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PCK1 activates oncogenic autophagy via down-regulation Serine phosphorylation of UBAP2L and antagonizes colorectal cancer growth
Phosphoenolpyruvate carboxykinase 1 (PCK1) is the rate-limiting enzyme in gluconeogenesis. PCK1 is considered an anti-oncogene in several human...
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Protein arginine methyltransferases: promising targets for cancer therapy
Protein methylation, a post-translational modification (PTM), is observed in a wide variety of cell types from prokaryotes to eukaryotes. With recent...
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Exploring Ribosomal Genes as Potential Biomarkers of the Immune Microenvironment in Respiratory Syncytial Virus Infection
Respiratory syncytial virus (RSV) is the most common pathogen causing acute lower respiratory tract infection in infants and children. Due to limited...
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Competing Endogenous RNAs Crosstalk in Hippocampus: A Potential Mechanism for Neuronal Develo** Defects in Down Syndrome
Down syndrome (DS) is the most example of aneuploidy, resulting from an additional copy of all or part of chromosome 21. Competing endogenous RNAs...
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Broad proteomics analysis of seeding-induced aggregation of α-synuclein in M83 neurons reveals remodeling of proteostasis mechanisms that might contribute to Parkinson’s disease pathogenesis
Aggregation of misfolded α-synuclein (α-syn) is a key characteristic feature of Parkinson’s disease (PD) and related synucleinopathies. The nature of...
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Proteome profiling of phosphatidylinositol-5-phosphate 4-kinase type 2A and 2B knockdown cells identify modifications in key regulators involved in cell homeostasis and genome integrity
Phosphatidylinositol-5-phosphate 4-kinases (PIP4K) are multiple cellular process regulatory lipid kinases. PIP4K2A and PIP4K2B are overexpressed in...
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Understanding nucleic acid sensing and its therapeutic applications
Nucleic acid sensing is involved in viral infections, immune response-related diseases, and therapeutics. Based on the composition of nucleic acids,...
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The necdin interactome: evaluating the effects of amino acid substitutions and cell stress using proximity-dependent biotinylation (BioID) and mass spectrometry
Prader–Willi syndrome (PWS) is a neurodevelopmental disorder caused by the loss of function of a set of imprinted genes on chromosome 15q11–15q13....
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Comparative analysis of retroviral Gag-host cell interactions: focus on the nuclear interactome
Retroviruses exploit host proteins to assemble and release virions from infected cells. Previously, most studies focused on interacting partners of...
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A review on the role of cyclin dependent kinases in cancers
The Cyclin-dependent kinase (CDK) class of serine/threonine kinases has crucial roles in the regulation of cell cycle transition and is mainly...
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Depletion of UBA protein 2-like protein inhibits growth and induces apoptosis of human colorectal carcinoma cells
Ubiquitin-proteasome system regulates cell proliferation, apoptosis, angiogenesis, and motility, which are processes with particular importance for...
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Differentially expressed genes related to major depressive disorder and antidepressant response: genome-wide gene expression analysis
Treatment response to antidepressants is limited and varies among patients with major depressive disorder (MDD). To discover genes and mechanisms...
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Comprehensive molecular biomarker identification in breast cancer brain metastases
BackgroundBreast cancer brain metastases (BCBM) develop in about 20–30% of breast cancer (BC) patients. BCBM are associated with dismal prognosis not...
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Gender-Specific Expression of Ubiquitin-Specific Peptidase 9 Modulates Tau Expression and Phosphorylation: Possible Implications for Tauopathies
Public transcriptomic studies have shown that several genes display pronounced gender differences in their expression in the human brain, which may...
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Gene Expression Signature in MGUS and Multiple Myeloma
Despite improvement in therapeutic efficacy, multiple myeloma (MM) remains incurable with a median survival of approximately 10 years. Gene...
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Bacillus anthracis’ lethal toxin induces broad transcriptional responses in human peripheral monocytes
BackgroundAnthrax lethal toxin (LT), produced by the Gram-positive bacterium Bacillus anthracis , is a highly effective zinc dependent...
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Identification of novel 17\-estradiol (E2) target genes using cross-experiment gene expression datasets
17β-estradiol (E2) is an environmental estrogen-like chemicals that is known to affect mainly reproductive functions of exposed targets. Although...
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Independent component analysis of Alzheimer's DNA microarray gene expression data
BackgroundGene microarray technology is an effective tool to investigate the simultaneous activity of multiple cellular pathways from hundreds to...
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Molecular Profile of Peripheral Blood Mononuclear Cells from Patients with Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic inflammatory arthritis. Currently, diagnosis of RA may take several weeks, and factors used to predict a poor...
