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Clinical outcomes and treatment necessity in patients with toxin-negative Clostridioides difficile stool samples
PurposeThe clinical significance of negative toxin enzyme immunoassays (EIA) for Clostridioides difficile infections (CDIs) is unclear. Our study...
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Diagnostic Guidance for C. difficile Infections
Diagnosis of Clostridioides difficile infection (CDI) can be challenging. First of all, there has been debate on which of the two reference assays,...
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Predictive value of fecal calprotectin and lactoferrin levels for negative outcomes in Clostridioides difficile infection
PurposeWe investigated the role of fecal calprotectin (FC) and lactoferrin (FL) as predictive biomarkers in Clostridioides difficile infection (CDI).
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Ribotypes and New Virulent Strains Across Europe
Clostridioides (formerly Clostridium) difficile is a major bacterial cause of post-antibiotic diarrhoea. The epidemiology of C. difficile infections...
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Evaluation of a two step testing algorithm to improve diagnostic accuracy and stewardship of Clostridioides difficile infections
In response to national guidelines, we implemented a two-step testing algorithm for Clostridioides difficile in an effort to improve diagnostic...
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Simultaneous detection and riboty** of Clostridioides difficile, and toxin gene detection directly on fecal samples
BackgroundClostridioides difficile is the most common cause of nosocomial diarrhea. Riboty** of cultured strains by a PCR-based test is used to...
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Clostridioides difficile
C. difficile is a gram-positive, anaerobic spore-forming bacterium considered as the leading cause of antibiotic-associated diarrhea and...
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Gut metabolites predict Clostridioides difficile recurrence
BackgroundClostridioides difficile infection (CDI) is the most common hospital acquired infection in the USA, with recurrence rates > 15%. Although...
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Recurrent Clostridioides difficile Infection: Current Clinical Management and Microbiome-Based Therapies
Clostridioides difficile is one of the most important causes of healthcare-associated diarrhea. The high incidence and recurrence rates of C. difficile ...
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Implementing a Clostridium difficile testing algorithm and its effect on isolation duration and treatment initiation: a pre- and post-implementation study
A proportion of patients suspected of Clostridium difficile infection are unnecessarily placed in contact isolation. By introducing a random-access...
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Predictive factors, outcomes, and molecular epidemiology of Clostridioides difficile diarrhea in Brazilian hospitals
Little is known about the role of lineage of strains of Clostridioides difficile (CD) on the clinical presentation of CD infection (CDI) in Latin...
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Prevalence and molecular subty** of Blastocystis in patients with Clostridium difficile infection, Singapore
BackgroundBlastocystis is a common anaerobic colonic protist in humans with controversial pathogenicity. Clostridium difficile ( C. difficile ) is the...
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A 2-step algorithm combining glutamate dehydrogenase and nucleic acid amplification tests for the detection of Clostridioides difficile in stool specimens
The optimized diagnosis algorithm of Clostridioides difficile infection (CDI) is worldwide concerns. The purpose of this study was to assess the...
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Longitudinal genomic surveillance of carriage and transmission of Clostridioides difficile in an intensive care unit
Despite enhanced infection prevention efforts, Clostridioides difficile remains the leading cause of healthcare-associated infections in the United...
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Epidemiology of gastrointestinal infections: lessons learned from syndromic testing, Region Zealand, Denmark
The aim of this study was to investigate the value of syndromic diagnostic testing for a better understanding of the epidemiology of gastrointestinal...
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Can a toxin gene NAAT be used to predict toxin EIA and the severity of Clostridium difficile infection?
BackgroundDiagnosis of C. difficile infection (CDI) is controversial because of the many laboratory methods available and their lack of ability to...
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Impact of ribotype on Clostridioides difficile diagnostics
This study investigates the performance of diagnostic methods for detection of Clostridioides difficile infection in Sweden, including impact of PCR...
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Clostridium difficile infection: review
Clostridium difficile ( C. difficile ) is a Gram-positive, spore-forming, anaerobic bacillus, which is widely distributed in the intestinal tract of...
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Fecal calprotectin concentrations in cancer patients with Clostridium difficile infection
Fecal calprotectin (fCPT) has been used as a surrogate marker for assessment of intestinal inflammation. We explore the utility of fCPT values as a...
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Clinical heterogeneity of patients with stool samples testing PCR+/Tox− from a two-step Clostridium difficile diagnostic algorithm
The clinical significance of indeterminate (PCR+/Tox−) results for patients tested with a two-step algorithm for Clostridium difficile infection...
