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The interaction of platelet-related factors with tumor cells promotes tumor metastasis
Platelets not only participate in thrombosis and hemostasis but also interact with tumor cells and protect them from mechanical damage caused by...
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Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization
PurposeFor patients with osteosarcoma, disease-related mortality most often results from lung metastasis—a phenomenon shared with many solid tumors....
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Arginase-1 inhibition reduces migration ability and metastatic colonization of colon cancer cells
BackgroundArginase-1 (ARG1), a urea cycle-related enzyme, catalyzes the hydrolysis of arginine to urea and ornithine, which regulates the...
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Noggin contributes to brain metastatic colonization of lung cancer cells
BackgroundBrain metastasis is a common complication among patients with lung cancer, yet the underlying mechanisms remain unclear. In this study, we...
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Novel temporal and spatial patterns of metastatic colonization from breast cancer rapid-autopsy tumor biopsies
BackgroundMetastatic breast cancer is a deadly disease with a low 5-year survival rate. Tracking metastatic spread in living patients is difficult...
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Tumor-secreted exosomal miR-141 activates tumor-stroma interactions and controls premetastatic niche formation in ovarian cancer metastasis
BackgroundMetastatic colonization is one of the critical steps in tumor metastasis. A pre-metastatic niche is required for metastatic colonization...
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AADAC protects colorectal cancer liver colonization from ferroptosis through SLC7A11-dependent inhibition of lipid peroxidation
BackgroundOxidative stress is a highly active metabolic process in the liver, that poses great threats to disseminated tumor cells during their...
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Vancomycin resistant enterococcus risk factors for hospital colonization in hematological patients: a matched case-control study
BackgroundVancomycin-resistant enterococcus (VRE) was the fastest growing pathogen in Europe in 2022 (+ 21%) but its clinical relevance is still...
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Comparison of disease and economic burden between MRSA infection and MRSA colonization in a university hospital: a retrospective data integration study
BackgroundAlthough there is a growing concern and policy regarding infections or colonization caused by resistant bacteria, including...
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Tumor Heterogeneity in Breast Cancer Progression
Cancer is an aberrant growth of cells with dynamic molecular changes as the disease progresses. As a result of these dynamic changes and an increase...
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SCEL regulates switches between pro-survival and apoptosis of the TNF-α/TNFR1/NF-κB/c-FLIP axis to control lung colonization of triple negative breast cancer
BackgroundPatients with metastatic triple-negative breast cancer (mTNBC) have a higher probability of develo** visceral metastasis within 5 years...
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Isolation of Live Immune Cells from the Tumor Microenvironment by FACS
Isolation of live cells from the tumor microenvironment (TME) has represented a challenge, particularly from metastatic nodules that need to be...
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Derivation and validation of a predictive mortality model of in-hospital patients with Acinetobacter baumannii nosocomial infection or colonization
PurposeAcinetobacter baumannii (Ab) is a Gram-negative opportunistic bacterium responsible for nosocomial infections or colonizations. It is...
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Tumor Heterogeneity in Breast Cancer Progression
Cancer is an aberrant growth of cells with dynamic molecular changes as the disease progresses. As a result of these dynamic changes and an increase...
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Tubulointerstitial nephritis antigen-like 1 is a novel matricellular protein that promotes gastric bacterial colonization and gastritis in the setting of Helicobacter pylori infection
The interaction between the gastric epithelium and immune cells plays key roles in H. pylori -associated pathology. Here, we demonstrate a...
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Tumor Microenvironment: Multiway Role in Drug Resistance
The tumor microenvironment (TME) is an ecosystem that surrounds a tumor inside the body. TME contains a complex and dynamic system that consists of...
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Breast Tumor Microenvironment and CDKs
Breast malignancy is one of the most frequently diagnosed carcinoma in women globally, and it is also the common reason for tumor-associated fatality...
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The clustering status of detached gastric cancer cells inhibits anoikis-induced ferroptosis to promote metastatic colonization
Background and purposeFerroptosis is a form of regulated cell death characterized by iron-dependent lipid peroxidation. Its role in cancer metastasis...
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The roles of PD-L1 in the various stages of tumor metastasis
The interaction between tumor programmed death ligand 1 (PD-L1) and T-cell programmed cell death 1 (PD-1) has long been acknowledged as a mechanism...
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3D bioprinted tumor model: a prompt and convenient platform for overcoming immunotherapy resistance by recapitulating the tumor microenvironment
BackgroundCancer immunotherapy is receiving worldwide attention for its induction of an anti-tumor response. However, it has had limited efficacy in...
