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Parathyroid hormone stimulates bone regeneration in an atrophic non-union model in aged mice
BackgroundNon-union formation still represents a major burden in trauma and orthopedic surgery. Moreover, aged patients are at an increased risk for...
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Development of a Head Acceleration Event Classification Algorithm for Female Rugby Union
Instrumented mouthguards have been used to detect head accelerations and record kinematic data in numerous sports. Each recording requires validation...
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Sildenafil, a phosphodiesterase-5 inhibitor, stimulates angiogenesis and bone regeneration in an atrophic non-union model in mice
Non-union formation represents a major complication in trauma and orthopedic surgery. The phosphodiesterase-5 (PDE-5) inhibitor sildenafil has been...
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The vascularization paradox of non-union formation
Despite major research efforts to elucidate mechanisms of non-union formation, failed fracture healing remains a common complication in orthopedic...
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Physical Characteristics Explain Ball-Carrying Capability in Sub-Elite Rugby Union Players
PurposeThe aims of the present study were two-fold: (i) to investigate the relationship between physical characteristics and the game statistics...
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Air (ine)quality in the European Union
Purpose of ReviewThis paper presents an analytical review of recent research on social inequality caused or compounded by ambient air pollution in...
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Prediction Criteria for the Formation of Refracture after Union of a Long Bone Fracture on the Basis of Hemodynamic Changes in the Tissues of the Area of Damage
We studied hemodynamic changes in the area of leg bone fracture and determined the prognostic criteria for refracture formation after achieved union....
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Ethics and regulation of neuronal optogenetics in the European Union
Neuronal optogenetics is a technique to control the activity of neurons with light. This is achieved by artificial expression of light-sensitive ion...
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Current status of neoadjuvant therapy for locally advanced rectal cancer in Wuhan Union Hospital Cancer Center
BackgroundTo analyze and explore the evolution and short-term efficacy of neoadjuvant therapy for patients with mid and low LARC in Wuhan Union...
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Climatic Factors and Allele Distribution of Amy 1 and Amy 2 Loci in the Varieties of Spring Barley in the Territory of the Former Soviet Union
AbstractThe alpha-amylase isozymes in barley are controlled by the Amy 1 and Amy 2 loci located on chromosomes 6 and 1 (=6H and 7H), respectively....
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Analysis and comparative evaluation of expedited programs for gene therapy products: insights from the United States, the European Union, Japan, and South Korea
Gene therapy products (GTPs) used for incurable diseases can be expedited for early commercialization to fulfill unmet needs. This study analyzed the...
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Candidate Bevacizumab Biosimilar CT-P16 versus European Union Reference Bevacizumab in Patients with Metastatic or Recurrent Non-Small Cell Lung Cancer: A Randomized Controlled Trial
BackgroundCT-P16 is a candidate bevacizumab biosimilar.
ObjectiveThis double-blind, multicenter, parallel-group, phase III study aimed to establish...
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Human Inborn Errors of Immunity: 2022 Update on the Classification from the International Union of Immunological Societies Expert Committee
We report the updated classification of inborn errors of immunity, compiled by the International Union of Immunological Societies Expert Committee....
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Perceptions and Attitudes Towards Shoulder Padding and Shoulder Injury in Rugby Union
PurposeTo develop an understanding of the role of shoulder padding in rugby union by investigating player perceptions and attitudes towards shoulder...
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Chaos to Clarity: Pragmatic Approaches to Overcome Challenges for Successful Implementation of Additional Risk Minimisation Measures in the European Union and the UK by a Marketing Authorisation Holder
BackgroundMost national competent authorities issue guidance on the dissemination and implementation of additional risk minimisation measures...
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Regulatory Approval Scenario of Biosimilars in Pediatric Patients in the United States and European Union
Regulatory agencies of the USA and European Union (EU) have introduced multiple guidelines in the last decade to standardize and accelerate...
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Effectiveness of Additional Risk Minimization Measures for Atezolizumab in the European Union
BackgroundA Guide for Healthcare Professionals (HCP Guide) and patient alert card (PAC) for atezolizumab as additional risk minimization measures for...
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Bioinformatics Analysis and Experimental Validation of Differential Genes and Pathways in Bone Nonunions
Non-union fractures pose a significant clinical challenge, often leading to prolonged pain and disability. Understanding the molecular mechanisms...
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Inflammatory processes and elevated osteoclast activity chaperon atrophic non-union establishment in a murine model
BackgroundDelayed bone healing, especially in long bones poses one of the biggest problems in orthopeadic and reconstructive surgery and causes...
