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Unveiling the hidden role of disulfidptosis in kidney renal clear cell carcinoma: a prognostic signature for personalized treatment
The role of disulfidptosis in kidney renal clear cell carcinoma (KIRC) remains unknown. This study investigated disulfidptosis-related biomarkers for...
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Multi-omic profiling reveals potential biomarkers of hepatocellular carcinoma prognosis and therapy response among mitochondria-associated cell death genes in the context of 3P medicine
BackgroundCancer cell growth, metastasis, and drug resistance are major challenges in treating liver hepatocellular carcinoma (LIHC). However, the...
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Construction of a prognostic risk score model based on the ARHGAP family to predict the survival of osteosarcoma
BackgroundOsteosarcoma (OS) is the most common primary malignancy of bone tumors. More and more ARHGAP family genes have been confirmed are to the...
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CYP19A1 promotes gastric cancer as part of a lipid metabolism-related gene signature related to the response of immunotherapy and prognosis
BackgroundIncreasing evidence suggests that the metabolism of lipids plays a crucial role in the progression of gastric cancer. However, the...
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Comprehensive Analysis on Prognostic Signature Based on T Cell-Mediated Tumor Killing Related Genes in Gastric Cancer
Although immunotherapy is a valuable treatment for gastric cancer (GC), identifying the patients who would benefit most from this approach presents a...
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Identifying disulfidptosis subtypes in hepatocellular carcinoma through machine learning and preliminary exploration of its connection with immunotherapy
BackgroundHepatocellular carcinoma (HCC) is a highly prevalent and deadly cancer, with limited treatment options for advanced-stage patients....
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Development and validation of a routine blood parameters-based model for screening the occurrence of retinal detachment in high myopia in the context of PPPM
Background/aimsTimely detection and treatment of retinal detachment (RD) could effectively save vision and reduce the risk of progressing visual...
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Noninvasive cardiac radioablation for ventricular tachycardia: dosimetric comparison between linear accelerator- and robotic CyberKnife-based radiosurgery systems
BackgroundFew dosimetric comparisons have been published between linear accelerator (LA)-based systems and CyberKnife (CK)-based robotic radiosurgery...
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Identifying potential signatures for atherosclerosis in the context of predictive, preventive, and personalized medicine using integrative bioinformatics approaches and machine-learning strategies
BackgroundAtherosclerosis is a major contributor to morbidity and mortality worldwide. Although several molecular markers associated with...
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Quantified pathway mutations associate epithelial-mesenchymal transition and immune escape with poor prognosis and immunotherapy resistance of head and neck squamous cell carcinoma
BackgroundPathway mutations have been calculated to predict the poor prognosis and immunotherapy resistance in head and neck squamous cell carcinoma...
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Smooth muscle cell fate decisions decipher a high-resolution heterogeneity within atherosclerosis molecular subtypes
BackgroundMounting evidence has revealed the dynamic variations in the cellular status and phenotype of the smooth muscle cell (SMC) are vital for...
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Spatiotemporal heterogeneity of LMOD1 expression summarizes two modes of cell communication in colorectal cancer
Cellular communication (CC) influences tumor development by mediating intercellular junctions between cells. However, the role and underlying...
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Four distinct trajectories of tau deposition identified in Alzheimer’s disease
Alzheimer’s disease (AD) is characterized by the spread of tau pathology throughout the cerebral cortex. This spreading pattern was thought to be...
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A Computational Platform and Guide for Acceleration of Novel Medicines and Personalized Medicine
In the era of big data and informatics, computational integration of data across the hierarchical structures of human biology enables discovery of...
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Raman spectroscopy detects metabolic signatures of radiation response and hypoxic fluctuations in non-small cell lung cancer
BackgroundRadiation therapy is a standard form of treating non-small cell lung cancer, however, local recurrence is a major issue with this type of...
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Analysis of prognosis, genome, microbiome, and microbial metabolome in different sites of colorectal cancer
BackgroundThe colorectum includes ascending colon, transverse colon, descending colon, sigmoid colon, and rectum. Different sites of colorectal...
