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Plasmodium falciparum: Transporter and Drug Target
Malaria will continue to be a concern for public health well into the future, as it is responsible for more than 50 million fatalities annually...
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Discovery and Development of Monoamine Transporter Ligands
Monoamine transporters (MATs) are targets of a wide range of compounds that have been developed as therapeutic treatments for various...
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Glutathione transporter as a target for brain drug delivery
Inability to achieve therapeutic concentrations of a medication in the brain due to the blood brain barrier (BBB) is the major cause of treatment...
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The glucose transporter GLUT12, a new actor in obesity and cancer
Obesity constitutes a global health epidemic which worsens the main leading death causes such as type 2 diabetes, cardiovascular diseases, and...
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Dyshomeostasis of Iron and Its Transporter Proteins in Cypermethrin-Induced Parkinson’s Disease
The etiology of Parkinson’s disease (PD) is highly complex and is still indefinable. However, a number of studies have indicated the involvement of...
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Impact of 1α,25-dihydroxyvitamin D3 on biodistribution and pharmacokinetics of L-carnitine and creatinine, organic cation/carnitine transporter 2 and organic cation transporter 2 biomarkers
PurposeThis study investigated effects of 1α,25-dihydroxyvitamin D 3 [1,25(OH) 2 D 3 ] on biodistribution and pharmacokinetics of L-carnitine and...
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Knockout Transporter Cell Lines to Assess Substrate Potential Towards Efflux Transporters
P-glycoprotein (P-gp), breast cancer resistance protein (BCRP) and multidrug resistance transporter 2 (MRP2) are efflux transporters involved in the...
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Mechanistic Static Model based Prediction of Transporter Substrate Drug-Drug Interactions Utilizing Atorvastatin and Rifampicin
ObjectiveAn in vitro relative activity factor (RAF) technique combined with mechanistic static modeling was examined to predict drug-drug...
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The Endolysosomal Transporter DMT1 is Required for Morphine Regulation of Neuronal Ferritin Heavy Chain
NeuroHIV and other neurologic disorders present with altered iron metabolism in central nervous system neurons. Many people with HIV also use...
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Understanding adefovir pharmacokinetics as a component of a transporter phenoty** cocktail
PurposeAdefovir (as dipivoxil) was selected as a probe drug in a previous transporter cocktail phenoty** study to assess renal organic anion...
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Seasonal patterns in microbial carbon and iron transporter expression in the Southern Ocean
BackgroundHeterotrophic microbes in the Southern Ocean are challenged by the double constraint of low concentrations of organic carbon (C) and iron...
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GHB toxicokinetics and renal monocarboxylate transporter expression are influenced by the estrus cycle in rats
BackgroundThe illicit use and abuse of gamma-hydroxybutyric acid (GHB) occurs due to its sedative/hypnotic and euphoric effects. Currently, there are...
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Astrocyte Glutamate Transporter EAAT2 in Alzheimer Dementia
Glutamate is an amino acid and also the major synaptic signaling molecule of neurons, essential in cognition, learning, and memory. Glutamate is...
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Somatic SLC30A1 mutations altering zinc transporter ZnT1 cause aldosterone-producing adenomas and primary aldosteronism
Primary aldosteronism (PA) is the most common form of endocrine hypertension and is characterized by inappropriately elevated aldosterone production...
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Vitamin C transporter SVCT1 serves a physiological role as a urate importer: functional analyses and in vivo investigations
Uric acid, the end product of purine metabolism in humans, is crucial because of its anti-oxidant activity and a causal relationship with...
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Interaction of the chemotherapeutic agent oxaliplatin and the tyrosine kinase inhibitor dasatinib with the organic cation transporter 2
Oxaliplatin (OHP) is effective in colorectal cancer treatment but induces peripheral neurotoxicity (OHP-induced peripheral neurotoxicity, OIPN),...
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Utilization of Rosuvastatin and Endogenous Biomarkers in Evaluating the Impact of Ritlecitinib on BCRP, OATP1B1, and OAT3 Transporter Activity
PurposeRitlecitinib, an inhibitor of Janus kinase 3 and tyrosine kinase expressed in hepatocellular carcinoma family kinases, is in development for...
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Substantia nigral dopamine transporter uptake in dementia with Lewy bodies
Nigrostriatal dopaminergic degeneration is a pathological hallmark of dementia with Lewy bodies (DLB). To identify the subregional dopamine...
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Kinetic profiling of novel spirobenzo-oxazinepiperidinone derivatives as equilibrative nucleoside transporter 1 inhibitors
Evaluation of kinetic parameters of drug-target binding, k on , k off , and residence time (RT), in addition to the traditional in vitro parameter of...
