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Modelling urea cycle disorders using iPSCs
The urea cycle is a liver-based pathway enabling disposal of nitrogen waste. Urea cycle disorders (UCDs) are inherited metabolic diseases caused by...
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p53 inhibits the Urea cycle and represses polyamine biosynthesis in glioma cell lines
Glioma is the most common malignant tumor of the central nervous system. The urea cycle (UC) is an essential pathway to convert excess nitrogen and...
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Combination of tea catechins and ornithine effectively activates the urea cycle: an in vitro and human pilot study
PurposeAccumulation of ammonia causes central and peripheral fatigue. This study aimed to investigate the synergistic effect of tea catechins and...
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A Photocatalytic Method for Elimination of Urea
Different approaches to the implementation of photocatalytic elimination of urea in aqueous solutions are considered. The main advantages and...
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Ammonia detoxification promotes CD8+ T cell memory development by urea and citrulline cycles
Amino acid metabolism is essential for cell survival, while the byproduct ammonia is toxic and can injure cellular longevity. Here we show that CD8 + ...
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Analysis of nucleotide insertion opposite urea and translesion synthesis across urea by DNA polymerases
AbstractUrea (Ua) is produced in DNA as the result of oxidative damage to thymine and guanine. It was previously reported that Klenow fragment (Kf)...
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Studies of Photocatalytic Hydrolysis of Urea in Dialysis Solution in the Near UV Range
We present here the results of studies of a photocatalytic method for hydrolysis of urea in model solutions of treated dialysate. This work used a...
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Synthesis and pharmacological evaluation of new disulfides linked to 1,2,4-triazole bearing urea moiety
The present work involves the synthesis of a series of new disulfides linked to 1,2,4-triazole bearing urea moiety through multistep reaction. The in...
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Metabolomic profiling of maternal plasma identifies inverse associations of acetate and urea with anti-SARS-CoV-2 antibody titers following COVID-19 vaccination during pregnancy
AbstractWe conducted a comprehensive metabolomic analysis of plasma samples obtained from pregnant women who displayed varying post-vaccination...
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Low Cu(II) Concentration Detection Based on Fluorescent Detector Made from Citric Acid and Urea
Carbon quantum dots (CQD) are an advanced fluorescent material, which has attracted more and more attention in theoretical research and practical...
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Synthesis and biological evaluation of new thiazolyl-urea derivatives as potential dual C-RAF/FLT3 inhibitors
Based on a structure-activity relationship of compounds such as Sorafenib and Quizartinib, a series of thiazol-urea derivatives containing...
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Patient stratification based on urea cycle metabolism for exploration of combination immunotherapy in colon cancer
BackgroundOwing to the low ratio of patients benefitting from immunotherapy, patient stratification becomes necessary. An accurate patient...
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Anticancer and antimicrobial activities of new thiazolyl-urea derivatives: gene expression, DNA damage, DNA fragmentation and SAR studies
The drug resistance became the major challenge in the antimicrobial and anticancer drugs therapy. Therefore, there is an urgent need to looking for...
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The New Class of Diagnostic Systems Based on Polyelectrolyte Microcapsules for Urea Detection
The chapter describes new diagnosticdiagnostic systems for analysis of urea concentration based on polyelectrolyte microcapsulespolyelectrolyte...
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Attenuation of CFA-induced chronic inflammation by a bicyclic monoterpene fenchone targeting inducible nitric oxide, prostaglandins, C-reactive protein and urea
Fenchone (a bicyclic monoterpene) is present in the essential oils of plant species like Foeniculum vulgare and Peumus boldus and is used to treat...
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Formulation and Characterization of Interpenetrating Polymer Network Hydrogel Bead as Drug Carrier System for Extended Release of Sulphonyl Urea Medication
PurposeThe study aims to develop an interpenetrating polymer network (IPN) hydrogel bead. This drug carrier system with a hydrophilic polymer is...
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Inhibition of Urea Transporter (UT)-B Modulates LPS-Induced Inflammatory Responses in BV2 Microglia and N2a Neuroblastoma Cells
Urea is the major nitrogen-containing product of protein metabolism, and the urea cycle is intrinsically linked to nitric oxide (NO) production via...
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Urea Transporters in Health and Disease
Urea transporters are a relatively recent discovery in the overall history of kidney physiology. Urea transport proteins were first proposed in the...
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Physicomechanical, stability, and pharmacokinetic evaluation of aceclofenac dimethyl urea cocrystals
Poor physicomechanical properties and limited aqueous solubility restrict the bioavailability of aceclofenac when given orally. To improve its above...
