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Is tranexamic acid safe for the hip joint?
To show the effects of tranexamic acid, which is a drug frequently used to control bleeding, on the hip joint and sciatic nerve in animal...
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The effect of tranexamic acid on synovium of patients undergoing arthroplasty and anterior cruciate ligament reconstruction surgery
Preoperative hemorrhage can be reduced using anti-fibrinolytic medicine tranexamic acid (TXA). During surgical procedures, local administration is...
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Tranexamic acid administered intraarticularly to the knee is safer for the articular cartilage and anterior cruciate ligament compared to intravenous administration: Histological analysis of an experimental rat model
In this study, the effects of tranexamic acid (TXA) on the knee’s articular cartilage, anterior cruciate ligament (ACL), and joint capsule were...
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Renal ischemic adverse drug events related to tranexamic acid in women of child-bearing age: an analysis of pharmacovigilance data
PurposeIn response to a large trial, the World Health Organization broadened their recommendation on tranexamic acid to be used for post-partum...
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Nasal Powder Formulation of Tranexamic Acid and Hyaluronic Acid for the Treatment of Epistaxis
PurposeThe aim of this study was to develop a nasal powder formulation of the antifibrinolytic drug, tranexamic acid (TXA), in combination with the...
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Biomarkers in Neurological Injury: Fibrinogen, Fibrinogen/Fibrin Degradation Products (FDPs), and D-dimer
Fibrinogen, fibrinogen/fibrin degradation products (FDPs), and D-dimer are important factors in neurological injury and its sequelae. When the...
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Effect of tranexamic acid in improving the lifespan of naturally aging mice
An effective method to improve lifespan is not known. Therefore, in this study, we examined the lifespan-extending effect of tranexamic acid in...
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Tranexamic acid attenuates inflammatory effect and modulates immune response in primary total knee arthroplasty: a randomized, placebo-controlled, pilot trial
AimsTo explore the effect of intravenous tranexamic acid (IV-TXA) on inflammation and immune response following primary total knee arthroplasty (TKA).
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Biomarkers in Neurological Injury: Fibrinogen, Fibrinogen/Fibrin Degradation Products (FDPs), and D-dimer
Fibrinogen, fibrinogen/fibrin degradation products (FDPs), and D-dimer are important factors in neurological injury and its sequelae. When the...
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Micromechanical Force Measurement of Clotted Blood Particle Cohesion: Understanding Thromboembolic Aggregation Mechanisms
PurposeArterial shear forces may promote the embolization of clotted blood from the surface of thrombi, displacing particles that may occlude...
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Tranexamic acid reduces heme cytotoxicity via the TLR4/TNF axis and ameliorates functional recovery after spinal cord injury
BackgroundSpinal cord injury (SCI) is a catastrophic trauma accompanied by intralesional bleeding and neuroinflammation. Recently, there is...
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Application of a Thermosensitive In Situ Gel of Chitosan-Based Nasal Spray Loaded with Tranexamic Acid for Localised Treatment of Nasal Wounds
The integrity of the nasal epithelium plays a crucial role in the airway defence mechanism. The nasal epithelium may be injured as a result of a...
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Predictors and Outcomes of Neurological Deterioration in Intracerebral Hemorrhage: Results from the TICH-2 Randomized Controlled Trial
Neurological deterioration is common after intracerebral hemorrhage (ICH). We aimed to identify the predictors and effects of neurological...
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A cost-effectiveness analysis of early detection and bundled treatment of postpartum hemorrhage alongside the E-MOTIVE trial
Timely detection and treatment of postpartum hemorrhage (PPH) are crucial to prevent complications or death. A calibrated blood-collection drape can...
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Dynamics of Collagen Synthesis after Liver Trauma in in vivo Experiments
The results of a comparative study of the dynamics of serum hydroxyproline levels in laboratory animals after liver injury during laparoscopy and the...
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Laser-mediated Solutions: Breaking Barriers in Transdermal Drug Delivery
Skin diseases pose challenges in treatment due to the skin’s complex structure and protective functions. Topical drug delivery has emerged as a...
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The Quantra System: System Description and Protocols for Measurements
Over the past two decades, the TEG 5000 (Haemonetics Corp, Braintree, MA) and ROTEM delta (Werfen, Bedford, MA) have been the principal viscoelastic...
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Modified Rotational Thromboelastometry Protocol Using Tissue Plasminogen Activator for Detection of Hypofibrinolysis and Hyperfibrinolysis
Viscoelastic testing includes thromboelastography (TEG®) and thromboelastometry (ROTEM®) and is widely used in bleeding patients to detect...