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The effect of renal impairment and obesity on anti-Xa peak and trough levels in patients receiving therapeutic doses of nadroparin: a comparison with control patients
PurposeAnti-Xa peak level monitoring is recommended during LMWH treatment in renal impairment or obesity. The trough level has been proposed as...
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Decrease of voriconazole trough levels during therapy with enteral nutrition: a case report
BackgroundVoriconazole (VRCZ) is the first-line therapy for chronic pulmonary aspergillosis and is available in both intravenous and oral...
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Ticagrelor Steady-State Trough Concentration in Chinese Patients Undergoing Percutaneous Coronary Intervention
Background and ObjectivePlatelets play a pivotal role in thrombotic events associated with acute coronary syndrome (ACS), making oral antiplatelet...
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Gentamicin Dosing in Neonates with Normal Renal Function: Trough and Peak Levels
Background and ObjectiveGentamicin is commonly used in neonates, and it requires drug concentration monitoring. The objective of this study was to...
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Steady-State Serum IgG Trough Levels Are Adequate for Pharmacokinetic Assessment in Patients with Immunodeficiencies Receiving Subcutaneous Immune Globulin
Patients with primary immunodeficiency diseases often require lifelong immunoglobulin (IG) therapy. Most clinical trials investigating IG therapies...
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Association between tenofovir plasma trough concentrations in the early stage of administration and discontinuation of up to five years tenofovir disoproxil fumarate due to renal function-related adverse events in Japanese HIV-1 infected patients
BackgroundThe relationship between plasma tenofovir (TFV) concentration at the beginning of tenofovir disoproxil fumarate (TDF) administration and...
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Impact of trough abiraterone level on adverse events in patients with prostate cancer treated with abiraterone acetate
PurposeWe assessed the impact of plasma trough concentrations of abiraterone (ABI) and its metabolite Δ4-abiraterone (D4A) and related polymorphisms...
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Serum trough concentration threshold and risk factors of cefoperazone-induced coagulopathy in critically ill patients: A retrospective case-control study
PurposeTo analyze the risk factors influencing the development of cefoperazone-induced coagulopathy in critically ill patients and determine the...
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Safety of linezolid in patients with decreased renal function and trough monitoring: a systematic review and meta-analysis
BackgroundLinezolid causes hematological toxicity, mostly thrombocytopenia, which leads to treatment discontinuation and failure. Recent studies...
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Flucloxacillin decreases tacrolimus blood trough levels: a single-center retrospective cohort study
PurposeTacrolimus and everolimus are widely used to prevent allograft rejection. Both are metabolized by the hepatic cytochrome P450 (CYP) enzyme...
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The impact of ABCB1, CYP3A4/5 and ABCG2 gene polymorphisms on rivaroxaban trough concentrations and bleeding events in patients with non-valvular atrial fibrillation
BackgroundThe influence of genetic factors on the pharmacokinetics and clinical outcomes of rivaroxaban in patients with non-valvular atrial...
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Imatinib pharmacokinetics and creatine kinase levels in chronic myeloid leukemia patients: implications for therapeutic response and monitoring
BackgroundImatinib treatment for certain cancers can lead to elevated creatine kinase (CK) levels, potentially indicating muscle injury, and ongoing...
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Relationship Between Serum Ustekinumab Trough Concentration and Clinical and Biochemical Disease Activity: A Real-World Study in Adult Patients with Crohn’s Disease
Background and ObjectivesThe role of therapeutic drug monitoring for ustekinumab in the treatment of Crohn’s disease has not been defined. This study...
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Switch from a ritonavir to a cobicistat containing antiretroviral regimen and impact on tacrolimus levels in a kidney transplant recipient
BackgroundSolid-organ transplantation due to end-stage organ disease is increasingly performed in people living with HIV. Despite improved transplant...
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Association of Sofosbuvir and Daclatasvir Plasma Trough Concentrations with Patient-, Treatment-, and Disease-Related Factors Among HIV/HCV-Coinfected Persons
BackgroundSofosbuvir plus daclatasvir achieves high rates of sustained virologic response (SVR), with no differences according to HIV serostatus....
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Impacts of pregnane X receptor and cytochrome P450 oxidoreductase gene polymorphisms on trough concentrations of apixaban in patients with non-valvular atrial fibrillation
PurposeWe examined the impact of polymorphisms in genes encoding cytochrome P450 (CYP) 3A5 (gene code CYP3A5 ), P-glycoprotein ( ABCB1 ), breast cancer...
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Propofol modulates neural dynamics of thalamo-cortical system associated with anesthetic levels in rats
The thalamocortical system plays an important role in consciousness. How anesthesia modulates the thalamocortical interactions is not completely...
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Plasma levels of direct oral anticoagulants in atrial fibrillation patients at the time of embolic stroke: a pilot prospective multicenter study
BackgroundPatients with atrial fibrillation (AF) who are on long-term direct oral anticoagulants (DOAC) with low anti-Xa or anti-IIa levels may be at...
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Measuring Emicizumab Levels in the Hemostasis Laboratory
Emicizumab is a bi-specific antibody that in recent years has been introduced in many countries as a prophylactic agent for bleed prevention in cases...