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Comparative oncology reveals DNMT3B as a molecular vulnerability in undifferentiated pleomorphic sarcoma
PurposeUndifferentiated pleomorphic sarcoma (UPS), an aggressive subtype of soft-tissue sarcoma (STS), is exceedingly rare in humans and lacks...
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PTEN pathogenic variants are associated with poor prognosis in patients with advanced soft tissue sarcoma
BackgroundWe aimed to examine whether PTEN pathogenic variants (mutPTEN) were associated with overall survival (OS) in patients with advanced soft...
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Etiopathogenic role of ERK5 signaling in sarcoma: prognostic and therapeutic implications
Sarcomas constitute a heterogeneous group of rare and difficult-to-treat tumors that can affect people of all ages, representing one of the most...
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Good and sustained response to pembrolizumab and pazopanib in advanced undifferentiated pleomorphic sarcoma: a case report
BackgroundConventional cytotoxic agents and pazopanib are approved for advanced soft tissue sarcomas but have low response rates and modest survival...
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Photon and Proton irradiation in Patient-derived, Three-Dimensional Soft Tissue Sarcoma Models
BackgroundDespite their heterogeneity, the current standard preoperative radiotherapy regimen for localized high-grade soft tissue sarcoma (STS)...
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Bone Sarcoma
While relatively rare, primary bone sarcomas are associated with high morbidity and mortality. A comprehensive history, examination, and imaging...
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Soft Tissue Sarcoma
Soft tissue sarcomas are rare mesenchymal malignancies made up of several heterogeneous subtypes with distinct clinicopathologic features....
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Clinical markers of immunotherapy outcomes in advanced sarcoma
BackgroundDespite immunotherapy’s promise in oncology, its use for sarcoma remains challenging. There are no sarcoma-specific biomarkers for immune...
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Immunotherapy for Sarcoma
Sarcomas represent a rare heterogeneous group of over 80 distinct histological malignancies of mesenchymal origin accounting for 1% of adult...
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Treatment outcomes of stereotactic body radiation therapy for primary and metastatic sarcoma of the spine
PurposeThis study evaluated the treatment outcomes of spine stereotactic body radiation therapy (SBRT) in sarcoma patients.
Materials and methods ...
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Nanoparticle albumin-bound paclitaxel and PD-1 inhibitor (sintilimab) combination therapy for soft tissue sarcoma: a retrospective study
BackgroundThere is increasing evidence that combination therapy with nanoparticle albumin-bound paclitaxel (nab-paclitaxel) and programmed cell death...
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Differentiation of benign and metastatic lymph nodes in soft tissue sarcoma
Lymph node metastasis (LNM) occurs in less than 5% of soft tissue sarcoma (STS) patients and indicates an aggressive course of disease. Suspicious...
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Sarcoma classification by DNA methylation profiling in clinical everyday life: the Charité experience
BackgroundSarcomas are a heterogeneous group of rare malignant tumors with more than 100 subtypes. Accurate diagnosis remains challenging due to a...
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Clinical perspectives and outcomes of the giant breast phyllodes tumor and sarcoma: a real-world retrospective study
BackgroundGiant breast malignant phyllodes tumor or sarcoma (GBPS) are rare entities with diameter larger than 10 cm and variously histological...
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Undifferentiated sarcomatoid carcinoma of the pancreas-a single-institution experience with 23 cases
BackgroundThe clinical course and surgical outcomes of undifferentiated sarcomatoid carcinoma of the pancreas (USCP) remain poorly characterized...
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The Effect of chemo- and radiotherapy on tumor necrosis in soft tissue sarcoma– does it influence prognosis?
BackgroundSoft tissue sarcomas (STSs) are a heterogeneous group of tumors. Wide surgical resection is standard, often combined with neoadjuvant...
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A phase II study of gemcitabine and docetaxel combination in relapsed metastatic or unresectable locally advanced synovial sarcoma
Synovial sarcoma (SS) is one of the commonest non-rhabdomyosarcoma soft tissue sarcoma with limited treatment options in the relapsed and advanced...
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Axitinib in patients with advanced/metastatic soft tissue sarcoma (Axi-STS): an open-label, multicentre, phase II trial in four histological strata
BackgroundAxitinib is an oral vascular endothelial growth factor receptor inhibitor with anti-tumour activity in renal, thyroid, and pancreatic...
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Amputation in patients with extremity soft tissue sarcoma: the experience of an East Asian referral center
BackgroundThis study aimed to investigate the characteristics and clinical outcomes in a series of patients with extremity soft tissue sarcoma (STS)...
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Treatment outcomes of stereotactic body radiation therapy for pulmonary metastasis from sarcoma: a multicenter, retrospective study
PurposeThe aim of this study was to evaluate the treatment outcomes and potential dose-response relationship of stereotactic body radiation therapy...
