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Effect of live-fire training on ventricular-vascular coupling
IntroductionCardiovascular events are a leading cause of firefighter duty-related death, with the greatest risk occurring during or shortly after...
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Mechano-Electric Coupling in the Heart: Effects on Heart Rate and Rhythm
Cardiac electrical and mechanical activity are closely interrelated, not only via the chain of events commonly referred to as ‘excitation-contraction...
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Electro-metabolic coupling in multi-chambered vascularized human cardiac organoids
The study of cardiac physiology is hindered by physiological differences between humans and small-animal models. Here we report the generation of...
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Role of Ca2+ in healthy and pathologic cardiac function: from normal excitation–contraction coupling to mutations that cause inherited arrhythmia
Calcium (Ca 2+ ) ions are a key second messenger involved in the rhythmic excitation and contraction of cardiomyocytes throughout the heart. Proper...
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14–3-3 protein regulation of excitation–contraction coupling
14–3-3 proteins (14–3-3 s) are a family of highly conserved proteins that regulate many cellular processes in eukaryotes by interacting with a...
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Sex differences in cardiovascular adaptations in recreational marathon runners
IntroductionThere are well-established sex differences in central hemodynamic and cardiac adaptations to endurance exercise; however, controversial...
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Intrinsic ecto-5'-Nucleotidase/A1R Coupling may Confer Neuroprotection to the Cerebellum in Experimental Autoimmune Encephalomyelitis
Experimental autoimmune encephalomyelitis (EAE) is widely used animal model of multiple sclerosis (MS). The disease is characterized by demyelination...
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A Dynamic Sheep Model to Induce Pulmonary Hypertension and Right Ventricular Failure
Decompensated right ventricular failure (RVF) in pulmonary hypertension (PH) is fatal, with limited medical treatment options. Develo** and testing...
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Remodeling of t-system and proteins underlying excitation-contraction coupling in aging versus failing human heart
It is well established that the aging heart progressively remodels towards a senescent phenotype, but alterations of cellular microstructure and...
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A century of exercise physiology: key concepts on coupling respiratory oxygen flow to muscle energy demand during exercise
After a short historical account, and a discussion of Hill and Meyerhof’s theory of the energetics of muscular exercise, we analyse steady-state rest...
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Dynamic Modulation of Device-Arterial Coupling to Determine Cardiac Output and Vascular Resistance
Clinical adoption of mechanical circulatory support for shock is rapidly expanding. Achieving optimal therapeutic benefit requires metrics of state...
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In Vivo Methods in Cardiovascular Safety Pharmacology
Cardiovascular safety pharmacology (SP) studies aim to define the proarrhythmic risk of a new chemical entity (NCE) and examine its potential effects...
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Protective Role of the AT1 Receptor in the Heart: A Biosensor of Stress
The renin angiotensin systemRenin angiotensin system plays an important role in blood pressure regulation and its primary component angiotensin...
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Human intracranial pulsatility during the cardiac cycle: a computational modelling framework
BackgroundToday’s availability of medical imaging and computational resources set the scene for high-fidelity computational modelling of brain...
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The Role of Endogenous Opioids in Cardioprotection
The opioid system involves opioid receptors (OPRs) and endogenous opioid peptides. This chapter will focus on the distribution of OPRs in the...
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Biomaterial-induced conversion of quiescent cardiomyocytes into pacemaker cells in rats
Pacemaker cells can be differentiated from stem cells or transdifferentiated from quiescent mature cardiac cells via genetic manipulation. Here we...
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Molecular Pathways and Animal Models of Cardiomyopathies
Cardiomyopathies are a heterogeneous group of disorders of the heart muscle that ultimately result in congestive heart failure. Rapid progress in...
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Inter- and Intracellular Signaling Pathways
Cardiovascular diseases, both congenital and acquired, are the leading cause of death worldwide, associated with significant health consequences and...
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Revolution in sepsis: a symptoms-based to a systems-based approach?
Severe infection and sepsis are medical emergencies. High morbidity and mortality are linked to CNS dysfunction, excessive inflammation, immune...
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Cardiovascular Physiopathology of Angiotensin II and Its Plasma and Nuclear Envelop Membranes’ Receptors
In 1934, the discovery of angiotensin IIAngiotensin II opened an Eldorado in the field of the cardiovascular system. Until today, this Eldorado is...