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Contribution of Transglutaminase to the Induction and Maintenance of Long-Term Synaptic Potentiation in Neurons in the Common Snail
Previous studies have shown that the neurotransmitter serotonin is required for the successful formation of long-term potentiation in the terrestrial...
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The Complete Genomic Sequence of Microbial Transglutaminase Producer, Streptomyces mobaraensis DSM40587
Actinomycetes are remarkable natural sources of active natural molecules and enzymes of considerable industrial value. Streptomyces mobaraensis is...
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Expression of transglutaminase-2 (TGM2) in the prognosis of female invasive breast cancer
BackgroundTransglutaminase 2 (TGM2) is a protein expressed in several isoforms in both intra- and extra-cellular tissue compartments. It has multiple...
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Transglutaminase 2 is associated with adverse colorectal cancer survival and represents a therapeutic target
Molecular markers for predicting prognosis of colorectal cancer (CRC) patients are urgently needed for effective disease management. We reported...
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Transcriptomic analysis of intestine following administration of a transglutaminase 2 inhibitor to prevent gluten-induced intestinal damage in celiac disease
Transglutaminase 2 (TG2) plays a pivotal role in the pathogenesis of celiac disease (CeD) by deamidating dietary gluten peptides, which facilitates...
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Transglutaminase-2 mediates acquisition of neratinib resistance in metastatic breast cancer
Acquisition of resistance to targeted therapies remains a major clinical obstacle for the HER2 + subtype of breast cancer. Using an isogeneic...
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Transglutaminase 3 suppresses proliferation and cisplatin resistance of cervical cancer cells by inactivation of the PI3K/AKT pathway
Recent studies have shown that dysregulation of transglutaminase 3 (TGM3) is related to the aggressive progression of several cancer types. Our study...
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Circulating anti-hypothalamus antibodies in celiac patients: tissue transglutaminase friend or foe?
Celiac disease (CD) is an autoimmune disease with inflammatory characteristics, having a condition of chronic malabsorption, affecting approximately...
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Histological confinement of transglutaminase-mediated nit sheath crosslinking is essential for proper oviposition and egg coating in the human head louse, Pediculus humanus capitis
BackgroundHead louse females secrete liquid gel, which is mainly composed of the louse nit sheath protein 1 (LNSP1) and LNSP2, when they lay eggs....
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Transglutaminase-Mediated Conjugations
Microbial transglutaminase (MTGase) catalyzes site-specific transpeptidation between a primary amine within linkers and the side chain of glutamine...
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Nuclear Transglutaminase 2 interacts with topoisomerase II⍺ to promote DNA damage repair in lung cancer cells
BackgroundTo block repairs of DNA damages, especially the DNA double strand break (DSB) repair, can be used to induce cancer cell death. DSB repair...
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Contribution of Epigenetic Mechanisms to the Formation, Maintenance, and Reconsolidation of a Long-Term Food-Related Aversive Memory in Terrestrial Snails
The study reported here analyzed the role of epigenetic mechanisms (histone acetylation, DNA methylation, and histone serotonylation) in the...
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Characterization of nit sheath protein functions and transglutaminase-mediated cross-linking in the human head louse, Pediculus humanus capitis
BackgroundHead louse females secrete liquid glue during oviposition, which is solidified to form the nit sheath over the egg. Recently, two...
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Transglutaminase 2 crosslinks the glutathione S-transferase tag, impeding protein–protein interactions of the fused protein
Glutathione S-transferase (GST) from Schistosoma japonicum has been widely used as a tag for affinity purification and pulldown of fusion proteins to...
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Amplification of transglutaminase 2 enhances tumor-promoting inflammation in gastric cancers
Tumor-promoting inflammation is a hallmark of cancer and is highly associated with tumor progression, angiogenesis, and metastasis. Tumor-associated...
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Neurite outgrowth inhibitory levels of organophosphates induce tissue transglutaminase activity in differentiating N2a cells: evidence for covalent adduct formation
Organophosphate compounds (OPs) induce both acute and delayed neurotoxic effects, the latter of which is believed to involve their interaction with...
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Assessment of autoantibodies in paediatric population with primary immunodeficiencies: a pilot study
BackgroundThe correlation between primary immunodeficiencies (PIDs) and autoimmunity shows ethnic and geographical diversity. The aim of our study...
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Coeliac Disease in Children and Young Adults
Coeliac disease (CD) is an autoimmune disorder that occurs in genetically predisposed individuals who develop an immune reaction to gluten. The...
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Hexahydrocurcumin attenuated demyelination and improved cognitive impairment in chronic cerebral hypoperfusion rats
Age-related white matter lesions (WML) frequently present vascular problems by decreasing cerebral blood supply, resulting in the condition known as...
