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Pharmaco-EEG analysis of ligands varying in selectivity for α1 subunit-containing GABAA receptors during the active phase in rats
RationaleBenzodiazepines are known to evoke changes in cortical electrophysiological activity that can be correlated with action at distinct...
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PBPK Analysis to Study the Impact of Genetic Polymorphism of NAT2 on Drug-Drug Interaction Potential of Isoniazid
PurposeIsoniazid (INH) is prescribed both for the prophylaxis as well as the treatment of tuberculosis. It is primarily metabolized through...
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Exploring gender differences in pharmacokinetics of central nervous system related medicines based on a systematic review approach
Due to the inevitable differences in physiological and/or genetic factors between genders, the possibility that differences in pharmacokinetics...
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Induction of CYP3A activity by dexamethasone may not be strong, even at high doses: insights from a case of tacrolimus co-administration
BackgroundDexamethasone (DEX) induces CYP3A activity in a concentration-dependent manner. However, no study has examined changes in the blood...
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Characterization and Applications of Permeabilized Hepatocytes in Drug Discovery
Hepatocytes are one of the most physiologically relevant in vitro liver systems for human translation of clearance and drug-drug interactions (DDI)....
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In Silico Prediction of Pharmacokinetic Profile for Human Oral Drug Candidates Which Lack Clinical Pharmacokinetic Experiment Data
Backgrounds and ObjectivesIn silico methods which can generate high-quality physiologically based pharmacokinetic (PBPK) models for arbitrary drug...
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Management of chronic insomnia using hypnotics: a friend or a foe?
Epidemiological studies suggest that 10–15% adults meet the present criteria for the diagnosis of insomnia disorder; however, there may be...
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Cannabinoid Interactions with Cytochrome P450 Drug Metabolism: a Full-Spectrum Characterization
Medicinal cannabis use has increased exponentially with widespread legalization around the world. Cannabis-based products are being used for numerous...
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Benzodiazepines in Alzheimer’s disease: beneficial or detrimental effects
Dementia is considered a clinical syndrome characterized by cognitive dysfunction and memory loss. Alzheimer's disease (AD) is the most common type...
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Sleep in Space Environment
Sleep deprivation on Earth may impair cognitive performance. As a result, poor mental alertness, attention, and vigilance may lead to fatal...
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Sleep in Space Environment
Sleep deprivation on Earth may impair cognitive performance. As a result, poor mental alertness, attention, and vigilance may lead to fatal...
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Postmortem Toxicology: A Facet of Drugs to Expedite Crimes
Postmortem toxicology is a branch of forensic toxicology that helps in establishing the impact or role of poisonous substances in the death of an...
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Synergistic Herb-Drug Interactions in Neurological Disorders
The incidence of neurological disorders of the brain, spine, and nervous system including Alzheimer’s disease (AD), stroke, dementia, epilepsy, and...
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Serum 4β-hydroxycholesterol increases during fluconazole treatment
PurposeThe antifungal drugs ketoconazole and itraconazole reduce serum concentrations of 4β-hydroxycholesterol, which is a validated marker for...
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Clinical Effects of Piracetam Plus Mannitol on Cerebral Edema, Neurological Function, and Vascular Endothelin-1 Levels Following Cerebral Hemorrhage
AbstractThe effects of piracetam plus mannitol on cerebral edema, neurological function, and vascular endothelin-1 (ET-1) levels after cerebral...
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Sleep During Hypnotic Therapy
Insomnia is a significant public health burden with a prevalence rate of 5–50% in the general population. Evidence indicates that histaminergic,...
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Hypnotics and Sedatives
Sleep is an active physiological process which harmonizes the brain function. A sedative is a drug which reduces activity and alertness by producing...
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Evaluation of Time-Dependent Cytochrome P450 Inhibition Using the Area Under the Curve Shift Method
New molecular entities (NMEs) causing time-dependent inhibition (TDI) of cytochrome P450 (CYP) enzymes are a concern because they can be responsible...
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Pharmacological Management of Insomnia
Insomnia is a highly prevalent condition associated with significant morbidity, reduction in quality of life, and increase in healthcare costs, and...
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The Necessity of Using Changes in Absorption Time to Implicate Intestinal Transporter Involvement in Oral Drug-Drug Interactions
IntroductionIn drug discovery and development, it is of high interest to characterize the potential for intestinal drug-drug interactions to alter...
