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The Role of Exosomes in Tumor Metastasis
Exosomes, extracellular vesicles featuring phospholipid bilayers, play essential roles in cell–cell communication; tumor microenvironment (TME)...
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Invasion and Metastasis
This chapter delineates processes, molecules, and interactions contributing to invasion and metastasis, the most defining properties of malignancy....
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Tumor microenvironment in ovarian cancer peritoneal metastasis
Ovarian cancer (OC) is one of the most common gynecological malignancies with high morbidity and mortality. The peritoneum is one of the most common...
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Hsa_circ_0000497 and hsa_circ_0000918 contributed to peritoneal metastasis of ovarian cancer via ascites
PurposeAs a common complication of epithelial ovarian cancer (EOC), malignant ascites contributes to the peritoneal metastasis of EOC. CircRNAs play...
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Biology, Chemistry, and Physics of Cancer Cell Motility and Metastasis
A malignant tumor has ability to invade the nearby tissues and colonize distant sites (organs) through the lymphatic/vascular system. From...
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Nanotechnology-aided advancement in the combating of cancer metastasis
Cancer, especially when it has metastasized to different locations in the body, is notoriously difficult to treat. Metastatic cancer accounts for...
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Current insights into the metastasis of epithelial ovarian cancer - hopes and hurdles
BackgroundOvarian cancer is the most lethal gynecologic cancer and the fifth leading cause of cancer-related mortality in women worldwide. Despite...
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Tumor-secreted exosomal miR-141 activates tumor-stroma interactions and controls premetastatic niche formation in ovarian cancer metastasis
BackgroundMetastatic colonization is one of the critical steps in tumor metastasis. A pre-metastatic niche is required for metastatic colonization...
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Molecular mediators of peritoneal metastasis in pancreatic cancer
Pancreatic cancer is the third leading cause of cancer death in the USA, and pancreatic ductal adenocarcinoma (PDA) constitutes 85% of pancreatic...
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Gemcitabine induces polarization of mouse peritoneal macrophages towards M1-like and confers antitumor property by inducing ROS production
AbstractIn patients with pancreatic cancer (PC), the peritoneal cavity is the second-most common site of metastasis after the liver. Peritoneal...
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HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling
BackgroundPeritoneal metastasis, which accounts for 85% of all epithelial ovarian carcinoma (EOC) metastases, is a multistep process that requires...
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Gene signature characteristic of elevated stromal infiltration and activation is associated with increased risk of hematogenous and lymphatic metastasis in serous ovarian cancer
BackgroundThe clinical significance of hematogenous and lymphatic metastasis in ovarian cancer has been increasingly addressed, as it plays an...
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The metastatic capacity of high-grade serous ovarian cancer cells changes along disease progression: inhibition by mifepristone
BackgroundSimplistic two-dimensional (2D) in vitro assays have long been the standard for studying the metastatic abilities of cancer cells. However,...
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Cancer Stem Cells: An Ever-Hiding Foe
Cancer stem cells are a population of cells enable to reproduce the original phenotype of the tumor and capable to self-renewal, which is crucial for...
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The untapped potential of ascites in ovarian cancer research and treatment
The build-up of fluid in the peritoneal cavity—ascites—is a hallmark of ovarian cancer, the most lethal of all gynaecological malignancies. This...
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TGFβ signaling networks in ovarian cancer progression and plasticity
Epithelial ovarian cancer (EOC) is a leading cause of cancer-related death in women. Late-stage diagnosis with significant tumor burden, accompanied...
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The Many Microenvironments of Ovarian Cancer
High-grade serous ovarian cancer (HGSOC) is the most common and deadly subtype of ovarian cancer as it is commonly diagnosed after substantial...
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Angiotensin II promotes ovarian cancer spheroid formation and metastasis by upregulation of lipid desaturation and suppression of endoplasmic reticulum stress
BackgroundAngiotensin II (ANGII) and its receptor (AGTR1) have been proposed as significant contributors to metastasis in multiple cancers. Further,...
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Toll-like receptors: exploring their potential connection with post-operative infectious complications and cancer recurrence
Cancer is the leading cause of death in North America. Despite modern advances in cancer therapy, many patients will ultimately develop cancer...
