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Biomechanical Remodeling of Aortic Valve Interstitial Cells During Calcified Lesion Formation In Vitro
Healthy aortic heart valves are essential to the regulation of unidirectional blood flow. Calcific aortic valve disease (CAVD) is an actively...
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circ-CCND1 regulates the CCND1/P53/P21 pathway through sponging miR-138-5p in valve interstitial cells to aggravate aortic valve calcification
To discuss the effect and mechanism of circular-CCND1 (circ-CCND1) on the regulation of calcified aortic valve disease (CAVD). Differentially...
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Inhibition of miR-101-3p prevents human aortic valve interstitial cell calcification through regulation of CDH11/SOX9 expression
BackgroundCalcific aortic valve disease (CAVD) is the second leading cause of adult heart diseases. The purpose of this study is to investigate...
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Heart Valve Regeneration
The valves of the heart cannot regenerate spontaneously. Therefore, heart valve disease generally necessitates surgical repair or replacement of the...
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Monocytes augment inflammatory responses in human aortic valve interstitial cells via β2-integrin/ICAM-1-mediated signaling
ObjectiveInflammatory infiltration in aortic valves promotes calcific aortic valve disease (CAVD) progression. While soluble extracellular matrix...
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Chondroitin Sulfate Promotes Interstitial Cell Activation and Calcification in an In Vitro Model of the Aortic Valve
PurposeCalcific aortic valve disease (CAVD), has been characterized as a cascade of cellular changes leading to leaflet thickening and valvular...
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Metformin alleviates the calcification of aortic valve interstitial cells through activating the PI3K/AKT pathway in an AMPK dependent way
BackgroundCalcific aortic valve disease (CAVD) is the most prevalent valvular disease worldwide. However, no effective treatment could delay or...
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LncRNA AFAP1-AS1 promotes M1 polarization of macrophages and osteogenic differentiation of valve interstitial cells
Little is known about the biological functions and underlying mechanisms of long non-coding RNA AFAP1-AS1 in degenerative calcified aortic valve...
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Noncoding RNA regulates the expression of Krm1 and Dkk2 to synergistically affect aortic valve lesions
Calcific aortic valve disease (CAVD) is becoming an increasingly important global medical problem, but effective pharmacological treatments are...
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Advanced glycation end product-modified low-density lipoprotein promotes pro-osteogenic reprogramming via RAGE/NF-κB pathway and exaggerates aortic valve calcification in hamsters
BackgroundAdvanced glycation end product-modified low-density lipoprotein (AGE-LDL) is related to inflammation and the development of...
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The role of neutrophil elastase in aortic valve calcification
BackgroundCalcific aortic valve disease (CAVD) is the most commonly valvular disease in the western countries initiated by inflammation and abnormal...
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Identification of Circulating Inflammatory Proteins Associated with Calcific Aortic Valve Stenosis by Multiplex Analysis
Calcific aortic valve stenosis (CAVS) is characterized by increasing inflammation and progressive calcification in the aortic valve leaflets and is a...
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RNA-sequencing of human aortic valves identifies that miR-629-3p and TAGLN miRNA-mRNA pair involving in calcified aortic valve disease
This study aimed to uncover the microRNA and messenger RNA (miRNA/mRNA) interactions in the pathophysiological process of calcified aortic valve...
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The Individual and Combined Effects of Shear, Tension, and Flexure on Aortic Heart Valve Endothelial Cells in Culture
PurposeThe necessity of living engineered heart valves to treat patients with severe heart disease poses a challenge to tissue engineers. To reach...
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Epigenetic age acceleration and risk of aortic valve stenosis: a bidirectional Mendelian randomization study
BackgroundAortic valve stenosis (AVS) is the most prevalent cardiac valve lesion in developed countries, and pathogenesis is closely related to...
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Pro-inflammatory mediators released by activated monocytes promote aortic valve fibrocalcific activity
BackgroundCalcific aortic valve disease (CAVD) is the most prevalent heart valve disorder in the elderly. Valvular fibrocalcification is a...
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Fibrosis and expression of extracellular matrix proteins in human interventricular septum in aortic valve stenosis and regurgitation
Valvular heart disease leads to ventricular pressure and/or volume overload. Pressure overload leads to fibrosis, which might regress with its...
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Screening of immune-related secretory proteins linking chronic kidney disease with calcific aortic valve disease based on comprehensive bioinformatics analysis and machine learning
BackgroundChronic kidney disease (CKD) is one of the most significant cardiovascular risk factors, playing vital roles in various cardiovascular...
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Simulation of Mitral Valve Plasticity in Response to Myocardial Infarction
Left ventricular myocardial infarction (MI) has broad and debilitating effects on cardiac function. In many cases, MI leads to ischemic mitral...
