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Physiologically relevant platform for an advanced in vitro model of the vascular wall: focus on in situ fabrication and mechanical maturation
The mechanical stimulation applied on engineered vascular constructs in perfusion bioreactors has been shown to be beneficial for their maturation....
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Renin Angiotensin System in the Maturation and Failure of Arterio-Venous Fistula
An arteriovenous fistulaArteriovenous fistula (AVF) is the most used vascular access for hemodialysis but is associated with failure occurring within...
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Temporal regulation of notch activation improves arteriovenous fistula maturation
BackgroundArteriovenous fistula (AVF) maturation is a process involving remodeling of venous arm of the AVFs. It is a challenge to balance adaptive...
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Coalescent angiogenesis—evidence for a novel concept of vascular network maturation
Angiogenesis describes the formation of new blood vessels from pre-existing vascular structures. While the most studied mode of angiogenesis is...
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Human neuronal maturation comes of age: cellular mechanisms and species differences
The delayed and prolonged postmitotic maturation of human neurons, compared with neurons from other species, may contribute to human-specific...
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Flow-induced high frequency vascular wall vibrations in an arteriovenous fistula: a specific stimulus for stenosis development?
Hemodialysis is the lifeline for nearly three million end stage renal disease patients worldwide. Native arteriovenous fistula (AVF) is the preferred...
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Extracellular Vesicles and Vascular Inflammation
Vascular inflammation is the most common pathological feature in the pathogenesis of human disease. It is a complex immune process involved with many...
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Treatment with Atorvastatin During Vascular Remodeling Promotes Pericyte-Mediated Blood-Brain Barrier Maturation Following Ischemic Stroke
We previously showed that newly formed vessels in ischemic rat brain have high blood-brain barrier (BBB) permeability at 3 weeks after stroke due to...
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Brain Maturation as a Fundamental Factor in Immune-Neurovascular Interactions in Stroke
Injuries in the develo** brain cause significant long-term neurological deficits. Emerging clinical and preclinical data have demonstrated that the...
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Vascular Endothelium
The endothelium is strategically located at the interface between the blood flow and the vascular smooth muscle and other components of the vessel...
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Selected commensals educate the intestinal vascular and immune system for immunocompetence
BackgroundThe intestinal microbiota fundamentally guides the development of a normal intestinal physiology, the education, and functioning of the...
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Harnessing conserved signaling and metabolic pathways to enhance the maturation of functional engineered tissues
The development of induced-pluripotent stem cell (iPSC)-derived cell types offers promise for basic science, drug testing, disease modeling,...
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Cuproptosis and copper deficiency in ischemic vascular injury and repair
Ischemic vascular diseases are on the rise globally, including ischemic heart diseases, ischemic cerebrovascular diseases, and ischemic peripheral...
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Human dendritic cell maturation induced by amorphous silica nanoparticles is Syk-dependent and triggered by lipid raft aggregation
BackgroundSynthetic amorphous silica nanoparticles (SAS-NPs) are widely employed in pharmaceutics, cosmetics, food and concretes. Workers and the...
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β1 integrins play a critical role maintaining vascular integrity in the hypoxic spinal cord, particularly in white matter
Interactions between extracellular matrix (ECM) proteins and β1 integrins play an essential role maintaining vascular integrity in the brain,...
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The maturation of iPS cell-derived brain microvascular endothelial cells by inducible-SOX18 expression
BackgroundBrain microvascular endothelial cells (BMECs) play a major role in the blood–brain barrier (BBB), and are critical for establishing an in...
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Sterile inflammation in the pathogenesis of maturation failure of arteriovenous fistula
Chronic kidney disease is a widespread terminal illness that afflicts millions of people across the world. Hemodialysis is the predominant...
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β1 integrin is essential for blood–brain barrier integrity under stable and vascular remodelling conditions; effects differ with age
BackgroundMaintaining a tight blood–brain barrier (BBB) is an important prerequisite for the preservation of neurological health, though current...
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Metabolically driven maturation of human-induced-pluripotent-stem-cell-derived cardiac microtissues on microfluidic chips
The immature physiology of cardiomyocytes derived from human induced pluripotent stem cells (hiPSCs) limits their utility for drug screening and...
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Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer’s disease
Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular injuries in cerebral large and small vessels and is a key driver of...
