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Multimodality imaging reveals angiogenic evolution in vivo during calvarial bone defect healing
The healing of calvarial bone defects is a pressing clinical problem that involves the dynamic interplay between angiogenesis and osteogenesis within...
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Magnetic resonance imaging-based approaches for detecting the efficacy of combining therapy following VEGFR-2 and PD-1 blockade in a colon cancer model
BackgroundAngiogenesis inhibitors have been identified to improve the efficacy of immunotherapy in recent studies. However, the delayed therapeutic...
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Evaluating the efficacy and microenvironment changes of HER2 + gastric cancer during HLX02 and Endostar treatment using quantitative MRI
Background and objectivesTrastuzumab is an important targeted drug for HER2-positive gastric cancer. The treatment efficacy of a more cost-effective...
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Vascular response patterns to targeted therapies in murine breast cancer models with divergent degrees of malignancy
BackgroundResponse assessment of targeted cancer therapies is becoming increasingly challenging, as it is not adequately assessable with conventional...
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Calliobothrium Narsisae n. sp. (Tetraphyllidea: Calliobothriidae) from the Triakid Shark Mustelus mosis Hemprich and Ehrenberg from the Persian Gulf, with a Note on Its Specific Proglottisation Process and a Key to the Species of the Genus
PurposeThe members of the tetraphyllidean genus Calliobothrium exhibit a high degree of host specificity in the shark genus Mustelus . In the Indian...
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Intrauterine inflammation and postnatal intravenous dopamine alter the neurovascular unit in preterm newborn lambs
BackgroundIntrauterine inflammation is considered a major cause of brain injury in preterm infants, leading to long-term neurodevelopmental deficits....
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Tertiary lymphoid structural heterogeneity determines tumour immunity and prospects for clinical application
Tertiary lymphoid structures (TLS) are clusters of immune cells that resemble and function similarly to secondary lymphoid organs (SLOs). While TLS...
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Metformin inhibits metastatic breast cancer progression and improves chemosensitivity by inducing vessel normalization via PDGF-B downregulation
BackgroundVascular maturity and functionality are closely associated with tumor progression and chemosensitivity. The antidiabetic agent metformin...
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Differences in Age-Related Changes in the Thymus in Rats Developmentally Exposed to Endocrine Disrupter Dichlorodiphenyltrichloroethane
We studied features of age-related changes in the thymus of mature male Wistar rats developmentally exposed to the endocrine disruptor...
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Beneficial effects of curcumin in the diabetic rat ovary: a stereological and biochemical study
This study aimed to investigate the effects of curcumin treatment on ovaries at different periods of the diabetes disease. Fifty-six female Wistar...
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Notch regulates vascular collagen IV basement membrane through modulation of lysyl hydroxylase 3 trafficking
Collagen type IV (Col IV) is a basement membrane protein associated with early blood vessel morphogenesis and is essential for blood vessel...
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Anagen hair follicles transplanted into mature human scars remodel fibrotic tissue
Despite the substantial impact of skin scarring on patients and the healthcare system, there is a lack of strategies to prevent scar formation, let...
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Atorvastatin pleiotropically decreases intraplaque angiogenesis and intraplaque haemorrhage by inhibiting ANGPT2 release and VE-Cadherin internalization
ObjectiveStatins pleiotropically provide additional benefits in reducing atherosclerosis, but their effects on intraplaque angiogenesis (IPA) and...
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G-CSF improved the memory and dendritic morphology impairments in the hippocampal CA1 pyramidal neurons after brain ischemia in the male rats
BackgroundStroke remains the leading cause of death and disability in the world. A new potential treatment for stroke is the granulocyte...
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Vascular normalisation as the step** stone into tumour microenvironment transformation
A functional vascular system is indispensable for drug delivery and fundamental for responsiveness of the tumour microenvironment to such medication....
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Neuroimaging of Small Vessel Disease in Late-Life Depression
Cerebral small vessel disease is associated with late-life depression, cognitive impairment, executive dysfunction, distress, and loss of life for...
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RUNX1 promotes angiogenesis in colorectal cancer by regulating the crosstalk between tumor cells and tumor associated macrophages
Colorectal cancer (CRC) is a common malignancy worldwide. Angiogenesis and metastasis are the critical hallmarks of malignant tumor. Runt-related...
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Micromechanical Force Measurement of Clotted Blood Particle Cohesion: Understanding Thromboembolic Aggregation Mechanisms
PurposeArterial shear forces may promote the embolization of clotted blood from the surface of thrombi, displacing particles that may occlude...
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Sequence-dependent synergistic effect of aumolertinib-pemetrexed combined therapy on EGFR-mutant non-small-cell lung carcinoma with pre-clinical and clinical evidence
BackgroundInevitably developed resistance of the third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) limited...
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Tumor vasculature remolding by thalidomide increases delivery and efficacy of cisplatin
BackgroundA promising strategy to overcome the chemoresistance is the tumor blood vessel normalization, which restores the physiological perfusion...
