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Dendritic-cell-targeting virus-like particles as potent mRNA vaccine carriers
Messenger RNA vaccines lack specificity for dendritic cells (DCs)—the most effective cells at antigen presentation. Here we report the design and...
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Design of hepadnavirus core protein-based chimeric virus-like particles carrying epitopes from respiratory syncytial virus
Respiratory syncytial virus (RSV) is one of the most important pathogens causing respiratory tract infection in humans, especially in infants and the...
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Analyzing atomic force microscopy images of virus-like particles by expectation-maximization
Analysis of virus-like particles (VLPs) is an essential task in optimizing their implementation as vaccine antigens for virus-initiated diseases....
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Extraction of Modified Adeno-Associated Virus-Like Particles Displaying Peptides on Their Surface
Virus-like particles (VLPs) of the adeno-associated virus (AAV) can be produced using the baculovirus expression vector system. Insertion of small...
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The In Vitro Packaging of “Overlong” RNA by Spherical Virus-Like Particles
Of the myriad viruses, very few have been shown to be capable of self-assembly in vitro from purified components into infectious virus particles. One...
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Ebola virus–like particles reprogram cellular metabolism
AbstractEbola virus can trigger a release of pro-inflammatory cytokines with subsequent vascular leakage and impairment of clotting finally leading...
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One-Step Purification Strategy for Cowpea Chlorotic Mottle Virus-Like Particles Produced by the IC-BEVS
Virus-like particles (VLP) of the cowpea chlorotic mottle virus (CCMV), a plant virus, have been shown to be safe and noncytotoxic vehicles for...
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Two-component vaccine consisting of virus-like particles displaying hepatitis C virus envelope protein 2 oligomers
Development of B-cell-based hepatitis C virus (HCV) vaccines that induce broadly neutralizing antibodies (bNAbs) is hindered by extensive sequence...
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Generation of porcine circovirus type 4 virus-like particles and their use to detect serum antibodies
Porcine circovirus type 4 (PCV4), first identified in 2019 as a newly emerging pathogen, has been found in several provinces of China, as well as in...
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Hemagglutinin virus-like particles incorporated with membrane-bound cytokine adjuvants provide protection against homologous and heterologous influenza virus challenge in aged mice
BackgroundCurrent influenza vaccines deliver satisfactory results in young people but are less effective in the elderly. Development of vaccines for...
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A mosaic influenza virus-like particles vaccine provides broad humoral and cellular immune responses against influenza A viruses
The development of a universal influenza vaccine to elicit broad immune responses is essential in reducing disease burden and pandemic impact. In...
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Platform Technologies Based on Virus-Like Particles (VLPs) for Infectious Diseases
Platform technologies provide an effective tool where peptides and protein antigens are incorporated onto virus-like particles (VLPs) to enhance...
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Recent Advancements and Challenges in Recombinant Expression for Commercial Production of Virus-Like Particles (VLPs)
Virus-like particles (VLPs) are mimics of native viruses that are generated from the self-assembly of viral structural proteins. The particles lack...
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Stability and integrity of self-assembled bovine parvovirus virus‑like particles (BPV‑VLPs) of VP2 and combination of VP1VP2 assisted by baculovirus-insect cell expression: a potential logistical platform for vaccine deployment
BackgroundBovine parvovirus (BPV) is an autonomous DNA virus with a smaller molecular size and subtle differences in its structural proteins, unlike...
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A single immunization with a modified vaccinia Ankara vectored vaccine producing Sudan virus-like particles protects from lethal infection
A new vectored vaccine MVA-VLP-SUDV was generated against Sudan ebolavirus (SUDV) combining the advantages of the immunogenicity of a live attenuated...
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Proof of concept for a single-dose Group B Streptococcus vaccine based on capsular polysaccharide conjugated to Qβ virus-like particles
A maternal vaccine to protect neonates against Group B Streptococcus invasive infection is an unmet medical need. Such a vaccine should ideally be...
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Vaccination with virus-like particles of atypical porcine pestivirus inhibits virus replication in tissues of BALB/c mice
Congenital tremor (CT) type A-II in piglets is a worldwide disease caused by an emerging atypical porcine pestivirus (APPV). Preparation and...
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Generation of Defective Interfering Particles of Morbilliviruses Using Reverse Genetics
RNA viruses generate defective genomes naturally during virus replication. Defective genomes that interfere with the infection dynamics either...
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Virus-like particle vaccinology, from bench to bedside
Virus-like particles (VLPs) have become key tools in biology, medicine and even engineering. After their initial use to resolve viral structures at...
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A recombinant virus-like particle vaccine against adenovirus-7 induces a potent humoral response
Adenoviruses (AdVs) cause infections in humans that range from mild to severe, and can cause outbreaks particularly in close contact settings....
