Search
Search Results
-
Reactivation of varicella zoster virus following trigeminal schwannoma resection
Varicella zoster is found exclusively in humans. Infected people with this virus result in chickenpox followed by dormant virus within neural...
-
T-cells in human trigeminal ganglia express canonical tissue-resident memory T-cell markers
BackgroundTrigeminal ganglia (TG) neurons are the main site of lifelong latent herpes simplex virus type 1 (HSV-1) infection. T-cells in ganglia...
-
Varicella-zoster virus proteome-wide T-cell screening demonstrates low prevalence of virus-specific CD8 T-cells in latently infected human trigeminal ganglia
BackgroundTrigeminal ganglia (TG) neurons are an important site of lifelong latent varicella-zoster virus (VZV) infection. Although VZV-specific...
-
The ultrastructure of macaque mesencephalic trigeminal nucleus neurons
Primary afferents originating from the mesencephalic trigeminal nucleus provide the main source of proprioceptive information guiding mastication,...
-
Optogenetic Approach in Trigeminal Neuralgia and Potential Concerns: Preclinical Insights
The integration of optogenetics in the trigeminal pain circuitry broadens and reinforces existing pain investigations. Similar to research on spinal...
-
TET1 Participates in Complete Freund’s Adjuvant-induced Trigeminal Inflammatory Pain by Regulating Kv7.2 in a Mouse Model
Trigeminal inflammatory pain is one of the most severe pain-related disorders in humans; however, the underlying mechanisms remain largely unknown....
-
Early Cerebellar Development in Relation to the Trigeminal System
Despite the wealth of knowledge of adult cerebellar connectivity, little is known about the developmental mechanisms that underpin its development....
-
Prion type 2 selection in sporadic Creutzfeldt–Jakob disease affecting peripheral ganglia
In sporadic Creutzfeldt–Jakob disease (sCJD), the pathological changes appear to be restricted to the central nervous system. Only involvement of the...
-
Expression of CGRP in the Trigeminal Ganglion and Its Effect on the Polarization of Macrophages in Rats with Temporomandibular Arthritis
Calcitonin gene-related peptide (CGRP) is synthesized and secreted by trigeminal ganglion neurons, and is a key neuropeptide involved in pain and...
-
Whole Blood Transcriptome Analysis in Patients with Trigeminal Neuralgia: a Prospective Clinical Study
Trigeminal neuralgia (TN) brings a huge burden to patients, without long-term effective treatment. This study aimed to explore the differentially...
-
Longitudinal alterations of the cisternal segment of trigeminal nerve and brain pain-matrix regions in patients with trigeminal neuralgia before and after treatment
BackgroundTrigeminal neuralgia (TN) is the most common type of chronic neuropathic facial pain, but the etiology and pathophysiological mechanisms...
-
Ultrastructure of dorsal root ganglia
Dorsal root ganglia (DRG) contains thousands of sensory neurons that transmit information about our external and internal environment to the central...
-
Tissue-resident M2 macrophages directly contact primary sensory neurons in the sensory ganglia after nerve injury
BackgroundMacrophages in the peripheral nervous system are key players in the repair of nerve tissue and the development of neuropathic pain due to...
-
α6GABAA Receptor Positive Modulators Alleviate Migraine-like Grimaces in Mice via Compensating GABAergic Deficits in Trigeminal Ganglia
Migraine is caused by hyperactivity of the trigeminovascular system, where trigeminal ganglia (TG) play an important role. This hyperactivity might...
-
Networking brainstem and basal ganglia circuits for movement
The execution and learning of diverse movements involve neuronal networks distributed throughout the nervous system. The brainstem and basal ganglia...
-
Longitudinal transcriptomic characterization of viral genes in HSV-1 infected tree shrew trigeminal ganglia
BackgroundFollowing acute infection, Herpes Simplex virus-1 (HSV-1) establishes lifelong latency and recurrent reactivation in the sensory neurons of...
-
Botulinum Toxin Treatment of Chronic Facial Pain: Trigeminal Neuralgia and Temporo-Mandibular Disorders
Chronic facial pain is physically and emotionally disabling. Trigeminal neuralgia, pain associated with temporomandibular disorders are some of the...
-
N-methyl-D-aspartate Receptor Subunits 2A and 2B Mediate Connexins and Pannexins in the Trigeminal Ganglion Involved in Orofacial Inflammatory Allodynia during Temporomandibular Joint Inflammation
Temporomandibular joint osteoarthritis (TMJOA) is a severe form of temporomandibular joint disorders (TMD), and orofacial inflammatory allodynia is...
-
TLR7 is expressed by support cells, but not sensory neurons, in ganglia
BackgroundToll-like receptor 7 (TLR7) is an innate immune receptor that detects viral single-stranded RNA and triggers the production of...
-
Experience-dependent plasticity in early stations of sensory processing in mature brains: effects of environmental enrichment on dendrite measures in trigeminal nuclei
Nervous systems respond with structural changes to environmental changes even in adulthood. In recent years, experience-dependent structural...
