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1. Study on structure-activity relationship (SAR) of simplified mirogabalin derivatives as voltage-gated calcium channel α2δ ligands for the treatment of chronic neuropathic pain

   A clinical therapy for chronic neuropathic pain is urgently needed, and the voltage-gated calcium channel (VGCC) α2δ subunit is among the most...

   Yuanwen Zhang, Yueming Zheng, ... Huihui Ti in Medicinal Chemistry Research

   Article 26 December 2022
   

2. Immune-Mediated Cerebellar Ataxias

   Immune-mediated cerebellar ataxias (IMCAs) have diverse etiologies. Paraneoplastic cerebellar degeneration, gluten ataxia, and primary autoimmune...

   Marios Hadjivassiliou, Hiroshi Mitoma in Essentials of Cerebellum and Cerebellar Disorders

   Chapter 2023
   

3. Inhibitory effects on L- and N-type calcium channels by a novel Ca_Vβ₁ variant identified in a patient with autism spectrum disorder

   Voltage-gated calcium channel (VGCC) subunits have been genetically associated with autism spectrum disorders (ASD). The properties of the...

   Patrick Despang, Sarah Salamon, ... Jan Matthes in Naunyn-Schmiedeberg's Archives of Pharmacology

   Article Open access 05 February 2022
   

4. The Mechanism of α2 adrenoreceptor-dependent Modulation of Neurotransmitter Release at the Neuromuscular Junctions

   α2-Adrenoreceptors (ARs) are main G _i -protein coupled autoreceptors in sympathetic nerve terminals and targets for dexmedetomidine (DEX), a widely...

   Andrei N. Tsentsevitsky, Venera F. Khuzakhmetova, ... Alexey M. Petrov in Neurochemical Research

   Article 28 October 2023
   

5. Involvement of the Voltage-Gated Calcium Channels L- P/Q- and N-Types in Synapse Elimination During Neuromuscular Junction Development

   During the nervous system development, synapses are initially overproduced. In the neuromuscular junction (NMJ) however, competition between several...

   Neus Garcia, Pablo Hernández, ... Josep Tomàs in Molecular Neurobiology

   Article Open access 27 April 2022
   

6. The CACNA1A Mutant Disrupts Lysosome Calcium Homeostasis in Cerebellar Neurons and the Resulting Endo-Lysosomal Fusion Defect Can be Improved by Calcium Modulation

   Mutations in P/Q type voltage gated calcium channel (VGCC) lead severe human neurological diseases such as episodic ataxia 2, familial hemiplegic...

   Feng Zhu, Yun** Miao, ... Xuejun Tian in Neurochemical Research

   Article 02 September 2021
   

7. Muscarinic Receptors in Developmental Axonal Competition at the Neuromuscular Junction

   In recent years, we have studied by immunohistochemistry, intracellular recording, and western blotting the role of the muscarinic acetylcholine...

   Josep Tomàs, Maria A. Lanuza, ... Neus Garcia in Molecular Neurobiology

   Article Open access 17 December 2022
   

8. Advances in the Pathogenesis of Auto-antibody-Induced Cerebellar Synaptopathies

   The presence of auto-antibodies that target synaptic machinery proteins was documented recently in immune-mediated cerebellar ataxias. The...

   Hiroshi Mitoma, Mario Manto in The Cerebellum

   Article Open access 22 January 2022
   

9. Critical Pronociceptive Role of Family 2 Voltage-Gated Calcium Channels in a Novel Mouse Model of HIV-Associated Sensory Neuropathy

   Some people living with HIV present painful sensory neuropathy (HIV-SN) that is pharmacoresistant, sex-associated, and a major source of morbidity....

   Debora Denardin Lückemeyer, Arthur Silveira Prudente, ... Juliano Ferreira in Molecular Neurobiology

   Article 09 February 2023
   

10. Cerebellar long-term depression and auto-immune target of auto-antibodies: the concept of LTDpathies

    There is general agreement that auto-antibodies against ion channels and synaptic machinery proteins can induce limbic encephalitis. In...

    Hiroshi Mitoma, Jerome Honnorat, ... Mario Manto in Molecular Biomedicine

    Article Open access 10 January 2021
    

11. Systemic, Intrathecal, and Intracerebroventricular Antihyperalgesic Effects of the Calcium Channel Blocker CTK 01512–2 Toxin in Persistent Pain Models

    CTK 01512–2 toxin is a recombinant peptide of the Phα1β version derived from the venom of the Phoneutria nigriventer spider. It acts as an N-type...

    Juliana Cavalli, Pollyana Mendonça de Assis, ... Rafael Cypriano Dutra in Molecular Neurobiology

    Article 16 May 2022
    

12. Mouse aortic biomechanics are affected by short-term defective autophagy in vascular smooth muscle cells

    The physiology of vascular smooth muscle (VSMC) cells is affected by autophagy, a catabolic cellular mechanism responsible for nutrient recycling....

    Dorien G. De Munck, Arthur J. A. Leloup, ... Paul Fransen in The Journal of Physiological Sciences

    Article Open access 11 March 2022
    

13. Expression and functions of N-type Cav2.2 and T-type Cav3.1 channels in rat vasopressin neurons under normotonic conditions

    Arginine vasopressin (AVP) neurons play essential roles in sensing the change in systemic osmolarity and regulating AVP release from their neuronal...

    Kaori Sato-Numata, Tomohiro Numata, ... Yasunobu Okada in The Journal of Physiological Sciences

    Article Open access 15 October 2020
    

14. Brain-derived neurotrophic factor produced long-term synaptic enhancement in the anterior cingulate cortex of adult mice

    Previous studies have demonstrated that brain-derived neurotrophic factor (BDNF) is one of the diffusible messengers for enhancing synaptic...

    Hui-Hui Miao, Zhuang Miao, ... Min Zhuo in Molecular Brain

    Article Open access 15 September 2021
    

15. Anoctamin 1 antagonism potentiates conventional tocolytic-mediated relaxation of pregnant human uterine smooth muscle

    Background

    Currently available tocolytic agents are not effective treatment for preterm labor beyond 48 h. A major reason is the development of...

    Shunsuke Hyuga, Robert C. Parry, ... George Gallos in The Journal of Physiological Sciences

    Article Open access 22 February 2021
    

16. Trimethyltin Increases Intracellular Ca²⁺ Via L-Type Voltage-Gated Calcium Channels and Promotes Inflammatory Phenotype in Rat Astrocytes In Vitro

    Astrocytes are the first responders to noxious stimuli by undergoing cellular and functional transition referred as reactive gliosis. Every acute or...

    Milorad Dragić, Katarina Milićević, ... Nadežda Nedeljković in Molecular Neurobiology

    Article 04 January 2021
    

17. Computational model of the spatiotemporal synergetic system dynamics of calcium, IP₃ and dopamine in neuron cells

    The functioning of several cellular processes in neuron cells relies on the interplay between multiple systems, such as calcium ([Ca ²⁺ ]), inositol 1,...

    Anand Pawar, Kamal Raj Pardasani in Cognitive Neurodynamics

    Article 06 May 2024
    

18. Regulation of Presynaptic Calcium Channels

    Voltage-gated calcium channels (VGCCs), especially Cav2.1 and Cav2.2, are the major mediators of Ca2+ influx at the presynaptic membrane in response...

    Pengyu Zong, Lixia Yue in Molecular Mechanisms of Neurotransmitter Release

    Chapter 2023
    

19. Molecular, immunological, and physiological evidences of a sphingosine-activated plasma membrane Ca²⁺-channel in Trypanosoma equiperdum

    The hemoparasite Trypanosoma equiperdum belongs to the Trypanozoon subgenus and includes several species that are pathogenic to animals and humans in...

    M. C. Pérez-Gordones, J. R. Ramírez-Iglesias, ... M. Mendoza in Parasitology Research

    Article 20 March 2024
    

20. Neuroimmune Mechanisms of Cerebellar Ataxias

    This chapter discusses cell- and autoantibody-mediated immune mechanisms impairing cerebellar neurons and circuits. Various autoimmune processes...

    Hiroshi Mitoma, Mario Manto in Essentials of Cerebellum and Cerebellar Disorders

    Chapter 2023