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The 60-year evolution of lipid nanoparticles for nucleic acid delivery
Delivery of genetic information to the interior of target cells in vivo has been a major challenge facing gene therapies. This barrier is now being...
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Introduction to Online Nucleic Acid Databases for EV Research
Extracellular vesicles (EVs), a type of lipid membrane-coated vesicles, contain proteins, DNA, RNAs, and lipids and are categorized into three main...
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Targeting strategies with lipid vectors for nucleic acid supplementation therapy in Fabry disease: a systematic review
Fabry disease (FD) results from a lack of activity of the lysosomal enzyme α-Galactosidase A (α-Gal A), leading to the accumulation of...
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Assessing the comparability of cycle threshold values derived from five external quality assessment rounds for omicron nucleic acid testing
BackgroundA variety of open-system real-time reverse transcriptase polymerase chain reaction (RT-PCR) assays for several acute respiratory syndrome...
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Plasmonic Nanoparticle Conjugation for Nucleic Acid Biosensing
This chapter details the use of gold nanorods conjugated with peptide nucleic acid probes for sequence-specific detection of circulating tumor DNA...
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Multi-antigen spherical nucleic acid cancer vaccines
Cancer vaccines must activate multiple immune cell types to be effective against aggressive tumours. Here we report the impact of the structural...
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Nanotechnology-Based Nucleic Acid Vaccines for Treatment of Ovarian Cancer
Anticancer vaccines represent a promising approach for effective treatment of cancer and along with recent advantages of nucleic acid-based vaccines...
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Elucidation of the role of nucleolin as a cell surface receptor for nucleic acid-based adjuvants
Nucleic acid-based adjuvants such as CpG oligonucleotides (CpG ODNs) and poly(I:C) are potential vaccine adjuvants for infectious diseases and...
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Oral Delivery of Nucleic Acid Therapies for Local and Systemic Action
Nucleic acid (NA) therapy has gained importance over the past decade due to its high degree of selectivity and minimal toxic effects over...
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Digital PCR-based evaluation of nucleic acid extraction kit performance for the co-purification of cell-free DNA and RNA
BackgroundBlood plasma, one of the most studied liquid biopsies, contains various molecules that have biomarker potential for cancer detection,...
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Methylated Chromenoquinoline as a Novel Nucleus Fluorescent Probe for Nucleic Acid Imaging
Two chromenoquinoline-based fluorescent probes 1a-b have been synthesized and investigated. Photofading behaviors of compounds 1a-b showed that at...
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Lipid Nanoparticles for Nucleic Acid Delivery to Endothelial Cells
Endothelial cells play critical roles in circulatory homeostasis and are also the gateway to the major organs of the body. Dysfunction, injury, and...
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Structure and Function of Cationic and Ionizable Lipids for Nucleic Acid Delivery
Hereditary genetic diseases, cancer, and infectious diseases are affecting global health and become major health issues, but the treatment...
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Nucleic Acid Quality Assessment is Critical to the Success of the Oncomine Dx Target Test for Lung Cancer
Background and ObjectiveThe Oncomine Dx Target Test (ODxTT) has been used as a companion diagnostic test for lung cancer. Here, we evaluated whether...
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Genetic fusion of CCL11 to antigens enhances antigenicity in nucleic acid vaccines and eradicates tumor mass through optimizing T-cell response
Nucleic acid vaccines have shown promising potency and efficacy for cancer treatment with robust and specific T-cell responses. Improving the...
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CNS Delivery of Nucleic Acid Therapeutics: Beyond the Blood–Brain Barrier and Towards Specific Cellular Targeting
Nucleic acid-based therapeutic molecules including small interfering RNA (siRNA), microRNA(miRNA), antisense oligonucleotides (ASOs), messenger RNA...
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Nucleic acid and protein methylation modification in renal diseases
Although great efforts have been made to elucidate the pathological mechanisms of renal diseases and potential prevention and treatment targets that...
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Comparison of Three Viral Nucleic Acid Preamplification Pipelines for Sewage Viral Metagenomics
Viral metagenomics is a useful tool for detecting multiple human viruses in urban sewage. However, more refined protocols are required for its...
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Ultrasensitive Label-Free Nucleic-Acid Biosensors Based on Bimodal Waveguide Interferometers
The bimodal waveguide (BiMW) biosensor is an innovative common path interferometric sensor based on the evanescent field detection principle. This...
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Pharmacokinetics and Pharmacodynamics of Therapeutic Proteins and Nucleic Acids
The rational use of drugs and the design of effective dosage regimens are facilitated by the appreciation of the central paradigm of clinical...