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An engineered HIV-1 Gag-based VLP displaying high antigen density induces strong antibody-dependent functional immune responses
Antigen display on the surface of Virus-Like Particles (VLPs) improves immunogenicity compared to soluble proteins. We hypothesised that immune...
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Construction of Higher-Order VLP-Based Materials and Their Effect on Diffusion and Partitioning
In spite of their role as harmful infectious entities, viruses have gained a significant research attention as they can be exploited as nanomaterials...
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A VLP for validation of the Plasmodium falciparum circumsporozoite protein junctional epitope for vaccine development
Malaria continues to be a pressing global health issue, causing nearly half a million deaths per year. An effective malaria vaccine could radically...
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A multiclade env–gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of heterologous SHIV infection in macaques
The development of a protective vaccine remains a top priority for the control of the HIV/AIDS pandemic. Here, we show that a messenger RNA (mRNA)...
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One-Step Purification Strategy for Cowpea Chlorotic Mottle Virus-Like Particles Produced by the IC-BEVS
Virus-like particles (VLP) of the cowpea chlorotic mottle virus (CCMV), a plant virus, have been shown to be safe and noncytotoxic vehicles for...
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Analyzing atomic force microscopy images of virus-like particles by expectation-maximization
Analysis of virus-like particles (VLPs) is an essential task in optimizing their implementation as vaccine antigens for virus-initiated diseases....
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Expression of dengue virus and Zika virus NS2B-NS3pro constructs alter cellular fatty acids, but co-expression with a Zika virus virus-like particle is detrimental to virus-like particle expression
ObjectiveStudies have shown that Flavivirus infection remodels the host cell to favour viral replication. In particular, the host cell lipid profile...
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A nanoparticle vaccine displaying the ookinete PSOP25 antigen elicits transmission-blocking antibody response against Plasmodium berghei
BackgroundSafe and effective vaccines are crucial for the control and eventual elimination of malaria. Novel approaches to optimize and improve...
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Hemagglutinin virus-like particles incorporated with membrane-bound cytokine adjuvants provide protection against homologous and heterologous influenza virus challenge in aged mice
BackgroundCurrent influenza vaccines deliver satisfactory results in young people but are less effective in the elderly. Development of vaccines for...
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A virus-like particle-based bivalent PCSK9 vaccine lowers LDL-cholesterol levels in non-human primates
Elevated low-density lipoprotein cholesterol (LDL-C) is an important risk factor in the development of atherosclerotic cardiovascular disease...
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Advancing usability of an influenza hemagglutinin virus-like particle vaccine expressing a chimeric cytokine
Vaccine efficacy of conventional influenza vaccines depend on the antigenic similarity between the selected vaccine strain and annual epidemic...
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Ebola virus–like particles reprogram cellular metabolism
AbstractEbola virus can trigger a release of pro-inflammatory cytokines with subsequent vascular leakage and impairment of clotting finally leading...
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VLPs containing stalk domain and ectodomain of matrix protein 2 of influenza induce protection in mice
BackgroundAs a result of antigenic drift, current influenza vaccines provide limited protection against circulating influenza viruses, and vaccines...
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Design of hepadnavirus core protein-based chimeric virus-like particles carrying epitopes from respiratory syncytial virus
Respiratory syncytial virus (RSV) is one of the most important pathogens causing respiratory tract infection in humans, especially in infants and the...
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Elimination of receptor binding by influenza hemagglutinin improves vaccine-induced immunity
The binding of influenza hemagglutinin (HA) to sialic acid (SA) receptors plays a well-defined role in sha** infection but the impact of such...
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A single immunization with a modified vaccinia Ankara vectored vaccine producing Sudan virus-like particles protects from lethal infection
A new vectored vaccine MVA-VLP-SUDV was generated against Sudan ebolavirus (SUDV) combining the advantages of the immunogenicity of a live attenuated...
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Recent Advancements and Challenges in Recombinant Expression for Commercial Production of Virus-Like Particles (VLPs)
Virus-like particles (VLPs) are mimics of native viruses that are generated from the self-assembly of viral structural proteins. The particles lack...
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Impact of the SARS-CoV-2 nucleocapsid 203K/204R mutations on the inflammatory immune response in COVID-19 severity
BackgroundThe excessive inflammatory responses provoked by SARS-CoV-2 infection are critical factors affecting the severity and mortality of...
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Generation of porcine circovirus type 4 virus-like particles and their use to detect serum antibodies
Porcine circovirus type 4 (PCV4), first identified in 2019 as a newly emerging pathogen, has been found in several provinces of China, as well as in...
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Evaluation of novel Epstein-Barr virus-derived antigen formulations for monitoring virus-specific T cells in pediatric patients with infectious mononucleosis
BackgroundInfection with the Epstein-Barr virus (EBV) elicits a complex T-cell response against a broad range of viral proteins. Hence, identifying...
