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Metagenomic search of viral coinfections in herpes simplex encephalitis patients
Little is known about concomitant central nervous system (CNS) infections by more than one virus. Current diagnostics are based on molecular tests...
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The mutation of Japanese encephalitis virus envelope protein residue 389 attenuates viral neuroinvasiveness
The envelope (E) protein of the Japanese encephalitis virus (JEV) is a key protein for virus infection and adsorption of host cells, which determines...
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Viral inhibitory potential of hyoscyamine in Japanese encephalitis virus–infected embryonated chicken eggs involving multiple signaling pathways
Japanese encephalitis virus (JEV) is the leading cause of viral encephalitis worldwide. The emergence of new genotypes of the virus and a high rate...
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Single-cell RNA sequencing reveals the immune features and viral tropism in the central nervous system of mice infected with Japanese encephalitis virus
Japanese encephalitis virus (JEV) is a neurotropic pathogen that causes lethal encephalitis. The high susceptibility and massive proliferation of JEV...
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Serum mir-142-3p release in children with viral encephalitis and its relationship with nerve injury and inflammatory response
Background: Viral encephalitis (VE) is a common infectious disease of the central nervous system in children. Children with severe disease may have...
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Intracellular Iron Accumulation Induces Inflammatory and Oxidative Status of the Host After Japanese Encephalitis Viral Infection
The factors mitigating the microglia/macrophage activation and inflammatory damage in Japanese encephalitis (JE) virus infected CNS are still being...
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A fatal case of viral sepsis and encephalitis in a child caused by human adenovirus type 7 infection
Adenoviruses are highly prevalent pathogens responsible for a wide range of clinical diseases, including respiratory tract infection, acute...
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Evolving etiologies, comorbidities, survival, and costs of care in adult encephalitis
Encephalitis is a central nervous system disorder, often caused by infectious agents or aberrant immune responses. We investigated causes,...
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A Novel Homozygous Mutation Causing Complete TYK2 Deficiency, with Severe Respiratory Viral Infections, EBV-Driven Lymphoma, and Jamestown Canyon Viral Encephalitis
Autosomal recessive tyrosine kinase 2 (TYK2) deficiency is characterized by susceptibility to mycobacterial and viral infections. Here, we report a...
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Role of inflammatory cytokine burst in neuro-invasion of Japanese Encephalitis virus infection: an immunotherapeutic approaches
Japanese Encephalitis remains a significant global health concern, contributing to millions of deaths annually worldwide. Microglial cells, as key...
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Learning from cerebrospinal fluid drug-resistant HIV escape-associated encephalitis: a case report
BackgroundIn the era of antiretroviral therapy (ART), central nervous system (CNS) complications in patients with human immunodeficiency virus (HIV)...
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Possible role of CNS microRNAs in Human Mpox virus encephalitis—a mini-review
In May 2022, a re-emerging viral pathogen belonging to the Poxviridae was first reported from the UK, and WHO confirmed the outbreak after the...
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Japanese Encephalitis Virus-Infected Cells
RNA virus infections have been a leading cause of pandemics. Aided by global warming and increased connectivity, their threat is likely to increase...
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Integrating DNA/RNA microbe detection and host response for accurate diagnosis, treatment and prognosis of childhood infectious meningitis and encephalitis
BackgroundInfectious meningitis/encephalitis (IM) is a severe neurological disease that can be caused by bacterial, viral, and fungal pathogens. IM...
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Brain Bioelectrical Activity in Children with Acute Viral Encephalitis
The aim of the present work was to evaluate changes in brain bioelectrical activity using electroencephalography (EEG) data in children with acute...
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Fighting Dengue, Chikungunya, and Japanese Encephalitis
My arbovirus career occurred in four stages, roughly 15 years each: US Army Medical Corps, University of Hawaii School of Medicine, Rockefeller...
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Molecular Mechanisms Associated with Neurodegeneration of Neurotropic Viral Infection
Viral infections of the central nervous system (CNS) cause variable outcomes from acute to severe neurological sequelae with increased morbidity and...
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Accidental acquisition of a rescued Japanese encephalitis virus with unspliced introns in the viral genome when using an intron-based stabilization approach
The intron-based stabilization approach is a very useful strategy for construction of stable flavivirus infectious clones. SA 14 -14-2 is a highly...
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Japanese encephalitis viral infection modulates proinflammatory cyto/chemokine profile in primary astrocyte and cell line of astrocytic origin
Japanese Encephalitis Virus (JEV) is a neurotropic virus that invades Central Nervous System (CNS) and causes severe neuroinflammation. Given the...
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Viral Haemorrhagic Fevers
Viral haemorrhagic diseases are complicated infections manifesting as an array of signs & symptoms. These involve a variety of viral species from...