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1. Conventional Tregs in treatment-naïve rheumatoid arthritis are deficient in suppressive function with an increase in percentage of CXCR3 and CCR6 expressing Tregs

   In rheumatoid arthritis (RA), immune homeostasis is maintained by T regulatory cells (Tregs) that in an inflammatory milieu can change towards...

   Vallayyachari Kommoju, Christina Mary Mariaselvam, ... Vir Singh Negi in Immunologic Research

   Article 27 December 2023
   

2. MicroRNA-125a-5p regulates the effect of Tregs on Th1 and Th17 through targeting ETS-1/STAT3 in psoriasis

   Background

   Psoriasis is an inflammatory disease mediated by helper T (Th)17 and Th1 cells. MicroRNA-125a (miR-125a) is reduced in the lesional skin of...

   Kexiang Yan, Fuxin Zhang, ... Ling Han in Journal of Translational Medicine

   Article Open access 29 September 2023
   

3. Localization and movement of Tregs in gastrointestinal tract: a systematic review

   Background

   The intestine is rich in food-derived and microbe-derived antigens. Regulatory T cells (Tregs) are an essential T-cell population that...

   Yosuke Harada, Kentaro Miyamoto, ... Tomohisa Su**o in Inflammation and Regeneration

   Article Open access 03 November 2022
   

4. Dexmedetomidine alleviates acute lung injury by promoting Tregs differentiation via activation of AMPK/SIRT1 pathway

   Objectives

   To explore the anti-inflammatory effect and the potential mechanism of dexmedetomidine in ARDS/ALI.

   Materials and Methods

   C57BL/6 mice and...

   Zheng-tao Zhang, Ke **e, ... Fang Xu in Inflammopharmacology

   Article 19 December 2022
   

5. Tregs in Autoimmune Uveitis

   Uveitis is a chronic disease with relapsing and remitting ocular attack, which requires corticosteroids and systemic immunosuppression to prevent...

   Zhaohao Huang, Wenli Li, Wenru Su in T Regulatory Cells in Human Health and Diseases

   Chapter 2021
   

6. EVs vs. EVs: MSCs and Tregs as a source of invisible possibilities

   Extracellular vesicles (EVs) are produced by various cells and exist in most biological fluids. They play an important role in cell–cell signaling,...

   Zahra Heydari, Maria Peshkova, ... Peter Timashev in Journal of Molecular Medicine

   Article 17 December 2022
   

7. Small extracellular vesicles derived from PD-L1-modified mesenchymal stem cell promote Tregs differentiation and prolong allograft survival

   We aimed to explore whether programmed cell death protein-1 ligand (PD-L1) modification on small extracellular vesicles (sEVs) could promote T...

   Qifeng Ou, **aolin Dou, ... Ding Pan in Cell and Tissue Research

   Article 11 June 2022
   

8. Targeting Inhibitory Cells Such as Tregs and MDSCs in the Tuberculous Granuloma

   Mycobacterium tuberculosis (Mtb) is one of the most successful pathogenic agents infecting more than one-quarter of the human population and causing...

   Sadiya Parveen, John R. Murphy, William R. Bishai in Advances in Host-Directed Therapies Against Tuberculosis

   Chapter 2021
   

9. Potential anti-tumor effects of regulatory T cells in the tumor microenvironment: a review

   Regulatory T cells (Tregs) expressing the transcription factor FoxP3 are essential for maintaining immunological balance and are a significant...

   Yu Li, Cangang Zhang, ... Peng Luo in Journal of Translational Medicine

   Article Open access 20 March 2024
   

10. Treg plasticity and human diseases

    Introduction

    As a subset of CD4 ⁺ T cells, regulatory T cells (Tregs) with the characteristic expression of transcription factor FOXP3 play a key role...

    Zheng Zhang, Jihua Guo, Rong Jia in Inflammation Research

    Article 25 October 2023
    

11. Diosmin nanocrystal gel alleviates imiquimod-induced psoriasis in rats via modulating TLR7,8/NF-κB/micro RNA-31, AKT/mTOR/P70S6K milieu, and Tregs/Th17 balance

    Abstract

    Diosmin is a flavonoid with promising anti-inflammatory and antioxidant properties. However, it has difficult physicochemical characteristics...

    Yasmine Shahine, Sarah A. Abd El-Aal, ... Sherihan Salaheldin Abdelhamid Ibrahim in Inflammopharmacology

    Article Open access 03 April 2023
    

12. Blockade of CCR4 breaks immune tolerance in chronic hepatitis B patients by modulating regulatory pathways

    Background

    Immunotargets including checkpoint inhibitors and toll-like receptor 8 agonists have recently gained attention for the recovery of...

    Arshi Khanam, Alip Ghosh, ... Shyam Kottilil in Journal of Translational Medicine

    Article Open access 21 April 2023
    

13. The role of regulatory T cells in vitiligo and therapeutic advances: a mini-review

    Background

    Regulatory T cells (Tregs) play vital roles in controlling immune reactions and maintaining immune tolerance in the body. The targeted...

    Shiyu **, Sheng Wan, ... Cui** Guan in Inflammation Research

    Article 05 June 2024
    

14. Targeting CXCR4 impaired T regulatory function through PTEN in renal cancer patients

    Background

    Tregs trafficking is controlled by CXCR4. In Renal Cell Carcinoma (RCC), the effect of the new CXCR4 antagonist, R54, was explored in...

    Sara Santagata, Giuseppina Rea, ... Stefania Scala in British Journal of Cancer

    Article Open access 04 May 2024
    

15. Targeting ACC1 in T cells ameliorates psoriatic skin inflammation

    Abstract

    Psoriasis is a chronic inflammatory skin disease driven by the IL-23/IL-17 axis. It results from excessive activation of effector T cells,...

    Yu-San Kao, Panagiota Mamareli, ... Tim Sparwasser in Journal of Molecular Medicine

    Article Open access 18 August 2023
    

16. IRF4 overexpression promotes the transdifferentiation of tregs into macrophage‐like cells to inhibit the development of colon cancer

    Background

    Interferon regulatory factor 4 (IRF4) is a transcription factor from the IRF factor family that exerts regulatory functions in the immune...

    Jiwei Wang, Song Li, ... Bin Lai in Cancer Cell International

    Article Open access 19 January 2021
    

17. Exploring CCR5 + T regulatory cell subset dysfunction in type 1 diabetes patients: implications for immune regulation

    T regulatory lymphocytes (Treg) expressing CCR5 exhibit strong suppression activity in various autoimmune disorders. However, there remains a lack of...

    Ławrynowicz Urszula, Juhas Ulana, ... Ryba-Stanisławowska Monika in Immunologic Research

    Article Open access 27 June 2024
    

18. Bronchoalveolar Tregs are associated with duration of mechanical ventilation in acute respiratory distress syndrome

    Background

    Foxp3 ⁺ regulatory T cells (Tregs) play essential roles in immune homeostasis and repair of damaged lung tissue. We hypothesized that...

    Dustin L. Norton, Agathe Ceppe, ... Jason R. Mock in Journal of Translational Medicine

    Article Open access 11 November 2020
    

19. Gut microbiota regulation of T lymphocyte subsets during systemic lupus erythematosus

    Background

    Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by disturbance of pro-inflammatory and anti-inflammatory...

    Fen-** Lian, Fen Zhang, ... Jun-Wei Chen in BMC Immunology

    Article Open access 08 July 2024
    

20. Amyloid-β specific regulatory T cells attenuate Alzheimer’s disease pathobiology in APP/PS1 mice

    Background

    Regulatory T cells (Tregs) maintain immune tolerance. While Treg-mediated neuroprotective activities are now well-accepted, the lack of...

    Pravin Yeapuri, Jatin Machhi, ... Howard E. Gendelman in Molecular Neurodegeneration

    Article Open access 18 December 2023