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Inducing expression of ICOS-L by oncolytic adenovirus to enhance tumor-specific bi-specific antibody efficacy
BackgroundIntratumoral injection of oncolytic viruses (OVs) shows promise in immunotherapy: ONCOS-102, a genetically engineered OV that encodes...
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Chromosome evolution screens recapitulate tissue-specific tumor aneuploidy patterns
Whole chromosome and arm-level copy number alterations occur at high frequencies in tumors, but their selective advantages, if any, are poorly...
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Tissue specific tumor-gene link prediction through sampling based GNN using a heterogeneous network
AbstractA tissue sample is a valuable resource for understanding a patient’s symptoms and health status in relation to tumor growth. Recent research...
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An atlas of cell-type-specific interactome networks across 44 human tumor types
BackgroundBiological processes are controlled by groups of genes acting in concert. Investigating gene–gene interactions within different cell types...
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Pan-cancer analysis identifies tumor-specific antigens derived from transposable elements
Cryptic promoters within transposable elements (TEs) can be transcriptionally reactivated in tumors to create new TE-chimeric transcripts, which can...
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HiTIMED: hierarchical tumor immune microenvironment epigenetic deconvolution for accurate cell type resolution in the tumor microenvironment using tumor-type-specific DNA methylation data
BackgroundCellular compositions of solid tumor microenvironments are heterogeneous, varying across patients and tumor types. High-resolution...
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Exploring association of melanoma-specific Bcl-xL with tumor immune microenvironment
BackgroundMacrophages take center stage in the tumor microenvironment, a niche composed of extracellular matrix and a heterogeneous group of cells,...
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Pervasiveness of HLA allele-specific expression loss across tumor types
BackgroundEfficient presentation of mutant peptide fragments by the human leukocyte antigen class I (HLA-I) genes is necessary for immune-mediated...
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The screening, identification, design and clinical application of tumor-specific neoantigens for TCR-T cells
Recent advances in neoantigen research have accelerated the development of tumor immunotherapies, including adoptive cell therapies (ACTs), cancer...
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Definition of a novel breast tumor-specific classifier based on secretome analysis
BackgroundDuring cancer development, the normal tissue microenvironment is shaped by tumorigenic events. Inflammatory mediators and immune cells play...
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Long-term activation of anti-tumor immunity in pancreatic cancer by a p53-expressing telomerase-specific oncolytic adenovirus
BackgroundPancreatic cancer is an aggressive, immunologically “cold” tumor. Oncolytic virotherapy is a promising treatment to overcome this problem....
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Tissue of origin detection for cancer tumor using low-depth cfDNA samples through combination of tumor-specific methylation atlas and genome-wide methylation density in graph convolutional neural networks
BackgroundCell free DNA (cfDNA)-based assays hold great potential in detecting early cancer signals yet determining the tissue-of-origin (TOO) for...
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Analysis of myosin genes in HNSCC and identify MYL1 as a specific poor prognostic biomarker, promotes tumor metastasis and correlates with tumor immune infiltration in HNSCC
Head neck squamous cell carcinoma (HNSCC) is one of the most common malignant tumors which ranks the sixth incidence in the world. Although...
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Tumor extracellular vesicles carrying antitumor (KLAKLAK)2 peptide and tumor-specific antigens for improved tumor therapy
PurposeThis study aimed to fabricate tumor-originated extracellular vesicles (EVs) targeting tumors for use in combination with immunotherapy and...
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In Silico Pipeline to Identify Tumor-Specific Antigens for Cancer Immunotherapy Using Exome Sequencing Data
Tumor-specific antigens or neoantigens are peptides that are expressed only in cancer cells and not in healthy cells. Some of these molecules can...
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Quantifying protrusions as tumor-specific biophysical predictors of cancer invasion in in vitro tumor micro-spheroid models
An important hallmark in cancer research is the discovery of suitable features capable to reliably predict tumor invasiveness, and consequently,...
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The predicting role of serum tumor-specific growth factor for prognosis of esophageal squamous cell carcinoma
ObjectiveTumor-specific growth factor (TSGF) is an immune-related factor that offers good performance in the clinical management of human cancers....
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Tumor lineage-specific immune response in brain metastatic disease: opportunities for targeted immunotherapy regimen?
Metastases in the brain are the most severe and devastating complication of cancer. The incidence of brain metastasis is increasing. Therefore, the...
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Characterization of tumoricidal activities mediated by a novel immune cell regimen composing interferon-producing killer dendritic cells and tumor-specific cytotoxic T lymphocytes
BackgroundAlthough immune cell therapy has long been used for treating solid cancer, its efficacy remains limited. Interferon (IFN)-producing killer...
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Liver-specific lncRNA FAM99A may be a tumor suppressor and promising prognostic biomarker in hepatocellular carcinoma
BackgroundIncreasing evidence shows that liver-specific long non-coding RNAs (lncRNAs) play important roles in the development of hepatocellular...
