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Structural Changes in the Brain in Patients with Temporal Lobe Epilepsy and Comorbid Depression
Objectives . To assess the morphological features of brain structures in patients with temporal lobe epilepsy and comorbid depression. Materials and...
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Similarities and differences of dynamic and static spontaneous brain activity between left and right temporal lobe epilepsy
To comprehensively investigate the potential temporal dynamic and static abnormalities of spontaneous brain activity (SBA) in left temporal lobe...
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The high frequency oscillations in the amygdala, hippocampus, and temporal cortex during mesial temporal lobe epilepsy
The mesial temporal lobe epilepsy (MTLE) seizures are believed to originate from medial temporal structures, including the amygdala, hippocampus, and...
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Visualization of the Spatiotemporal Propagation of Interictal Spikes in Temporal Lobe Epilepsy: A MEG Pilot Study
Magnetoencephalography (MEG) is clinically used to localize interictal spikes in discrete brain areas of epilepsy patients through the equivalent...
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Relationship between visuoperceptual functions and parietal structural abnormalities in temporal lobe epilepsy
Progressive gray matter volume reductions beyond the epileptogenic area has been described in temporal lobe epilepsy. There is less evidence...
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High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy
The pathophysiology of epilepsy underlies a complex network dysfunction between neurons and glia, the molecular cell type-specific contributions of...
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Clinical characteristics of MRI-negative temporal lobe epilepsy
PurposeTo investigate the characteristics of patients with MRI-negative temporal lobe epilepsy (TLE) (1.5 T brain MRI) in comparison with: (i)...
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Differential Expression of the β3 Subunit of Voltage-Gated Ca2+ Channel in Mesial Temporal Lobe Epilepsy
The purpose of this study was to identify and validate new putative lead drug targets in drug-resistant mesial temporal lobe epilepsy (mTLE) starting...
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Brain single cell transcriptomic profiles in episodic memory phenotypes associated with temporal lobe epilepsy
Memory dysfunction is prevalent in temporal lobe epilepsy (TLE), but little is known about the underlying molecular etiologies. Single-nucleus RNA...
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Levetiracetam Modulates EEG Microstates in Temporal Lobe Epilepsy
To determine the effects of Levetiracetam (LEV) therapy using EEG microstates analysis in a population of newly diagnosed Temporal Lobe Epilepsy...
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Hyperphosphorylated Tau in Mesial Temporal Lobe Epilepsy: a Neuropathological and Cognitive Study
Temporal lobe epilepsy (TLE) often courses with cognitive deficits, but its underlying neuronal basis remains unclear. Confluent data suggest that...
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Clinical Features of Temporal Epilepsy with Involvement of the Insular Lobe
Objectives. To identify the clinical features of the course of temporal epilepsy with involvement of the insular cortex in the epileptic process. Mater...
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Low-frequency Stimulation at the Subiculum Prevents Extensive Secondary Epileptogenesis in Temporal Lobe Epilepsy
Secondary epileptogenesis is characterized by increased epileptic susceptibility and a tendency to generate epileptiform activities outside the...
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Anticonvulsant Effects of Royal Jelly in Kainic Acid-Induced Animal Model of Temporal Lobe Epilepsy Through Antioxidant Activity
Temporal lobe epilepsy (TLE) is the most common form of partial and drug-resistant epilepsy, characterized by recurrent seizures originating from...
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Identification of TIMP1 as an inflammatory biomarker associated with temporal lobe epilepsy based on integrated bioinformatics and experimental analyses
BackgroundEpilepsy is the second most prevalent neurological disease. Although there are many antiseizure drugs, approximately 30% of cases are...
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A Ketogenic Diet may Improve Cognitive Function in Rats with Temporal Lobe Epilepsy by Regulating Endoplasmic Reticulum Stress and Synaptic Plasticity
A ketogenic diet (KD) is often used in the treatment of refractory epilepsy. Many studies have found that it also has a positive impact on cognitive...
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Investigating the mechanism of antiepileptogenic effect of apigenin in kainate temporal lobe epilepsy: possible role of mTOR
Clarifying the underlying mechanisms of epileptogenesis is important in preventing the progression of chronic epilepsy. In epilepsy, the mTOR...
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Brain structural connectivity sub ty** in unilateral temporal lobe epilepsy
To categorize and clinically characterize subtypes of brain structural connectivity patterns in unilateral temporal lobe epilepsy (TLE). Voxel based...
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Astrocyte-derived SerpinA3N promotes neuroinflammation and epileptic seizures by activating the NF-κB signaling pathway in mice with temporal lobe epilepsy
Impaired activation and regulation of the extinction of inflammatory cells and molecules in injured neuronal tissues are key factors in the...
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Distinguishing Patients with MRI-Negative Temporal Lobe Epilepsy from Normal Controls Based on Individual Morphological Brain Network
Temporal Lobe Epilepsy (TLE) is the most common subtype of focal epilepsy and the most refractory to drug treatment. Roughly 30% of patients do not...
