Search
Search Results
-
The immunome of mobilized peripheral blood stem cells is predictive of long-term outcomes and therapy-related myeloid neoplasms in patients with multiple myeloma undergoing autologous stem cell transplant
Upfront autologous stem cell transplant (ASCT) is the standard of care for newly diagnosed multiple myeloma (MM) patients. However, relapse is...
-
T-cell priming transcriptomic markers: implications of immunome heterogeneity for precision immunotherapy
Immune checkpoint blockade is effective for only a subset of cancers. Targeting T-cell priming markers (TPMs) may enhance activity, but proper...
-
Vaccines and Immunoinformatics for Vaccine Design
The host immune system recognizes and responds to the selective antigens or epitopes (immunome) of the intruding pathogen over an entire organism....
-
The Advent of Precision Immunology : Immunogenetics at the Center of Immune Cell Analysis in Health and Disease
Adaptive immune cells (i.e., lymphocytes of the B and T lineage) are equipped with unique antigen receptors, which collectively form a highly diverse...
-
Introduction on Cancer Immunodiagnosis
With the increasing burden of cancer, there is a growing need for efficient diagnostic, prognostic and prediction tools to facilitate patient...
-
A graph centrality-based approach for candidate gene prediction for type 1 diabetes
Type 1 diabetes mellitus (T1DM) or insulin-dependent diabetes is an autoimmune disease that may pose life-threatening situations to individuals. In...
-
Multi-proteomic Analysis Revealed Distinct Protein Profiles in Cerebrospinal Fluid of Patients Between Anti-NMDAR Encephalitis NORSE and Cryptogenic NORSE
New-onset refractory status epilepticus (NORSE) is rare but intractable. Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis and cryptogenic...
-
-
Immunogenetics Methods and Protocols
This open access book explores techniques for working in the field of immunogenetics, i.e. fundamental and translational research into the adaptive...
-
Multi-level analysis of the gut–brain axis shows autism spectrum disorder-associated molecular and microbial profiles
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by heterogeneous cognitive, behavioral and communication impairments....
-
Soluble immune checkpoints: implications for cancer prognosis and response to immune checkpoint therapy and conventional therapies
Longitudinal sampling of tumor tissue from patients with solid cancers, aside from melanoma and a few other cases, is often unfeasible, and thus may...
-
-
Protein-based prognostic signature for predicting the survival and immunotherapeutic efficiency of endometrial carcinoma
BackgroundEndometrial cancer (EC) is the most frequent malignancy of the female genital tract worldwide. Our study aimed to construct an effective...
-
Regulatory T cells induce a suppressive immune milieu and promote lymph node metastasis in intrahepatic cholangiocarcinoma
BackgroundEmerging evidence indicates that immunogenicity plays an important role in intrahepatic cholangiocarcinoma (ICC). Herein, we systematically...
-
-
Neoadjuvant atezolizumab for resectable non-small cell lung cancer: an open-label, single-arm phase II trial
In an ongoing, open-label, single-arm phase II study ( NCT02927301 ), 181 patients with untreated, resectable, stage IB–IIIB non-small cell lung...
-
Unveiling the hidden role of disulfidptosis in kidney renal clear cell carcinoma: a prognostic signature for personalized treatment
The role of disulfidptosis in kidney renal clear cell carcinoma (KIRC) remains unknown. This study investigated disulfidptosis-related biomarkers for...
-
High-Resolution and Multidimensional Phenotypes Can Complement Genomics Data to Diagnose Diseases in the Neonatal Population
Advances in genomic medicine have greatly improved our understanding of human diseases. However, phenome is not well understood. High-resolution and...
-
The rise of big data: deep sequencing-driven computational methods are transforming the landscape of synthetic antibody design
Synthetic antibodies (Abs) represent a category of artificial proteins capable of closely emulating the functions of natural Abs. Their in vitro...
-
