-acetylpyridine cerebellar ataxia rat model
Cerebellar ataxia is a neurodegenerative disorder leading to severe motor incoordination. Recently, it has been suggested that cannabinoids play a...
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Effects of GABAA receptors in nucleus cuneiformis on the cannabinoid antinociception using the formalin test
RationaleNucleus cuneiformis (NC), a reticular nucleus of the midbrain, is a part of the descending pain modulatory system and therefore has an...
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Systematic review of the impact of cannabinoids on neurobehavioral outcomes in preclinical models of traumatic and nontraumatic spinal cord injury
Study designSystematic review.
ObjectivesTo evaluate the impact of cannabinoids on neurobehavioral outcomes in preclinical models of nontraumatic...
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Neuroprotective Action of the CB1/2 Receptor Agonist, WIN 55,212-2, against DMSO but Not Phenobarbital-Induced Neurotoxicity in Immature Rats
The develo** brain is uniquely susceptible to drug-induced increases in programmed cell death or apoptosis. Many compounds, including...
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Local activation of CB1 receptors by synthetic and endogenous cannabinoids dampens burst firing mode of reticular thalamic nucleus neurons in rats under ketamine anesthesia
The reticular thalamic nucleus (RTN) is a thin shell that covers the dorsal thalamus and controls the overall information flow from the thalamus to...
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Effects of combined 5-HT2A and cannabinoid receptor modulation on a schizophrenia-related prepulse inhibition deficit in mice
RationalePrepulse inhibition of the startle reflex (PPI) is disrupted in several psychiatric disorders including schizophrenia. Understanding PPI...
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Therapeutic Molecular Insights into the Active Engagement of Cannabinoids in the Therapy of Parkinson’s Disease: A Novel and Futuristic Approach
Parkinson’s disease is a neurodegenerative disorder which is characterised mostly by loss of dopaminergic nerve cells throughout the nigral area...
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Modulatory Activity of the Endocannabinoid System in the Development and Proliferation of Cells in the CNS
The Endocannabinoid System (ECS, also known as Endocannabinoidome) plays a key role in the function of the Central Nervous System, though the...
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Repeated Δ-9-Tetrahydrocannabinol administration dose dependently increases stablished schedule-induced drinking
RationaleSchedule-induced drinking (SID) reproduces an excessive and repetitive behavioural pattern that has led to propose this procedure as an...
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Tetrahydrocannabinols: potential cannabimimetic agents for cancer therapy
Tetrahydrocannabinols (THCs) antagonize the CB1 and CB2 cannabinoid receptors, whose signaling to the endocannabinoid system is essential for...
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Emerging Role of Cannabinoid System Modulators in Treatment of Cancer
Endocannabinoid system (ECS) and its agonist/antagonists are emerging drug target in different pathophysiological conditions, and its role as an...
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Involvement of the CB2 cannabinoid receptor in cell growth inhibition and G0/G1 cell cycle arrest via the cannabinoid agonist WIN 55,212–2 in renal cell carcinoma
BackgroundThe anti-tumor properties of cannabinoids have been investigated in many in vitro and in vivo studies. Many of these anti-tumor effects are...
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Interactions Between the Ubiquitin–Proteasome System, Nrf2, and the Cannabinoidome as Protective Strategies to Combat Neurodegeneration: Review on Experimental Evidence
Neurodegenerative disorders are chronic brain diseases that affect humans worldwide. Although many different factors are thought to be involved in...
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Cannabinoid system involves in the analgesic effect of protocatechuic acid
BackgroundProtocatechuic acid is an antioxidant which is shown to have analgesic activity in limited studies. However, the mechanisms of action...
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Cannabinoids as anticancer drugs: current status of preclinical research
Drugs that target the endocannabinoid system are of interest as pharmacological options to combat cancer and to improve the life quality of cancer...
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Interaction of endocannabinoid system and cyclooxygenase metabolites with fatty acid amide hydrolase and cyclooxygenase enzyme activities on contractile responses in rat vas deferens tissue
The endocannabinoid system and prostaglandins are important modulators in the genitourinary system. This study aimed to investigate the possible...
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Unraveling the Endocannabinoid System: Exploring Its Therapeutic Potential in Autism Spectrum Disorder
The salient features of autism spectrum disorder (ASD) encompass persistent difficulties in social communication, as well as the presence of...
