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Tumor Heterogeneity in Breast Cancer Progression
Cancer is an aberrant growth of cells with dynamic molecular changes as the disease progresses. As a result of these dynamic changes and an increase...
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Spatial and temporal heterogeneity of tumor immune microenvironment between primary tumor and brain metastases in NSCLC
BackgroundBrain metastasis is a common outcome in non-small cell lung cancer, and despite aggressive treatment, its clinical outcome is still...
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Tumor Heterogeneity in Breast Cancer Progression
Cancer is an aberrant growth of cells with dynamic molecular changes as the disease progresses. As a result of these dynamic changes and an increase...
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The integrate profiling of single-cell and spatial transcriptome RNA-seq reveals tumor heterogeneity, therapeutic targets, and prognostic subtypes in ccRCC
Clear-cell renal cell carcinoma (ccRCC) is the most common type of RCC; however, the intratumoral heterogeneity in ccRCC remains unclear. We first...
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Spatial heterogeneity of tumor microenvironment influences the prognosis of clear cell renal cell carcinoma
BackgroundClear cell renal cell carcinoma (ccRCC) is an immunologically and histologically diverse tumor. However, how the structural heterogeneity...
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Spatial genomic, biochemical and cellular mechanisms underlying meningioma heterogeneity and evolution
Intratumor heterogeneity underlies cancer evolution and treatment resistance, but targetable mechanisms driving intratumor heterogeneity are poorly...
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Decoding the tumor microenvironment with spatial technologies
Visualization of the cellular heterogeneity and spatial architecture of the tumor microenvironment (TME) is becoming increasingly important to...
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From complexity to clarity: unravelling tumor heterogeneity through the lens of tumor microenvironment for innovative cancer therapy
Despite the tremendous clinical successes recorded in the landscape of cancer therapy, tumor heterogeneity remains a formidable challenge to...
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Rapid assessment of 3-dimensional intra-tumor heterogeneity through cycling temperature capillary electrophoresis
ObjectiveTumors are heterogeneous three-dimensional masses populated by numerous cell types, including distinct sub-clones of cancerous cells....
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Metabolic regulation of tumor-associated macrophage heterogeneity: insights into the tumor microenvironment and immunotherapeutic opportunities
Tumor-associated macrophages (TAMs) are a heterogeneous population that play diverse functions in tumors. Their identity is determined not only by...
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Metabolic heterogeneity in clear cell renal cell carcinoma revealed by single-cell RNA sequencing and spatial transcriptomics
BackgroundClear cell renal cell carcinoma is a prototypical tumor characterized by metabolic reprogramming, which extends beyond tumor cells to...
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Single-cell sequencing technology applied to epigenetics for the study of tumor heterogeneity
BackgroundPrevious studies have traditionally attributed the initiation of cancer cells to genetic mutations, considering them as the fundamental...
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Multi-region sequencing with spatial information enables accurate heterogeneity estimation and risk stratification in liver cancer
BackgroundNumerous studies have used multi-region sampling approaches to characterize intra-tumor heterogeneity (ITH) in hepatocellular carcinoma...
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Spatial multi-omics analyses of the tumor immune microenvironment
In the past decade, single-cell technologies have revealed the heterogeneity of the tumor-immune microenvironment at the genomic, transcriptomic, and...
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Dissecting the tumor microenvironment in response to immune checkpoint inhibitors via single-cell and spatial transcriptomics
Cancer is a disease that undergoes selective pressure to evolve during its progression, becoming increasingly heterogeneous. Tumoral heterogeneity...
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Spatial Transcriptomic Approaches for Understanding the Tumor Microenvironment (TME)
The tumor microenvironment (TME) is a heterogeneous milieu of cellular and molecular factors that play a crucial role in tumor evolution and disease...
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Radiogenomic analysis of cellular tumor-stroma heterogeneity as a prognostic predictor in breast cancer
BackgroundThe tumor microenvironment and intercellular communication between solid tumors and the surrounding stroma play crucial roles in cancer...
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Spatial transcriptomics reveals segregation of tumor cell states in glioblastoma and marked immunosuppression within the perinecrotic niche
Glioblastoma (GBM) remains an untreatable malignant tumor with poor patient outcomes, characterized by palisading necrosis and microvascular...
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Non-spatial and spatial heterogeneity revealed a suppressive immune feature of Siglec-15 in lung adenocarcinomas
BackgroundSialic acid-binding immunoglobulin-like lectin-15 (Siglec-15) has emerged as a novel immunotherapy candidate, which deserves a...
