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Genome-scale CRISPR screen reveals neddylation to contribute to cisplatin resistance of testicular germ cell tumours
BackgroundType II testicular germ cell tumours (TGCT) are the most prevalent tumours in young men. Patients suffering from cisplatin-resistant TGCTs...
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Advancing clinical and translational research in germ cell tumours (GCT): recommendations from the Malignant Germ Cell International Consortium
Germ cell tumours (GCTs) are a heterogeneous group of rare neoplasms that present in different anatomical sites and across a wide spectrum of patient...
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Novel sequential therapy with metformin enhances the effects of cisplatin in testicular germ cell tumours via YAP1 signalling
BackgroundTesticular germ cell tumours (TGCTs) are the most commonly diagnosed malignancy in young men. Although cisplatin has been shown to be...
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Predicted leukocyte telomere length and risk of germ cell tumours
BackgroundGenetically predicted leukocyte telomere length (LTL) has been evaluated in several studies of childhood and adult cancer. We test whether...
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Targeting oncogenic microRNAs from the miR-371~373 and miR-302/367 clusters in malignant germ cell tumours causes growth inhibition through cell cycle disruption
BackgroundMiR-371~373 and miR-302/367 cluster over-expression occurs in all malignant germ cell tumours (GCTs), regardless of age (paediatric/adult),...
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Transcriptome analysis reveals upregulation of immune response pathways at the invasive tumour front of metastatic seminoma germ cell tumours
BackgroundTesticular germ cell tumours (TGCTs) have a high metastasis rate. However, the mechanisms related to their invasion, progression and...
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Detection of recurrences using serum miR-371a-3p during active surveillance in men with stage I testicular germ cell tumours
BackgroundMiR-371a-3p predicts the presence of a macroscopic non-teratomatous germ cell tumour (GCT). We hypothesised that miR-371a-3p can also...
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Combination treatment of zinc and selenium intervention ameliorated BPA-exposed germ cell damage in SD rats: elucidation of molecular mechanisms
Bisphenol A (BPA) is a commonly used environmental toxicant, is easily exposed to the human body and causes testicular damage, sperm abnormalities,...
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Risk and mortality of testicular cancer in patients with neurodevelopmental or other psychiatric disorders
BackgroundBoth testicular germ cell tumours (TGCT) and neurodevelopmental disorders are associated with urogenital malformations. Few studies have...
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RANKL regulates testicular cancer growth and Denosumab treatment has suppressive effects on GCNIS and advanced seminoma
BackgroundTesticular germ cell tumours (TGCTs) have a high sensitivity to chemotherapy and a high cure rate, although with serious adverse effects....
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Influence of Nodal signalling on pluripotency factor expression, tumour cell proliferation and cisplatin-sensitivity in testicular germ cell tumours
BackgroundTesticular germ cell tumours (TGCTs) are characterised by an overall high cisplatin-sensitivity which has been linked to their continued...
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Whole-genome methylation analysis of testicular germ cells from cryptozoospermic men points to recurrent and functionally relevant DNA methylation changes
BackgroundSeveral studies have reported an association between male infertility and aberrant sperm DNA methylation patterns, in particular in...
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Impact of a one-year supervised physical activity program on long-term cancer-related fatigue and mediating effects of the gut microbiota in metastatic testicular cancer patients: protocol of the prospective multicentre, randomized controlled phase-III STARTER trial
BackgroundTesticular germ cell tumours (TGCTs) are the most common malignancy in men aged 15–40 years, with increasing incidence worldwide. About...
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The impact of a supranetwork multidisciplinary team (SMDT) on decision-making in testicular cancers: a 10-year overview of the Anglian Germ Cell Cancer Collaborative Group (AGCCCG)
BackgroundThe germ cell supranetwork multidisciplinary team (SMDT) for the Anglian Network covers a population of 7.5 million.
Methods ...
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Outcomes of relapsed clinical stage I versus de novo metastatic testicular cancer patients: an analysis of the IGCCCG Update database
BackgroundActive surveillance after orchiectomy is the preferred management in clinical stage I (CSI) germ-cell tumours (GCT) associated with a 15 to...
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Somatic hits in mismatch repair genes in colorectal cancer among non-seminoma testicular cancer survivors
BackgroundNon-seminoma testicular cancer survivors (TCS) have an increased risk of develo** colorectal cancer (CRC) when they have been treated...
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Human germ cell tumours from a developmental perspective
Human germ cell tumours (GCTs) are derived from stem cells of the early embryo and the germ line. They occur in the gonads (ovaries and testes) and...
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Increased levels of XPA might be the basis of cisplatin resistance in germ cell tumours
BackgroundGerm cell tumours (GCTs) represent a highly curable malignity as they respond well to cisplatin (CDDP)-based chemotherapy. Nevertheless, a...
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CDK4/6 inhibition presents as a therapeutic option for paediatric and adult germ cell tumours and induces cell cycle arrest and apoptosis via canonical and non-canonical mechanisms
BackgroundGerm cell tumours (GCTs) are the most common solid malignancies in young men. Although high cure rates can be achieved, metastases,...
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A pancancer analysis of the carcinogenic role of receptor-interacting serine/threonine protein kinase-2 (RIPK2) in human tumours
BackgroundTo explore the expression and carcinogenic mechanism of RIPK2 in human tumours, and to provide the theoretical basis for the further study...
