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Psychopharmacological properties and therapeutic profile of the antidepressant venlafaxine
Major depression (MD) is one of the most common psychiatric disorders worldwide. Currently, the first-line treatment for MD targets the serotonin...
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Passive Targeted Drug Delivery of Venlafaxine HCl to the Brain by Modified Chitosan Nanoparticles: Characterization, Cellular Safety Assessment, and In Vivo Evaluation
PurposesGeneralized anxiety is one of the most frequent anxiety problems. This study aimed to improve the distribution of venlafaxine HCl (Ven) in...
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Venlafaxine HCl Encapsulated in Niosome: Green and Eco-friendly Formulation for the Management of Pain
AbstractThe goal of this experimentation was to increase the cutaneous absorption of venlafaxine HCl (VFX) encapsulated in a niosome (venlasosme)...
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Physiologically Based Pharmacokinetic Modeling to Unravel the Drug-gene Interactions of Venlafaxine: Based on Activity Score-dependent Metabolism by CYP2D6 and CYP2C19 Polymorphisms
BackgroundVenlafaxine (VEN) is a commonly utilized medication for alleviating depression and anxiety disorders. The presence of genetic polymorphisms...
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Venlafaxine demonstrated anti-arthritic activity possibly through down regulation of TNF-α, IL-6, IL-1β, and COX-2
Venlafaxine is a serotonin-norepinephrine reuptake inhibitor used to treat depression. Previous studies demonstrated its anti-nociceptive and...
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Prenatal Venlafaxine Exposure–Induced Neurocytoarchitectural and Neuroapoptotic Degeneration in Striatum and Hippocampus of Develo** Fetal Brain, Manifesting Long-term Neurocognitive Impairments in Rat Offspring
Depression is a leading cause of disability which at its worst leads to suicide. Its treatment relies on psychotherapy in combination with certain...
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Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2D6, CYP2C19 and non-SSRI/non-TCA antidepressants
The Dutch Pharmacogenetics Working Group (DPWG) aims to facilitate pharmacogenetics implementation in clinical practice by develo** evidence-based...
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Age of onset for increased dose-adjusted serum concentrations of antidepressants and association with sex and genotype: An observational study of 34,777 individuals
PurposeThe aim of this study was to examine the age of onset for increased dose-adjusted serum concentrations (C/D ratio) of common antidepressant...
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The Effect of Chronic Mild Stress and Venlafaxine on the Expression and Methylation Levels of Genes Involved in the Tryptophan Catabolites Pathway in the Blood and Brain Structures of Rats
A growing body of evidence suggests that depression may be associated with impairment of the tryptophan catabolites (TRYCATs) pathway. The present...
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BDNF exon IV promoter methylation and antidepressant action: a complex interplay
BackgroundBDNF exon IV promoter methylation is a potential biomarker for treatment response to antidepressants in MDD. We have previously shown...
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Venlafaxine inhibits naloxone-precipitated morphine withdrawal symptoms: Role of inflammatory cytokines and nitric oxide
Opioid-induced neuroinflammation plays a role in the development of opioid physical dependence. Moreover, nitric oxide (NO) has been implicated in...
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Upregulation of antioxidant thioredoxin by antidepressants fluoxetine and venlafaxine
RationaleSelective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are the most commonly used drugs...
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Venlafaxine’s therapeutic reference range in the treatment of depression revised: a systematic review and meta-analysis
IntroductionThe selective serotonin and norepinephrine reuptake inhibitor venlafaxine is among the most prescribed antidepressant drugs worldwide...
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Role of JNK in the Regulation of Xenobiotic Metabolizing Function of Hepatocytes
We studied the role of JNK in the regulation of the metabolism of xenobiotic venlafaxine by liver cells under in vitro conditions. The inhibitory...
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Investigation of Serum Albumin Conformational Changes in Melancholic Depression under Pharmacotherapy Using Subnanosecond Fluorescent Spectroscopy
AbstractThe aim of the study was to investigate the serum albumin conformation in patients with melancholic depression. There were investigated 22...
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The effects of drug-drug interaction on linezolid pharmacokinetics: A systematic review
ObjectivesLinezolid is a commonly used antibiotic in the clinical treatment of gram-positive bacterial infections. The impacts of drug interactions...
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Identification of Potentially Repurposable Drugs for Lewy Body Dementia Using a Network-Based Approach
The conventional method of one drug being used for one target has not yielded therapeutic solutions for Lewy body dementia (LBD), which is a leading...
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Pharmacokinetics of venlafaxine in treatment responders and non-responders: a retrospective analysis of a large naturalistic database
PurposeTo assess in a large naturalistic sample, whether clinical response to a treatment with venlafaxine is associated with different patterns of...
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A patient-centred web-based adverse drug reaction reporting system identifies not yet labelled potential safety issues
PurposeReporting of adverse drug reactions (ADRs) by patients is essential for a comprehensive risk–benefit evaluation of drugs after marketing, but...