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Role of Inflammation in Tissue Regeneration and Repair
Inflammation plays critical roles in tissue repair and regeneration. After tissue injury, inflammatory immune cells are recruited to the wound site,...
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A natural product biflavonoid scaffold with anti-tryptase activity
Tryptase is a serine protease that is released from mast cells during allergic responses. Tryptase inhibitors are being explored as treatments for...
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Chloroacetate esterase reaction combined with immunohistochemical characterization of the specific tissue microenvironment of mast cells
This study provides a combined histochemical method for detecting enzyme activity of chloroacetate esterase simultaneously with immunolabeling of the...
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Histamine, mast cell tryptase and post-exercise hypotension in healthy and collapsed marathon runners
PurposeHeat stress exacerbates post-exercise hypotension (PEH) and cardiovascular disturbances from elevated body temperature may contribute to...
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Connective tissue mast cells store and release noradrenaline
Mast cells are present in mucosal and connective tissues throughout the body. They synthesize and release a wide variety of bioactive molecules, such...
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Mouse connective tissue mast cell proteases tryptase and carboxypeptidase A3 play protective roles in itch induced by endothelin-1
BackgroundItch is an unpleasant sensation that can be debilitating, especially if it is chronic and of non-histaminergic origin, as treatment options...
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Effect of Bone Marrow Autotransplantation on the Numerical Population of Tryptase-Positive Mast Cells, Heparin Sulfation Degree, and Histamine Content
We studied the effect of bone marrow autotransplantation on the morphofunctional properties and numerical population of mast cells. The experiments...
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Promoting Angiogenesis Using Immune Cells for Tissue-Engineered Vascular Grafts
Implantable tissue-engineered vascular grafts (TEVGs) usually trigger the host reaction which is inextricably linked with the immune system,...
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Identification and protective role of CD34+ stromal cells/telocytes in experimental autoimmune encephalomyelitis (EAE) mouse spleen
Experimental autoimmune encephalomyelitis (EAE) is a classical animal model of human multiple sclerosis (MS) that is most commonly used to study the...
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Inhibition of mast cell tryptase attenuates neuroinflammation via PAR-2/p38/NFκB pathway following asphyxial cardiac arrest in rats
BackgroundCardiac arrest survivors suffer from neurological dysfunction including cognitive impairment. Cerebral mast cells, the key regulators of...
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A role for mast cells and mast cell tryptase in driving neutrophil recruitment in LPS-induced lung inflammation via protease-activated receptor 2 in mice
ObjectiveThis study aims to investigate the role of protease-activated receptor (PAR) 2 and mast cell (MC) tryptase in LPS-induced lung inflammation...
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Systematic comparisons of various markers for mast cell activation in RBL-2H3 cells
Mast cell activation plays a key role in various allergic diseases and anaphylaxis. Several methods/techniques can be used for detection of mast cell...
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Novel high-yield potato protease inhibitor panels block a wide array of proteases involved in viral infection and crucial tissue damage
AbstractViruses critically rely on various proteases to ensure host cell entry and replication. In response to viral infection, the host will induce...
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ER Stress is Involved in Mast Cells Degranulation via IRE1α/miR-125/Lyn Pathway in an Experimental Intracerebral Hemorrhage Mouse Model
The degranulation of mast cells accounts for the development of neuroinflammation following intracerebral hemorrhage (ICH). Inhibition of IRE1α, a...
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Curcumin inhibits the pruritus in mice through mast cell MrgprB2 receptor
BackgroundCurcumin is a diketone compound extracted from the rhizomes of some plants in the Zingiberaceae and Araceae family. It possesses a variety...
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Association of mast-cell-related conditions with hypermobile syndromes: a review of the literature
Ehlers–Danlos syndrome (EDS) is a group of related connective tissue disorders consisting of 13 subtypes, each with its own unique phenotypic and...
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Identifying potential pathogenesis and immune infiltration in diabetic foot ulcers using bioinformatics and in vitro analyses
BackgroundDiabetic foot ulcers (DFU) are among the fastest-growing diseases worldwide. Recent evidence has emphasized the critical role of microRNA...
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Quercetin and Kaempferol inhibit HMC-1 activation via SOCE/NFATc2 signaling and suppress hippocampal mast cell activation in lipopolysaccharide-induced depressive mice
Objective and designMast cells (MCs), as the fastest immune responders, play a critical role in the progression of neuroinflammation-related...
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Par2-mediated responses in inflammation and regeneration: choosing between repair and damage
The protease activated receptor 2 (Par2) plays a pivotal role in various damage models, influencing injury, proliferation, inflammation, and...
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Tissue factor (coagulation factor III): a potential double-edge molecule to be targeted and re-targeted toward cancer
Tissue factor (TF) is a protein that plays a critical role in blood clotting, but recent research has also shown its involvement in cancer...
