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A Methodological Workflow to Analyze Synthetic Lethality and Drug Synergism in Cancer Cells
Current concepts in treating cancer usually neglect individual tumor characteristics such as a given mutational make up. Consequently, a...
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Gallium maltolate shows synergism with cisplatin and activates nucleolar stress and ferroptosis in human breast carcinoma cells
PurposeBreast cancer is the most common cancer in women. Triple-negative breast cancer (TNBC) is an aggressive disease with poor outcomes. TNBC lacks...
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Do combinations of fipronil, eugenol and carvacrol have synergistic effects against Rhipicephalus sanguineus?
The tick Rhipicephalus sanguineus is one of the main ectoparasites that affects dogs, causing direct and indirect damage to parasitized animals....
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High-Throughput Measurement for Toxic Effects of Metal Mixtures in Caenorhabditis elegans
The contamination of heavy metals, a class of naturally occurring and persistent toxicants, has become a major public health concern due to...
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Lipid-based nanoparticle-mediated combination therapy for breast cancer management: a comprehensive review
Breast cancer due to the unpredictable and complex etiopathology combined with the non-availability of any effective drug treatment has become the...
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Anti-lung cancer synergy of low-dose doxorubicin and PD-L1 blocker co-delivered via mild photothermia-responsive black phosphorus
We have previously identified a latent interaction mechanism between non-small cell lung cancer cells (NSCLCC) and their associated macrophages (TAM)...
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Synergistic toxicity with copper contributes to NAT2-associated isoniazid toxicity
Anti-tuberculosis (AT) medications, including isoniazid (INH), can cause drug-induced liver injury (DILI), but the underlying mechanism remains...
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Molecular and functional profiling of chemotolerant cells unveils nucleoside metabolism-dependent vulnerabilities in medulloblastoma
Chemotherapy resistance is considered one of the main causes of tumor relapse, still challenging researchers for the identification of the molecular...
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Genistein: a promising modulator of apoptosis and survival signaling in cancer
Genistein, a commonly occurring isoflavone, has recently gained popularity owing to its ever-expanding spectrum of pharmacological benefits. In...
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Forensic Toxicology: An Overview
Forensic Toxicology is a branch of Forensic Science that involves the application of various scientific principles, methods and techniques to aid in...
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Oxidative stress induction by narasin augments doxorubicin’s efficacy in osteosarcoma
Complications and fata toxicity induced by chemotherapy are the main challenge for clinical management of osteosarcoma. The identification of agents...
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The Determination of Cisplatin and Luteolin Synergistic Effect on Colorectal Cancer Cell Apoptosis and Mitochondrial Dysfunction by Fluorescence Labelling
Despite the initial success of chemotherapy in the treatment of colorectal carcinoma (CRC), the recurrence of the disease shows that the tumor...
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Basal release of 6-cyanodopamine from rat isolated vas deferens and its role on the tissue contractility
6-Cyanodopamine is a novel catecholamine released from rabbit isolated heart. However, it is not known whether this catecholamine presents any...
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The effects of co-exposure to methyl paraben and dibutyl phthalate on cell line derived from human skin
Data on the cumulative effects of chemical substances are necessary for the proper risk assessment, but their availability is still insufficient. The...
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Neurotoxic Cyanobacterial Toxins
Cyanobacteria (commonly referred to as blue green algae) can produce over 100 known toxins (cyanotoxins). In this chapter, cyanotoxins with...
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Versatile Structurally Diverse Natural Products and Their Semisynthetic Analogs as Potential Antileishmanial Drugs
Mortalities associated with leishmaniasis are skyrocketing at an alarming rate. Lack of vaccine for leishmaniasis treatment is making the fight...
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Neurotoxic Cyanobacterial Toxins
Cyanobacteria (commonly referred to as blue green algae) can produce over 100 known toxins (cyanotoxins). In this chapter, cyanotoxins with...
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Computational Modeling of Mixture Toxicity
Environmental pollution has become an inevitable problem and a relevant global issue of the twenty-first century. The fast industrial growth has...
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Cardenolide glycosides sensitize gefitinib-induced apoptosis in non-small cell lung cancer: inhibition of Na+/K+-ATPase serving as a switch-on mechanism
The treatment of non-small cell lung cancer (NSCLC) is known as a significant level of unmet medical need in spite of the progress in targeted...
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Environmental Toxicology
Environmental toxicology investigates the adverse effects caused by natural and synthetic pollutants in all living organisms of ecosystems and at all...