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Hemorrhage at high altitude: impact of sustained hypobaric hypoxia on cerebral blood flow, tissue oxygenation, and tolerance to simulated hemorrhage in humans
With ascent to high altitude (HA), compensatory increases in cerebral blood flow and oxygen delivery must occur to preserve cerebral metabolism and...
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Current Status and Progress in Stem Cell Therapy for Intracerebral Hemorrhage
Intracerebral hemorrhage is a highly prevalent and prognostically poor disease, imposing immeasurable harm on human life and health. However, the...
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Ion Channel Dysregulation Following Intracerebral Hemorrhage
Injury to the brain after intracerebral hemorrhage (ICH) results from numerous complex cellular mechanisms. At present, effective therapy for ICH is...
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Clinical Effects of Piracetam Plus Mannitol on Cerebral Edema, Neurological Function, and Vascular Endothelin-1 Levels Following Cerebral Hemorrhage
AbstractThe effects of piracetam plus mannitol on cerebral edema, neurological function, and vascular endothelin-1 (ET-1) levels after cerebral...
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The protective effect of low-dose minocycline on brain microvascular ultrastructure in a rodent model of subarachnoid hemorrhage
The multifaceted nature of subarachnoid hemorrhage (SAH) pathogenesis is poorly understood. To date, no pharmacological agent has been found to be...
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Spontaneous Intracerebral Hemorrhage
Spontaneous, nontraumatic intracerebralHemorrhageintracerebral hemorrhage (ICH) accounts for approximately 10–25% of annual stroke cases and often...
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Effects of New-Generation Antiepileptic Drug Prophylaxis on Delayed Neurovascular Events After Aneurysmal Subarachnoid Hemorrhage
Neuroelectric disruptions such as seizures and cortical spreading depolarization may contribute to the development of delayed cerebral ischemia (DCI)...
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Quantitative Analysis of Stress-Induced Hyperglycemia and Intracranial Blood Volumes for Predicting Mortality After Intracerebral Hemorrhage
Stress-induced hyperglycemia (SIH) is a neuroendocrine response to acute illness. Although SIH has an adverse association with intracerebral...
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Plasma Kallikrein Contributes to Intracerebral Hemorrhage and Hypertension in Stroke-Prone Spontaneously Hypertensive Rats
Plasma kallikrein (PKa) has been implicated in contributing to hemorrhage following thrombolytic therapy; however, its role in spontaneous...
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ANGPT1 methylation and delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage patients
BackgroundDelayed cerebral ischemia (DCI) is a common secondary complication and an important cause of disability and mortality among patients who...
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Type I IFN signaling limits hemorrhage-like disease after infection with Japanese encephalitis virus through modulating a prerequisite infection of CD11b+Ly-6C+ monocytes
BackgroundThe crucial role of type I interferon (IFN-I, IFN-α/β) is well known to control central nervous system (CNS) neuroinflammation caused by...
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Irisin ameliorates neuroinflammation and neuronal apoptosis through integrin αVβ5/AMPK signaling pathway after intracerebral hemorrhage in mice
BackgroundNeuroinflammation is a crucial factor in the development of secondary brain injury after intracerebral hemorrhage (ICH). Irisin is a newly...
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Advances in Therapeutic Approaches for Spontaneous Intracerebral Hemorrhage
Spontaneous intracerebral hemorrhage (ICH) results in high rates of morbidity and mortality, with intraventricular hemorrhage (IVH) being associated...
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Activation of UCP2 by anethole trithione suppresses neuroinflammation after intracerebral hemorrhage
Intracerebral hemorrhage (ICH) is a devastating disease, in which neuroinflammation substantially contributes to brain injury. Uncoupling protein 2...
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Associations between C-reactive protein and white blood cell count, occurrence of delayed cerebral ischemia and poor outcome following aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis
This review and meta-analysis investigated associations of systemic inflammatory marker C-reactive protein (CRP) and white blood cell count (WBC)...
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Biological Effects of Hydrogen Sulfide and Its Protective Role in Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) has extremely high morbidity and mortality, substantially impacting public health. Studying the pathophysiological...
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Characteristics and Outcomes of Anti-interferon Gamma Antibody-Associated Adult Onset Immunodeficiency
PurposeAnti-interferon gamma antibody (AIGA) is a rare cause of adult onset immunodeficiency, leading to severe disseminated opportunistic infections...
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Curcumin Promotes the Expression of IL-35 by Regulating Regulatory T Cell Differentiation and Restrains Uncontrolled Inflammation and Lung Injury in Mice
Interleukin (IL)-35, which has an anti-inflammatory role in acute respiratory distress syndrome (ARDS)/acute lung injury (ALI), is relatively...
