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Acetylcholinesterase inhibition in electric eel and human donor blood: an in vitro approach to investigate interspecies differences and human variability in toxicodynamics
In chemical risk assessment, default uncertainty factors are used to account for interspecies and interindividual differences, and differences in...
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PBTK modeling of the pyrrolizidine alkaloid retrorsine to predict liver toxicity in mouse and rat
Retrorsine is a hepatotoxic pyrrolizidine alkaloid (PA) found in herbal supplements and medicines, food and livestock feed. Dose-response studies...
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Toxicokinetic of Xenobiotics
Toxicokinetics, which is analogous to pharmacokinetics, is the study of the absorption, distribution, metabolism, and excretion of a xenobiotic under...
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Erythrocyte Acetylcholinesterase as a Biomarker of Environmental Lead Exposure
Lead is a prime, ubiquitous, environmental toxicant and multi-organ poison. One of the most recognized deleterious effects of lead exposure is...
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Toxicokinetic Tests
Toxicokinetics is an integral component of toxicological studies in order to interrelate the administered dose with the associated effect....
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Toxicokinetic Tests
Toxicokinetics is an integral component of toxicological studies in order to interrelate the administered dose with the associated effect....
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Erythrocyte Acetylcholinesterase as a Biomarker of Environmental Lead Exposure
Lead is a prime, ubiquitous, environmental toxicant and multi-organ poison. One of the most recognized deleterious effects of lead exposure is...
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Checklist: Toxicological Risk Assessment in Practice
The checklist gives brief practical hints for all those who are occasionally or professionally involved in toxicological risk assessment, risk...
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Checklist: Toxicological Risk Assessment in Practice
The checklist gives brief practical hints for all those who are occasionally or professionally involved in toxicological risk assessment, risk...
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Defence of Biocidal Active Substance Dossiers in the Context of Regulatory Toxicology
In this chapter, the expertise gathered in the broad area of toxicology and its implementation into the regulatory context is illustrated using the...
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Defence of Biocidal Active Substance Dossiers in the Context of Regulatory Toxicology
In this chapter, the expertise gathered in the broad area of toxicology and its implementation into the regulatory context is illustrated using the...
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Toxicological inhalation studies in rats to substantiate grou** of zinc oxide nanoforms
BackgroundSignificant variations exist in the forms of ZnO, making it impossible to test all forms in in vivo inhalation studies. Hence, grou** and...
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Neurotoxic Electrophile Interactions with Brain Selenoenzymes
The physiological effects of selenium (Se) occur through the biochemical actions of selenocysteine (Sec), the twenty-first genetically encoded amino...
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Cytochrome P450: In Vitro Methods and Protocols
Chapter provides background information useful in fully understanding how and why cytochrome P450 (CYP) in vitro methods and protocols are important...
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Neurotoxic Electrophile Interactions with Brain Selenoenzymes
The physiological effects of selenium (Se) occur through the biochemical actions of selenocysteine (Sec), the twenty-first genetically encoded amino...
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General Toxicology
Modern toxicology is a science-based toxicology; the scope and future of toxicologists are very bright because this branch of science will further...
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Nanotoxicity and Risk Assessment of Nanomedicines
Nanotechnological advances have significantly boosted the quality of human life. However, the underlying risks associated with the engineered...
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In Silico Methods for Environmental Risk Assessment: Principles, Tiered Approaches, Applications, and Future Perspectives
This chapter aims to introduce the reader to the basic principles of environmental risk assessment of chemicals and highlights the usefulness of...
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General Principles of Toxicology
This chapter deals with the general principles and emergence of science-based toxicology and the scope and current status of veterinary toxicology....