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PD-1 receptor outside the main paradigm: tumour-intrinsic role and clinical implications for checkpoint blockade
Blocking the inhibitory receptor PD-1 on antitumour T lymphocytes is the main rationale underlying the clinical successes of cancer immunotherapies...
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Tissue inhibitor of matrix metalloproteinase-3 has both anti-metastatic and anti-tumourigenic properties
TIMP-3 is one of four tissue inhibitors of matrix metalloproteinases, the endogenous inhibitors of the matrix metalloproteinase enzymes. These...
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Tumour-associated macrophages and Schwann cells promote perineural invasion via paracrine loop in pancreatic ductal adenocarcinoma
BackgroundPancreatic ductal adenocarcinoma (PDAC) is frequently accompanied by perineural invasion (PNI), which is associated with excruciating...
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From the discovery of helminths to the discovery of their carcinogenic potential
Cancer involves a major aberration in the normal behaviour of cells, making them divide continuously, which interferes with the normal physiology of...
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Inflammation as a shared mechanism of chronic stress related disorders with potential novel therapeutic targets
Stress is a subjective experience that varies across individuals depending on their sensitivity, resilience, and length of exposure to stressors....
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The role of CRAF in cancer progression: from molecular mechanisms to precision therapies
The RAF family of kinases includes key activators of the pro-tumourigenic mitogen-activated protein kinase pathway. Hyperactivation of RAF proteins,...
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Therapeutic potential of inhibiting histone 3 lysine 27 demethylases: a review of the literature
Histone 3 lysine 27 (H3K27) demethylation constitutes an important epigenetic mechanism of gene activation. It is mediated by the Jumonji C...
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Cancer Stem Cell Markers in Haematological Malignancies
Cancer stem cells (CSCs) are a subgroup of tumour cells with tumorigenic potential due to their ability to transform into tumours through...
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Atypical cell cycle regulation promotes mammary stem cell expansion during mammary development and tumourigenesis
BackgroundThe cell cycle of mammary stem cells must be tightly regulated to ensure normal homeostasis of the mammary gland to prevent abnormal...
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A highly predictive autoantibody-based biomarker panel for prognosis in early-stage NSCLC with potential therapeutic implications
BackgroundLung cancer is the leading cause of cancer-related death worldwide. Surgical resection remains the definitive curative treatment for...
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Beta-blocker adjunct therapy as a prospective anti-metastatic with cardio-oncologic regulation
The prevailing treatment stratagem in cancer therapy still challenges the dilemma of a probable metastatic spread following an initial diagnosis....
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Neural Stem Cells and Brain Tumour Models in Drosophila
During development organs and tissues grow in size. This growth can be achieved either by increasing the size of individual cells or by increasing...
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Cancer-associated fibroblast senescence and its relation with tumour-infiltrating lymphocytes and PD-L1 expressions in intrahepatic cholangiocarcinoma
BackgroundCaveolin-1 (CAV1) in cancer-associated fibroblasts (CAFs) has pro- or anti-tumourigenic effect depending on the cancer type. However, its...
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Exploring tumourigenic potential of the parasite Anisakis: a pilot study
Anisakiasis is a global disease caused by consumption of raw or lightly cooked fish parasitised with Anisakis spp. third-stage larvae. Cases in the...
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Getting more bang for their buck: BCL2 inhibitors boost dendritic-cell function to enhance anti-cancer immune surveillance
The anti-apoptotic BCL-2 protein family regulates cancer cell survival, thus it represents an important therapeutic target. Indeed, a drug class,...
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Potential Preventive and Therapeutic Accountability of Probiotics in Cancer: An Insight of Mechanism of Action
Probiotics, the living microorganisms such as bacteria and yeast, are used for the treatment of various disorders like allergies, diarrhoea,...
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High expression of RTEL1 predicates worse progression in gliomas and promotes tumorigenesis through JNK/ELK1 cascade
Gliomas are the most common primary intracranial tumor worldwide. The maintenance of telomeres serves as an important biomarker of some subtypes of...
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The analysis of HPV integration sites based on nanopore sequencing and the profiling changes along the course of photodynamic therapy
ObjectiveTo detect the HPV genotype and integration sites in patients with high-risk HPV infection at different stages of photodynamic therapy using...
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Knock-down of LRP/LR influences signalling pathways in late-stage colorectal carcinoma cells
BackgroundThe 37 kDa/67 kDa laminin receptor (LRP/LR) is involved in several tumourigenic-promoting processes including cellular viability...
