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Akt1-dependent expression of angiopoietin 1 and 2 in vascular smooth muscle cells leads to vascular stabilization
Retinal angiogenesis was delayed in VSMC-specific Akt1-deficient mice (Akt1 ∆SMC ) but not in Akt2 ∆SMC mice. The proliferation of ECs, recruitment of...
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Vascular Endothelium
The endothelium is strategically located at the interface between the blood flow and the vascular smooth muscle and other components of the vessel...
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β1 integrins play a critical role maintaining vascular integrity in the hypoxic spinal cord, particularly in white matter
Interactions between extracellular matrix (ECM) proteins and β1 integrins play an essential role maintaining vascular integrity in the brain,...
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The Provenance, Providence, and Position of Endothelial Cells in Injured Spinal Cord Vascular Pathology
Endothelial cells (ECs) and pericytes are present in all blood vessels. Their position confers an important role in controlling oxygen and nutrient...
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Exercise and vascular function in sedentary lifestyles in humans
People with sedentary lifestyles engage in minimal or no physical activity. A sedentary lifestyle promotes dysregulation of cellular redox balance,...
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Endothelial deubiquinatase YOD1 mediates Ang II-induced vascular endothelial-mesenchymal transition and remodeling by regulating β-catenin
Hypertension is a prominent contributor to vascular injury. Deubiquinatase has been implicated in the regulation of hypertension-induced vascular...
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Vascular calcification: from the perspective of crosstalk
Vascular calcification (VC) is highly correlated with cardiovascular disease morbidity and mortality, but anti-VC treatment remains an area to be...
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Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer’s disease
Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular injuries in cerebral large and small vessels and is a key driver of...
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PRMT3 methylates HIF-1α to enhance the vascular calcification induced by chronic kidney disease
BackgroundMedial vascular calcification is commonly identified in chronic kidney disease (CKD) patients and seriously affects the health and life...
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P53 in Vascular Remodeling: The Potential for Targeting in Atherosclerosis
PurposeAt first, p53 was believed to be present primarily in malignant cells. In fact, p53 turned out to play a major role in vascular remodeling...
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Blockade of sympathetic ganglia improves vascular dysfunction in septic shock
Sepsis/septic shock activates the sympathetic nervous system (SNS) to deal with the infection stress. However, an imbalanced or maladaptive response...
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Vascular response patterns to targeted therapies in murine breast cancer models with divergent degrees of malignancy
BackgroundResponse assessment of targeted cancer therapies is becoming increasingly challenging, as it is not adequately assessable with conventional...
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Preoperative embolization of renal cell carcinoma metastases to the bone prior to stabilization procedures does not result in reduction in intraoperative blood loss
PurposeThe effect of preoperative embolization of bone metastases prior to stabilization procedures in reducing intraoperative blood loss remains...
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Expression of Vascular Endothelial Growth Factor at High Altitude
Oxygen plays an important role in aerobic respiration in mammals. However, there is subsequent decrease in partial pressure of oxygen with increase...
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Development of vascular disease models to explore disease causation and pathomechanisms of rare vascular diseases
As the field of medicine is striving forward heralded by a new era of next-generation sequencing (NGS) and integrated technologies such as...
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Innovation in Stabilization of Biopharmaceuticals
The applications of biopharmaceuticals, therapeutic molecules of biological origin, are increasing every day. The major reasons for this preference...
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Pericyte, but not astrocyte, hypoxia inducible factor-1 (HIF-1) drives hypoxia-induced vascular permeability in vivo
BackgroundWays to prevent disease-induced vascular modifications that accelerate brain damage remain largely elusive. Improved understanding of...
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Oxidative stress and epigenetics in ocular vascular aging: an updated review
Vascular aging is an inevitable process with advancing age, which plays a crucial role in the pathogenesis of cardiovascular and microvascular...
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Vascular hyperacetylation is associated with vascular smooth muscle dysfunction in a rat model of non-obese type 2 diabetes
BackgroundAdvanced type 2 diabetes mellitus (T2DM) accelerates vascular smooth muscle cell (VSMC) dysfunction which contributes to the development of...
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Metabolism of Vascular Smooth Muscle
Metabolism refers to chemical reactions that take place in an organism to maintain its structure and activities, to respond to environment changes,...