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Aryl hydrocarbon receptor regulates IL-22 receptor expression on thymic epithelial cell and accelerates thymus regeneration
Improving regeneration of damaged thymus is important for reconstituting T-cell immunity. Interleukin-22 (IL-22) was proved to improve thymus...
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ILC Differentiation in the Thymus
The thymus provides a microenvironment conducive to the differentiation of innate lymphoid cells (ILCs), supplying IL-7 as well as Notch ligands....
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Tolerance and Transplantation Immunology
In this chapter, we will first discuss about the impact and mechanisms of immunological tolerance, which is differentiated into central and...
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The role of the thymus in allogeneic bone marrow transplantation and the recovery of the peripheral T-cell compartment
As the thymus represents the primary site of T-cell development, optimal thymic function is of paramount importance for the successful reconstitution...
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Complete fatty degeneration of thymus associates with male sex, obesity and loss of circulating naïve CD8+ T cells in a Swedish middle-aged population
BackgroundFatty degeneration of thymus (or thymus involution) has long been considered a normal ageing process. However, there is emerging evidence...
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Immunology of Transplantation and Malignancy
Successful transplantation requires a multitude of important steps: surgical asepsis, development of surgical techniques of vascular anastomosis,...
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Tolerance and Transplantation Immunology
In this chapter, we will first discuss about the impact and mechanisms of immunological tolerance, which is differentiated into central and...
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Neutrophil diversity and plasticity: Implications for organ transplantation
Neutrophils, as the first defenders against external microbes and stimuli, are highly active and finely regulated innate immune cells. Emerging...
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Therapeutic potential of mitochondrial transplantation in modulating immune responses post-cardiac arrest: a narrative review
BackgroundMitochondrial transplantation (MTx) has emerged as a novel therapeutic strategy, particularly effective in diseases characterized by...
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Thymus and autoimmunity
The thymus prevents autoimmune diseases through mechanisms that operate in the cortex and medulla, comprising positive and negative selection and the...
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Cord Blood Transplantation for Very Early-Onset Inflammatory Bowel Disease Caused by Interleukin-10 Receptor Deficiency
PurposeInterleukin-10 receptor (IL-10R) deficiency can result in life-threatening very early-onset inflammatory bowel disease (VEO-IBD). Umbilical...
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Dynamics of thymus function and T cell receptor repertoire breadth in health and disease
T cell recognition of unknown antigens relies on the tremendous diversity of the T cell receptor (TCR) repertoire; generation of which can only occur...
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The thymus and the science of self
The conventional perception asserts that immunology is the science of ‘discrimination’ between self and non-self. This concept is however no longer...
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PIRCHE-II Risk and Acceptable Mismatch Profile Analysis in Solid Organ Transplantation
To optimize outcomes in solid organ transplantation, the HLA genes are regularly compared and matched between the donor and recipient. However, in...
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Care of Children with DiGeorge Before and After Cultured Thymus Tissue Implantation
BackgroundChildren with complete DiGeorge anomaly (cDGA) have congenital athymia plus a myriad of other challenging clinical conditions. The term...
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Prevalence and Characteristics of Non-tuberculous Mycobacteria (NTM) Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation: a Systematic Review and Meta-analysis
PurposeNon-tuberculous mycobacteria (NTM) infections in hematopoietic stem cell transplantation (HSCT) recipients represent a diagnostic and...
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RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus
Type 2 innate lymphoid cells (ILC2) contribute to immune homeostasis, protective immunity and tissue repair. Here we demonstrate that functional ILC2...
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A very low thymus function identifies patients with substantial increased risk for long-term mortality after kidney transplantation
BackgroundEnd-stage renal disease is associated with premature ageing of the T cell immune system but inter-individual variation is substantial. The...
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