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Visceral Pain
The chapters in this book are based on the Visceral Pain conference in Adelaide, Australia, under the auspices of the International Federation for...
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Epithelial-Neuronal Communication in Visceral Pain
Visceral hypersensitivity and pain are common symptoms of irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). Pain results, at least...
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Features of the Neurophysiological Mechanisms of Visceral and Somatic Pain
Most current data on the neurophysiology of pain were obtained from studies of somatic pain syndromes. Until recently, these processes were regarded...
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Non-invasive neuromodulation: an emerging intervention for visceral pain in gastrointestinal disorders
Gastrointestinal (GI) disorders, which extend from the esophagus to the anus, are the most common diseases of the GI tract. Among these disorders,...
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Thalamic Nucleus Reuniens Glutamatergic Neurons Mediate Colorectal Visceral Pain in Mice via 5-HT2B Receptors
Irritable bowel syndrome (IBS) is a common functional bowel disorder characterized by abdominal pain and visceral hypersensitivity. Reducing visceral...
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P2X7 and P2Y1 receptors in DRG mediate electroacupuncture to inhibit peripheral sensitization in rats with IBS visceral pain
Although multiple purinergic receptors mediate the analgesic effects of acupuncture, it remains unclear whether there is mutual interaction between...
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The locus coeruleus input to the rostral ventromedial medulla mediates stress-induced colorectal visceral pain
Unlike physiological stress, which carries survival value, pathological stress is widespread in modern society and acts as a main risk factor for...
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The Biomechanics of Distal Colon and Rectum and Its Relevance to Visceral Pain
Visceral pain differs significantly from cutaneous pain in both its clinical and psychophysical manifestations. There is a prominent “mechanical”...
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Moxibustion ameliorates chronic inflammatory visceral pain via spinal circRNA-miRNA-mRNA networks: a central mechanism study
This study aimed to unveil the central mechanism of moxibustion treating chronic inflammatory visceral pain (CIVP) from the angle of...
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Epigenetic Regulation of Stress-Induced Visceral Pain
Persistent abdominal pain is the most important reason for patients with irritable bowel syndrome (IBS) to seek medical care. However, current...
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Visceral Nociception in Gastrointestinal Disease
Abdominal pain is common across organic and functional gastrointestinal disorders. For example, most patients with inflammatory bowel disease (IBD)...
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Stress-Induced Visceral Analgesia: Concept and Pathways
Decades of research in the somatic pain field have established that stress has a major influence on pain modulation affecting it in two opposite...
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Optogenetic Modulation of the Visceromotor Response to Reveal Visceral Pain Mechanisms
Visceral pain is a debilitating condition that is common yet lacks effective treatments. In the case of gastrointestinal disorders (e.g.,...
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Nalbuphine alleviates inflammation by down-regulating NF-κB in an acute inflammatory visceral pain rat model
IntroductionNalbuphine can relieve patients’ inflammation response after surgery compared to other opioid drugs. However, its molecular mechanism has...
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Inhibition of P2X7 receptors by Lu AF27139 diminishes colonic hypersensitivity and CNS prostanoid levels in a rat model of visceral pain
Visceral pain is a prominent feature of various gastrointestinal diseases. The P2X7 receptor is expressed by multiple cell types including dorsal...
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Neuron-Microglia Dynamic Duo in Chronic Abdominal Pain
Abdominal pain is one of the main symptoms of chronic gastrointestinal disorders including inflammatory bowel diseases (IBD) and irritable bowel...
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Spinal Microglia and Astrocytes: Two Key Players in Chronic Visceral Pain Pathogenesis
Chronic visceral pain (CVP) is one of the common symptoms of many diseases triggered by underlying diseases of the internal organs of the human body....
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Physiological Mechanisms Underpinning Heightened Perception of Visceral Afferent Signalling in Irritable Bowel Syndrome
Interoceptive information relating to intestinal activity and environmental changes in the gut lumen is continuously and, generally, subconsciously...
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Mechanisms of Spinal Cord Plasticity in Rodent Models of Acute and Post-Colitis Visceral Hypersensitivity
Inflammation of the colon is well-established as an initiating factor in the development of chronic visceral pain. Colitis induces sensitisation at...
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Visceral and Tegumentary Leishmaniasis
Visceral and tegumentary leishmaniasis are neglected tropical diseases caused by the protozoan parasite Leishmania. In this chapter, we discuss the...