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Crosstalk between Alzheimer’s disease and diabetes: a focus on anti-diabetic drugs
Alzheimer’s disease (AD) and Type 2 diabetes mellitus (T2DM) are two of the most common age-related diseases. There is accumulating evidence of an...
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Genetically proxied antidiabetic drugs targets and stroke risk
BackgroundPrevious studies have assessed the association between antidiabetic drugs and stroke risk, but the results are inconsistent. Mendelian...
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Comparison of the efficacy and safety of hypoglycemic treatments in patients with non-alcoholic fatty liver disease and type-2 diabetes: a systematic review and Bayesian network analysis
PurposeThe association between non-alcoholic fatty liver disease (NAFLD) and metabolic disorders, especially type-2 diabetes (T2DM), has been proven...
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Polycystic Ovary Syndrome (PCOS): Clinical Features, Risk Factors, Biomarkers, Treatment, and Therapeutic Strategies
Among reproductive-age women, the most predominant reproductive-metabolic endocrinopathy is polycystic ovary syndrome (PCOS). It is of unknown...
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Thiazolidinedione use and risk of Parkinson’s disease in patients with type 2 diabetes mellitus
The health burden of Parkinson’s disease (PD) and diabetes increases rapidly in China. However, no population-based study of the association between...
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Targeting Epicardial Fat in Obesity and Diabetes Pharmacotherapy
Epicardial adipose tissue surrounds and infiltrates the heart. Epicardial fat displays unique anatomic, genetic, and biomolecular properties. People...
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Suberosin Alleviates Thiazolidinedione-Induced Cardiomyopathy in Diabetic Rats by Inhibiting Ferroptosis via Modulation of ACSL4-LPCAT3 and PI3K-AKT Signaling Pathways
Thiazolidinediones are useful antidiabetic medications. However, their use is associated with adverse side effects like edema, heart failure and bone...
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An Overview of Hypoglycemic Modern Drugs
Modern hypoglycemic drugs mainly include insulin sensitizers, secretagogues (increase insulin output from the pancreas), which take effect by...
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Patient stratification for determining optimal second-line and third-line therapy for type 2 diabetes: the TriMaster study
Precision medicine aims to treat an individual based on their clinical characteristics. A differential drug response, critical to using these...
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The association of antidiabetic medications and Mini-Mental State Examination scores in patients with diabetes and dementia
BackgroundThe effect of antidiabetic medication on cognitive function is unclear. We analyzed the association between five antidiabetic drugs and...
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Hormones and Hormones Antagonists
Diabetes mellitus (DM) encompasses a group of metabolic disorders characterized by persistent elevation of blood sugar levels. This condition arises...
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Cancer and diabetes: the interlinking metabolic pathways and repurposing actions of antidiabetic drugs
Cancers are regarded as one of the main causes of death and result in high health burden worldwide. The management of cancer include chemotherapy,...
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PPARG activation promotes the proliferation of colorectal cancer cell lines and enhances the antiproliferative effect of 5-fluorouracil
BackgroundPeroxisome proliferator-activated receptor gamma (PPARG) is a member of the nuclear receptor family. It is involved in the regulation of...
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Lectures 9 and 10: Endocrine System & Hormones
The Endocrine System consists the following organs: Hypothalamus, pituitary (anterior & posterior parts), pineal, thyroid, 4 parathyroids, thymus,...
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Assessing the Clinical Correlation between Alzheimer's disease and Type-2 Diabetes Mellitus: Current Strategies and Emerging Perspectives
Purpose of ReviewThis article aims to provide a brief overview of novel therapeutic approaches for combating type 2 diabetes mellitus (T2DM) and...
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Targeting Retinol-Binding Protein 4 (RBP4) in the Management of Cardiometabolic Diseases
The ancient use of herbs for the treatment of various human diseases have been documented, with several scientific literatures supporting the use of...
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Association of semaglutide with risk of suicidal ideation in a real-world cohort
Concerns over reports of suicidal ideation associated with semaglutide treatment, a glucagon-like peptide 1 receptor (GLP1R) agonist medication for...
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Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is a common endocrine–reproductive disorder affecting 8% to 13% of women of reproductive age worldwide. Although the...