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Thalamocortical Circuit Controls Neuropathic Pain via Up-regulation of HCN2 in the Ventral Posterolateral Thalamus
The thalamocortical (TC) circuit is closely associated with pain processing. The hyperpolarization-activated cyclic nucleotide-gated (HCN) 2 channel...
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Aberrant dynamic functional connectivity of thalamocortical circuitry in major depressive disorder
Thalamocortical circuitry has a substantial impact on emotion and cognition. Previous studies have demonstrated alterations in thalamocortical...
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Compensatory thalamocortical functional hyperconnectivity in type 2 Diabetes Mellitus
Type 2 diabetes mellitus (T2DM) is associated with brain damage and cognitive decline. Despite the fact that the thalamus involves aspects of...
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Oligodendrocyte precursor cells engulf synapses during circuit remodeling in mice
Oligodendrocyte precursor cells (OPCs) give rise to myelinating oligodendrocytes throughout life, but the functions of OPCs are not limited to...
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Distinct thalamocortical circuits underlie allodynia induced by tissue injury and by depression-like states
In humans, tissue injury and depression can both cause pain hypersensitivity, but whether this involves distinct circuits remains unknown. Here, we...
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The Cortico-Limbo-Thalamo-Cortical Circuits: An Update to the Original Papez Circuit of the Human Limbic System
The Papez circuit, first proposed by James Papez in 1937, is a circuit believed to control memory and emotions, composed of the cingulate cortex,...
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Spike-spindle coupling during sleep and its mechanism explanation in childhood focal epilepsy
Childhood focal epilepsy (CFE) is a serious neurological disorder characterized by epileptic seizures arising from a focal or multi-focal zone of the...
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Step by step: cells with multiple functions in cortical circuit assembly
It is often thought that the construction of cortical circuits occurs as the result of an elegantly designed process that unfolds sequentially as an...
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Development of reciprocal connections between the dorsal lateral geniculate nucleus and the thalamic reticular nucleus
The thalamic reticular nucleus (TRN) serves as an important node between the thalamus and neocortex, regulating thalamocortical rhythms and sensory...
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The microstructural change of the brain and its clinical severity association in pediatric Tourette syndrome patients
BackgroundGilles de la Tourette syndrome (GTS) is a prevalent pediatric neurological disorder. Most studies point to abnormalities in the...
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Towards real-world generalizability of a circuit for action-stop**
Two decades of cross-species neuroscience research on rapid action-stop** in the laboratory has provided motivation for an underlying...
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Proteostasis failure exacerbates neuronal circuit dysfunction and sleep impairments in Alzheimer’s disease
Failed proteostasis is a well-documented feature of Alzheimer’s disease, particularly, reduced protein degradation and clearance. However, the...
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Untangling the cortico-thalamo-cortical loop: cellular pieces of a knotty circuit puzzle
Functions of the neocortex depend on its bidirectional communication with the thalamus, via cortico-thalamo-cortical (CTC) loops. Recent work...
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The Cerebrocerebellar System
The cerebellum has massive reciprocal interconnections with the cerebral cortex and with cerebral subcortical structures that complement its...
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Adolescent thalamic inhibition leads to long-lasting impairments in prefrontal cortex function
Impaired cortical maturation is a postulated mechanism in the etiology of neurodevelopmental disorders, including schizophrenia. In the sensory...
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The Contribution of the External Globus Pallidus to Basal Ganglia Circuit Oscillatory Activity in an Experimental Model of Parkinson’s Disease
Aberrant synchronous β oscillations in motor neural networks in dopamine (DA) deficiency are associated with motor impairments in Parkinson’s disease...
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Cellular Mechanisms of Thalamocortical Oscillations in the Slee** Brain
Oscillatory activity is an emerging property of the thalamocortical system. The patterns and dominant frequencies of these oscillations depend on the...
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Long-range inhibitory intersection of a retrosplenial thalamocortical circuit by apical tuft-targeting CA1 neurons
Hippocampus, granular retrosplenial cortex (RSCg), and anterior thalamic nuclei (ATN) interact to mediate diverse cognitive functions. To identify...
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The role of astrocyte‐mediated plasticity in neural circuit development and function
Neuronal networks are capable of undergoing rapid structural and functional changes called plasticity, which are essential for sha** circuit...
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SPINDILOMETER: a model describing sleep spindles on EEG signals for polysomnography
This paper aims to present a model called SPINDILOMETER, which we propose to be integrated into polysomnography (PSG) devices for researchers focused...
