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A semi-tryptic peptide centric metaproteomic mining approach and its potential utility in capturing signatures of gut microbial proteolysis
BackgroundProteolysis regulation allows gut microbes to respond rapidly to dynamic intestinal environments by fast degradation of misfolded proteins...
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Human Hepatic Transporter Signature Peptides for Quantitative Targeted Absolute Proteomics: Selection, Digestion Efficiency, and Peptide Stability
PurposeQuantitative targeted absolute proteomics (QTAP) quantifies proteins by measuring the signature peptides produced from target proteins by...
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Peptide Acylation in Aliphatic Polyesters: a Review of Mechanisms and Inhibition Strategies
Biodegradable polyesters are widely employed in the development of controlled release systems for peptide drugs. However, one of the challenges in...
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Dual-function antimicrobial-antibiofilm peptide hybrid to tackle biofilm-forming Staphylococcus epidermidis
BackgroundDue to their resistance and difficulty in treatment, biofilm-associated infections are problematic among hospitalized patients globally and...
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Mass spectrometric profiling of tryptic digests of trifluoroethanol extracts from core needle biopsies of breast cancer tissues is a viable sample screening tool for biomarker discovery
Application of classifying limited sampling biopsies by matrix-assisted laser desorption/ionization time-of-flight (MALDI-ToF) based mass spectral...
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HLA class I signal peptide polymorphism determines the level of CD94/NKG2–HLA-E-mediated regulation of effector cell responses
Human leukocyte antigen (HLA)-E binds epitopes derived from HLA-A, HLA-B, HLA-C and HLA-G signal peptides (SPs) and serves as a ligand for CD94/NKG2A...
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Identification of cerebrospinal fluid biomarkers for parkinsonism using a proteomics approach
The aim of our study was to investigate cerebrospinal fluid (CSF) tryptic peptide profiles as potential diagnostic biomarkers for the discrimination...
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Novel Selective Quantification of Zinpentraxin Alfa Biotherapeutic in the Presence of Endogenous Isomer in Plasma Samples of Idiopathic Pulmonary Fibrosis Patients Using Immunoaffinity LC–MS
Idiopathic pulmonary fibrosis (IPF) is a progressive fatal interstitial lung disease that affects three million patients worldwide and currently...
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Mining for encrypted peptide antibiotics in the human proteome
The emergence of drug-resistant bacteria calls for the discovery of new antibiotics. Yet, for decades, traditional discovery strategies have not...
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Combination antimicrobial therapy: in vitro synergistic effect of anti-staphylococcal drug oxacillin with antimicrobial peptide nisin against Staphylococcus epidermidis clinical isolates and Staphylococcus aureus biofilms
The ability of Staphylococcus epidermidis and S. aureus to form strong biofilm on plastic devices makes them the major pathogens associated with...
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Evaluating the effect of cationic peptide K16ApoE against Staphylococcus epidermidis biofilms
PurposeStaphylococcus epidermidis is one of the most common causative pathogens of nosocomial-related infections. It is known to form biofilms on...
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Using high-abundance proteins as guides for fast and effective peptide/protein identification from human gut metaproteomic data
BackgroundA few recent large efforts significantly expanded the collection of human-associated bacterial genomes, which now contains thousands of...
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Immuno-MALDI-MS for Accurate Quantitation of Targeted Peptides from Volume-Restricted Samples
The immuno-MALDI-MS method can be used to quantify low-abundance proteins from clinical samples that offer only a limited amount of material for...
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Identification of Potential Biomarkers of Porcine Gelatin
This chapter discusses the identification of potential biomarkers of porcine gelatin using peptide mass fingerprinting (PMF) for the development of...
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Mass spectrometric analysis of chondroitin sulfate-linked peptides
Chondroitin sulfate proteoglycans (CSPGs) are extracellular matrix components composed of linear glycosaminoglycan (GAG) side chains attached to a...
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Current Trends in Validating Antibody Specificities for ELISpot by Western Blotting
The enzyme-linked immunospot (ELISpot) assay is a highly useful and sensitive method to detect total immunoglobulin and antigen-specific...
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New approach for the rational selection of markers to identify botulinum toxins
The application of mass spectrometry (MS) to detect unique peptide markers has been widely employed as a means of identifying bacterial proteins....
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Immunomodulatory and Anti-Inflammatory Effects of Vitamin A and Tryptophan on Monocyte-Derived Dendritic Cells Stimulated with Gliadin in Celiac Disease Patients
Celiac Disease (CeD) is an autoimmune disorder with various symptoms upon gluten exposure. Dendritic cells (DCs) play a crucial role in...
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Proteogenomics 101: a primer on database search strategies
Proteogenomics refers to the integration of high-throughput genomics/transcriptomics with proteomics data for genome annotation, novel gene...
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Cell-to-cell transmitted alpha-synuclein recapitulates experimental Parkinson’s disease
Parkinson’s disease is characterized by a progressive accumulation of alpha-Synuclein (αSyn) neuronal inclusions called Lewy bodies in the nervous...
